Limits...
Relevance of Colonic Gas Analysis and Transit Study in Patients With Chronic Constipation.

Park SY, Park HB, Lee JM, Lee HJ, Park CH, Kim HS, Choi SK, Rew JS - J Neurogastroenterol Motil (2015)

Bottom Line: There was no significant correlation between CTT and colon GVS.The median total colon GVS was significantly higher in patients with "CTT ≥ 45 hours" than in those with "CTT < 45 hours" (5.65% vs 4.15%, P = 0.010).There were no significant differences in colon GVS between the functional constipation and IBS-C.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.

ABSTRACT

Background/aims: Colon transit time (CTT) is a useful diagnostic tool in chronic constipation, but requires good patient compliance. We analyzed the correlation between the gas volume score (GVS) and CTT in patients with chronic constipation.

Methods: The study included 145 consecutive patients (65 men) with chronic constipation. The primary outcome was the correlation be-tween the colon GVS and CTT. Secondary outcomes were the differences in colon GVS according to CTT and subtypes of chronic constipation.

Results: There were 81 patients with "CTT < 45 hours" and 64 patients with "CTT ≥ 45 hours." In addition, 88 patients were classi-fied as having functional constipation and 57 were classified as having constipation predominant irritable bowel syndrome (IBS-C). There was no significant correlation between CTT and colon GVS. However, the right colon GVS showed a positive cor-relation with right CTT (r = 0.255, P = 0.007). The median total colon GVS was significantly higher in patients with "CTT ≥ 45 hours" than in those with "CTT < 45 hours" (5.65% vs 4.15%, P = 0.010). There were no significant differences in colon GVS between the functional constipation and IBS-C.

Conclusions: We were unable to detect a correlation between GVS and CTT in patients with chronic constipation. However, total colon GVS may be a method of predicting slow transit in patients with chronic constipation.

No MeSH data available.


Related in: MedlinePlus

Colon gas volume score (GVS) according to colon transit. The median total colon GVS was higher in patients with “CTT ≥ 45 hours” than in those with “CTT < 45 hours” (5.66% vs 4.15%, P = 0.010).
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4496912&req=5

f2-jnm-21-433: Colon gas volume score (GVS) according to colon transit. The median total colon GVS was higher in patients with “CTT ≥ 45 hours” than in those with “CTT < 45 hours” (5.66% vs 4.15%, P = 0.010).

Mentions: The Median CTT was 22.8 hours (6.6–32.4 hours) in patients with “CTT < 45 hours” and 73.8 hours (56.7–93.3 hours) in patients with “CTT ≥ 45 hours.” The median total colon GVS was significantly higher in patients with “CTT ≥ 45 hours” than in those with “CTT < 45 hours” (5.66% vs 4.15%, P = 0.010; Fig. 2). There was no difference in RCS between the 2 groups (P > 0.05). However, there were significant difference in LCS and RSCS (Table 2). The ROC curve analysis showed a fair result for the total colon GVS predicting slow transit in patients with chronic constipation. The ROC analysis, the optimal cut-off value to diagnosis slow CTT (over 45 hours) was 4.63% (sensitivity 66.7%, specificity 54.5%, and AUC 0.628 [95% confidence interval, 0.535 and 0.721]; Fig. 3).


Relevance of Colonic Gas Analysis and Transit Study in Patients With Chronic Constipation.

Park SY, Park HB, Lee JM, Lee HJ, Park CH, Kim HS, Choi SK, Rew JS - J Neurogastroenterol Motil (2015)

Colon gas volume score (GVS) according to colon transit. The median total colon GVS was higher in patients with “CTT ≥ 45 hours” than in those with “CTT < 45 hours” (5.66% vs 4.15%, P = 0.010).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4496912&req=5

f2-jnm-21-433: Colon gas volume score (GVS) according to colon transit. The median total colon GVS was higher in patients with “CTT ≥ 45 hours” than in those with “CTT < 45 hours” (5.66% vs 4.15%, P = 0.010).
Mentions: The Median CTT was 22.8 hours (6.6–32.4 hours) in patients with “CTT < 45 hours” and 73.8 hours (56.7–93.3 hours) in patients with “CTT ≥ 45 hours.” The median total colon GVS was significantly higher in patients with “CTT ≥ 45 hours” than in those with “CTT < 45 hours” (5.66% vs 4.15%, P = 0.010; Fig. 2). There was no difference in RCS between the 2 groups (P > 0.05). However, there were significant difference in LCS and RSCS (Table 2). The ROC curve analysis showed a fair result for the total colon GVS predicting slow transit in patients with chronic constipation. The ROC analysis, the optimal cut-off value to diagnosis slow CTT (over 45 hours) was 4.63% (sensitivity 66.7%, specificity 54.5%, and AUC 0.628 [95% confidence interval, 0.535 and 0.721]; Fig. 3).

Bottom Line: There was no significant correlation between CTT and colon GVS.The median total colon GVS was significantly higher in patients with "CTT ≥ 45 hours" than in those with "CTT < 45 hours" (5.65% vs 4.15%, P = 0.010).There were no significant differences in colon GVS between the functional constipation and IBS-C.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.

ABSTRACT

Background/aims: Colon transit time (CTT) is a useful diagnostic tool in chronic constipation, but requires good patient compliance. We analyzed the correlation between the gas volume score (GVS) and CTT in patients with chronic constipation.

Methods: The study included 145 consecutive patients (65 men) with chronic constipation. The primary outcome was the correlation be-tween the colon GVS and CTT. Secondary outcomes were the differences in colon GVS according to CTT and subtypes of chronic constipation.

Results: There were 81 patients with "CTT < 45 hours" and 64 patients with "CTT ≥ 45 hours." In addition, 88 patients were classi-fied as having functional constipation and 57 were classified as having constipation predominant irritable bowel syndrome (IBS-C). There was no significant correlation between CTT and colon GVS. However, the right colon GVS showed a positive cor-relation with right CTT (r = 0.255, P = 0.007). The median total colon GVS was significantly higher in patients with "CTT ≥ 45 hours" than in those with "CTT < 45 hours" (5.65% vs 4.15%, P = 0.010). There were no significant differences in colon GVS between the functional constipation and IBS-C.

Conclusions: We were unable to detect a correlation between GVS and CTT in patients with chronic constipation. However, total colon GVS may be a method of predicting slow transit in patients with chronic constipation.

No MeSH data available.


Related in: MedlinePlus