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Regional Gastrointestinal Transit Times in Patients With Carcinoid Diarrhea: Assessment With the Novel 3D-Transit System.

Gregersen T, Haase AM, Schlageter V, Gronbaek H, Krogh K - J Neurogastroenterol Motil (2015)

Bottom Line: Median colorectal transit time was 5.2 (range: 2.9-40.1) hours in patients versus 18.1 (range: 5.0-134.0) hours in healthy subjects (P = 0.012).Median frequency of pansegmental co-lonic movements was 0.45 (range: 0.03-1.02) per hour in patients and 0.07 (range: 0-0.61) per hour in healthy subjects (P = 0.045).The latter is caused by an increased frequency of pansegmental colonic movements.

View Article: PubMed Central - PubMed

Affiliation: Neurogastroenterology Unit, Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark.

ABSTRACT

Background/aims: The paucity of knowledge regarding gastrointestinal motility in patients with neuroendocrine tumors and carcinoid diarrhea re-stricts targeted treatment. 3D-Transit is a novel, minimally invasive, ambulatory method for description of gastrointestinal motility. The system has not yet been evaluated in any group of patients. We aimed to test the performance of 3D-Transit in patients with carcinoid diarrhea and to compare the patients' regional gastrointestinal transit times (GITT) and colonic motility patterns with those of healthy subjects.

Methods: Fifteen healthy volunteers and seven patients with neuroendocrine tumor and at least 3 bowel movements per day were inves-tigated with 3D-Transit and standard radiopaque markers.

Results: Total GITT assessed with 3D-Transit and radiopaque markers were well correlated (Spearman's rho = 0.64, P = 0.002). Median total GITT was 12.5 (range: 8.5-47.2) hours in patients versus 25.1 (range: 13.1-142.3) hours in healthy (P = 0.007). There was no difference in gastric emptying (P = 0.778). Median small intestinal transit time was 3.8 (range: 1.4-5.5) hours in patients versus 4.4 (range: 1.8-7.2) hours in healthy subjects (P = 0.044). Median colorectal transit time was 5.2 (range: 2.9-40.1) hours in patients versus 18.1 (range: 5.0-134.0) hours in healthy subjects (P = 0.012). Median frequency of pansegmental co-lonic movements was 0.45 (range: 0.03-1.02) per hour in patients and 0.07 (range: 0-0.61) per hour in healthy subjects (P = 0.045).

Conclusions: Three-dimensional Transit allows assessment of regional GITT in patients with diarrhea. Patients with carcinoid diarrhea have faster than normal gastrointestinal transit due to faster small intestinal and colorectal transit times. The latter is caused by an increased frequency of pansegmental colonic movements.

No MeSH data available.


Related in: MedlinePlus

Trajectory of the colonic passage in a healthy subject. The 2 lines illustrate pansegmental colonic movements. The first covers the ascending colon in 22 seconds and the second covers the mid transverse colon, the descending colon and the rectosigmoid colon in 65 seconds. The dots between the 2 pansegmental movements represent slow progression through the hepatic flexure and proximal part of the transverse colon, one dot per 5 minutes.
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f6-jnm-21-423: Trajectory of the colonic passage in a healthy subject. The 2 lines illustrate pansegmental colonic movements. The first covers the ascending colon in 22 seconds and the second covers the mid transverse colon, the descending colon and the rectosigmoid colon in 65 seconds. The dots between the 2 pansegmental movements represent slow progression through the hepatic flexure and proximal part of the transverse colon, one dot per 5 minutes.

Mentions: An example of pansegmental colonic movements is shown in Figure 6. Patients with NET had a median of 2 (range: 1–3) pansegmental colonic movements versus 2 (range: 0–3) in healthy subjects, (P = 0.794). Median number of segments covered by pansegmental colonic movements was 3 (range: 1–4) in patients with NET and 3 (range 0–4) in healthy subjects, (P = 0.912). The median number of segments covered by each pansegmental movement was 1 (range: 1–3) in patients with NET and 1.17 (range: 1–2) in healthy subjects, (P = 0.685). The median frequency of pansegmental colonic movements was 0.45 (range: 0.03–1.02) per hour in patients with NET and 0.07 (range: 0–0.61) per hour in healthy subjects (P = 0.045). The association between the recorded colorectal transit time and frequency of pansegmental colonic movements is depicted in Figure 7.


