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The Breast Cancer to Bone (B2B) Metastases Research Program: a multi-disciplinary investigation of bone metastases from breast cancer.

Brockton NT, Gill SJ, Laborge SL, Paterson AH, Cook LS, Vogel HJ, Shemanko CS, Hanley DA, Magliocco AM, Friedenreich CM - BMC Cancer (2015)

Bottom Line: Despite decades of informative research, the effective prevention, prediction and treatment of these lesions remains elusive.These include the impact of lifestyle factors and inflammation on risk of bone metastases, the gene expression features of the primary tumour, the potential role for metabolomics in early detection of bone metastatic disease and the signalling pathways that drive the metastatic lesions in the bone.Recurrences are identified through medical chart abstractions.

View Article: PubMed Central - PubMed

Affiliation: Department of Cancer Epidemiology and Prevention Research, CancerControl Alberta, Alberta Health Services, Room 515C, Holy Cross Centre, 2210 2nd St, SW, Calgary, AB, T2S 3C3, Canada. nigel.brockton@albertahealthservices.ca.

ABSTRACT

Background: Bone is the most common site of breast cancer distant metastasis, affecting 50-70 % of patients who develop metastatic disease. Despite decades of informative research, the effective prevention, prediction and treatment of these lesions remains elusive. The Breast Cancer to Bone (B2B) Metastases Research Program consists of a prospective cohort of incident breast cancer patients and four sub-projects that are investigating priority areas in breast cancer bone metastases. These include the impact of lifestyle factors and inflammation on risk of bone metastases, the gene expression features of the primary tumour, the potential role for metabolomics in early detection of bone metastatic disease and the signalling pathways that drive the metastatic lesions in the bone.

Methods/design: The B2B Research Program is enrolling a prospective cohort of 600 newly diagnosed, incident, stage I-IIIc breast cancer survivors in Alberta, Canada over a five year period. At baseline, pre-treatment/surgery blood samples are collected and detailed epidemiologic data is collected by in-person interview and self-administered questionnaires. Additional self-administered questionnaires and blood samples are completed at specified follow-up intervals (24, 48 and 72 months). Vital status is obtained prior to each follow-up through record linkages with the Alberta Cancer Registry. Recurrences are identified through medical chart abstractions. Each of the four projects applies specific methods and analyses to assess the impact of serum vitamin D and cytokine concentrations, tumour transcript and protein expression, serum metabolomic profiles and in vitro cell signalling on breast cancer bone metastases.

Discussion: The B2B Research Program will address key issues in breast cancer bone metastases including the association between lifestyle factors (particularly a comprehensive assessment of vitamin D status) inflammation and bone metastases, the significance or primary tumour gene expression in tissue tropism, the potential of metabolomic profiles for risk assessment and early detection and the signalling pathways controlling the metastatic tumour microenvironment. There is substantial synergy between the four projects and it is hoped that this integrated program of research will advance our understanding of key aspects of bone metastases from breast cancer to improve the prevention, prediction, detection, and treatment of these lesions.

No MeSH data available.


Related in: MedlinePlus

B2B Research Program timeline. Recruitment for the B2B Cohort began in 2010, and steadily increased through successive operational enhancements, key partnerships, and implementation of a centralized biospecimen ascertainment infrastructure
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Fig2: B2B Research Program timeline. Recruitment for the B2B Cohort began in 2010, and steadily increased through successive operational enhancements, key partnerships, and implementation of a centralized biospecimen ascertainment infrastructure

Mentions: The population-based ascertainment of breast cancer patients for the B2B Research Program was developed in partnership with the Alberta Cancer Research Biobank (ACRB) and the Alberta Cancer Registry (ACR). The ACR is a province-wide cancer registry that has been awarded a Gold Certification from the North American Association of Central Cancer Registries since 1999, indicating the highest quality of completeness, accuracy, and timeliness of cancer reporting. Prior to the establishment of the B2B Research Program, the ACRB focused predominantly on the collection of fresh-frozen tumour tissue from breast cancer patients in addition to a limited collection of largely post-surgical blood samples. The need to recruit a population-based cohort and collect pre-surgical blood samples, led to the development of the Comprehensive Biospecimen Rapid Ascertainment (CoBRA) system (Fig. 2). The CoBRA system is responsible for the ascertainment of patients and their recruitment into the ACRB. The ACRB is approved by both the institutional and provincial research ethics boards (HREBA and CHREB, respectively).Fig. 2


The Breast Cancer to Bone (B2B) Metastases Research Program: a multi-disciplinary investigation of bone metastases from breast cancer.