Regional Gastrointestinal Transit Times in Patients With Carcinoid Diarrhea: Assessment With the Novel 3D-Transit System.

Gregersen T, Haase AM, Schlageter V, Gronbaek H, Krogh K - J Neurogastroenterol Motil (2015)

Trajectory of the colonic passage in a healthy subject. The 2 lines illustrate pansegmental colonic movements. The first covers the ascending colon in 22 seconds and the second covers the mid transverse colon, the descending colon and the rectosigmoid colon in 65 seconds. The dots between the 2 pansegmental movements represent slow progression through the hepatic flexure and proximal part of the transverse colon, one dot per 5 minutes.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4496908&req=5

f6-jnm-21-423: Trajectory of the colonic passage in a healthy subject. The 2 lines illustrate pansegmental colonic movements. The first covers the ascending colon in 22 seconds and the second covers the mid transverse colon, the descending colon and the rectosigmoid colon in 65 seconds. The dots between the 2 pansegmental movements represent slow progression through the hepatic flexure and proximal part of the transverse colon, one dot per 5 minutes.
Mentions: An example of pansegmental colonic movements is shown in Figure 6. Patients with NET had a median of 2 (range: 1–3) pansegmental colonic movements versus 2 (range: 0–3) in healthy subjects, (P = 0.794). Median number of segments covered by pansegmental colonic movements was 3 (range: 1–4) in patients with NET and 3 (range 0–4) in healthy subjects, (P = 0.912). The median number of segments covered by each pansegmental movement was 1 (range: 1–3) in patients with NET and 1.17 (range: 1–2) in healthy subjects, (P = 0.685). The median frequency of pansegmental colonic movements was 0.45 (range: 0.03–1.02) per hour in patients with NET and 0.07 (range: 0–0.61) per hour in healthy subjects (P = 0.045). The association between the recorded colorectal transit time and frequency of pansegmental colonic movements is depicted in Figure 7.

Bottom Line: Median colorectal transit time was 5.2 (range: 2.9-40.1) hours in patients versus 18.1 (range: 5.0-134.0) hours in healthy subjects (P = 0.012).Median frequency of pansegmental co-lonic movements was 0.45 (range: 0.03-1.02) per hour in patients and 0.07 (range: 0-0.61) per hour in healthy subjects (P = 0.045).The latter is caused by an increased frequency of pansegmental colonic movements.

View Article: PubMed Central - PubMed

Affiliation: Neurogastroenterology Unit, Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark.

ABSTRACT

Background/aims: The paucity of knowledge regarding gastrointestinal motility in patients with neuroendocrine tumors and carcinoid diarrhea re-stricts targeted treatment. 3D-Transit is a novel, minimally invasive, ambulatory method for description of gastrointestinal motility. The system has not yet been evaluated in any group of patients. We aimed to test the performance of 3D-Transit in patients with carcinoid diarrhea and to compare the patients' regional gastrointestinal transit times (GITT) and colonic motility patterns with those of healthy subjects.

Methods: Fifteen healthy volunteers and seven patients with neuroendocrine tumor and at least 3 bowel movements per day were inves-tigated with 3D-Transit and standard radiopaque markers.

Results: Total GITT assessed with 3D-Transit and radiopaque markers were well correlated (Spearman's rho = 0.64, P = 0.002). Median total GITT was 12.5 (range: 8.5-47.2) hours in patients versus 25.1 (range: 13.1-142.3) hours in healthy (P = 0.007). There was no difference in gastric emptying (P = 0.778). Median small intestinal transit time was 3.8 (range: 1.4-5.5) hours in patients versus 4.4 (range: 1.8-7.2) hours in healthy subjects (P = 0.044). Median colorectal transit time was 5.2 (range: 2.9-40.1) hours in patients versus 18.1 (range: 5.0-134.0) hours in healthy subjects (P = 0.012). Median frequency of pansegmental co-lonic movements was 0.45 (range: 0.03-1.02) per hour in patients and 0.07 (range: 0-0.61) per hour in healthy subjects (P = 0.045).

Conclusions: Three-dimensional Transit allows assessment of regional GITT in patients with diarrhea. Patients with carcinoid diarrhea have faster than normal gastrointestinal transit due to faster small intestinal and colorectal transit times. The latter is caused by an increased frequency of pansegmental colonic movements.

No MeSH data available.


Related in: MedlinePlus