Brockton NT, Gill SJ, Laborge SL, Paterson AH, Cook LS, Vogel HJ, Shemanko CS, Hanley DA, Magliocco AM, Friedenreich CM - BMC Cancer (2015)

B2B Research Program timeline. Recruitment for the B2B Cohort began in 2010, and steadily increased through successive operational enhancements, key partnerships, and implementation of a centralized biospecimen ascertainment infrastructure
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4496930&req=5

Fig2: B2B Research Program timeline. Recruitment for the B2B Cohort began in 2010, and steadily increased through successive operational enhancements, key partnerships, and implementation of a centralized biospecimen ascertainment infrastructure
Mentions: The population-based ascertainment of breast cancer patients for the B2B Research Program was developed in partnership with the Alberta Cancer Research Biobank (ACRB) and the Alberta Cancer Registry (ACR). The ACR is a province-wide cancer registry that has been awarded a Gold Certification from the North American Association of Central Cancer Registries since 1999, indicating the highest quality of completeness, accuracy, and timeliness of cancer reporting. Prior to the establishment of the B2B Research Program, the ACRB focused predominantly on the collection of fresh-frozen tumour tissue from breast cancer patients in addition to a limited collection of largely post-surgical blood samples. The need to recruit a population-based cohort and collect pre-surgical blood samples, led to the development of the Comprehensive Biospecimen Rapid Ascertainment (CoBRA) system (Fig. 2). The CoBRA system is responsible for the ascertainment of patients and their recruitment into the ACRB. The ACRB is approved by both the institutional and provincial research ethics boards (HREBA and CHREB, respectively).Fig. 2

Bottom Line: Despite decades of informative research, the effective prevention, prediction and treatment of these lesions remains elusive.These include the impact of lifestyle factors and inflammation on risk of bone metastases, the gene expression features of the primary tumour, the potential role for metabolomics in early detection of bone metastatic disease and the signalling pathways that drive the metastatic lesions in the bone.Recurrences are identified through medical chart abstractions.

View Article: PubMed Central - PubMed

Affiliation: Department of Cancer Epidemiology and Prevention Research, CancerControl Alberta, Alberta Health Services, Room 515C, Holy Cross Centre, 2210 2nd St, SW, Calgary, AB, T2S 3C3, Canada. nigel.brockton@albertahealthservices.ca.

ABSTRACT

Background: Bone is the most common site of breast cancer distant metastasis, affecting 50-70 % of patients who develop metastatic disease. Despite decades of informative research, the effective prevention, prediction and treatment of these lesions remains elusive. The Breast Cancer to Bone (B2B) Metastases Research Program consists of a prospective cohort of incident breast cancer patients and four sub-projects that are investigating priority areas in breast cancer bone metastases. These include the impact of lifestyle factors and inflammation on risk of bone metastases, the gene expression features of the primary tumour, the potential role for metabolomics in early detection of bone metastatic disease and the signalling pathways that drive the metastatic lesions in the bone.

Methods/design: The B2B Research Program is enrolling a prospective cohort of 600 newly diagnosed, incident, stage I-IIIc breast cancer survivors in Alberta, Canada over a five year period. At baseline, pre-treatment/surgery blood samples are collected and detailed epidemiologic data is collected by in-person interview and self-administered questionnaires. Additional self-administered questionnaires and blood samples are completed at specified follow-up intervals (24, 48 and 72 months). Vital status is obtained prior to each follow-up through record linkages with the Alberta Cancer Registry. Recurrences are identified through medical chart abstractions. Each of the four projects applies specific methods and analyses to assess the impact of serum vitamin D and cytokine concentrations, tumour transcript and protein expression, serum metabolomic profiles and in vitro cell signalling on breast cancer bone metastases.

Discussion: The B2B Research Program will address key issues in breast cancer bone metastases including the association between lifestyle factors (particularly a comprehensive assessment of vitamin D status) inflammation and bone metastases, the significance or primary tumour gene expression in tissue tropism, the potential of metabolomic profiles for risk assessment and early detection and the signalling pathways controlling the metastatic tumour microenvironment. There is substantial synergy between the four projects and it is hoped that this integrated program of research will advance our understanding of key aspects of bone metastases from breast cancer to improve the prevention, prediction, detection, and treatment of these lesions.

No MeSH data available.


Related in: MedlinePlus