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Regional Gastrointestinal Transit Times in Patients With Carcinoid Diarrhea: Assessment With the Novel 3D-Transit System.

Gregersen T, Haase AM, Schlageter V, Gronbaek H, Krogh K - J Neurogastroenterol Motil (2015)

Bottom Line: Median colorectal transit time was 5.2 (range: 2.9-40.1) hours in patients versus 18.1 (range: 5.0-134.0) hours in healthy subjects (P = 0.012).Median frequency of pansegmental co-lonic movements was 0.45 (range: 0.03-1.02) per hour in patients and 0.07 (range: 0-0.61) per hour in healthy subjects (P = 0.045).The latter is caused by an increased frequency of pansegmental colonic movements.

View Article: PubMed Central - PubMed

Affiliation: Neurogastroenterology Unit, Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark.

ABSTRACT

Background/aims: The paucity of knowledge regarding gastrointestinal motility in patients with neuroendocrine tumors and carcinoid diarrhea re-stricts targeted treatment. 3D-Transit is a novel, minimally invasive, ambulatory method for description of gastrointestinal motility. The system has not yet been evaluated in any group of patients. We aimed to test the performance of 3D-Transit in patients with carcinoid diarrhea and to compare the patients' regional gastrointestinal transit times (GITT) and colonic motility patterns with those of healthy subjects.

Methods: Fifteen healthy volunteers and seven patients with neuroendocrine tumor and at least 3 bowel movements per day were inves-tigated with 3D-Transit and standard radiopaque markers.

Results: Total GITT assessed with 3D-Transit and radiopaque markers were well correlated (Spearman's rho = 0.64, P = 0.002). Median total GITT was 12.5 (range: 8.5-47.2) hours in patients versus 25.1 (range: 13.1-142.3) hours in healthy (P = 0.007). There was no difference in gastric emptying (P = 0.778). Median small intestinal transit time was 3.8 (range: 1.4-5.5) hours in patients versus 4.4 (range: 1.8-7.2) hours in healthy subjects (P = 0.044). Median colorectal transit time was 5.2 (range: 2.9-40.1) hours in patients versus 18.1 (range: 5.0-134.0) hours in healthy subjects (P = 0.012). Median frequency of pansegmental co-lonic movements was 0.45 (range: 0.03-1.02) per hour in patients and 0.07 (range: 0-0.61) per hour in healthy subjects (P = 0.045).

Conclusions: Three-dimensional Transit allows assessment of regional GITT in patients with diarrhea. Patients with carcinoid diarrhea have faster than normal gastrointestinal transit due to faster small intestinal and colorectal transit times. The latter is caused by an increased frequency of pansegmental colonic movements.

No MeSH data available.


Related in: MedlinePlus

3D-Transit system. Electromagnetic signals from the ingestible capsule (inset) are registered by sensors in the detector plate. The detector plate and its battery are worn in an abdominal belt. A respiration belt is placed above the detector to remove respiration artefacts. Data are stored on a SD card in the detector.
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f1-jnm-21-423: 3D-Transit system. Electromagnetic signals from the ingestible capsule (inset) are registered by sensors in the detector plate. The detector plate and its battery are worn in an abdominal belt. A respiration belt is placed above the detector to remove respiration artefacts. Data are stored on a SD card in the detector.

Mentions: The 3D-Transit system is a novel, ambulatory and minimally invasive method.18 It consists of an electronic telemetric capsule for ingestion, a detector with four sensors mounted on the lower part of the abdomen, and dedicated software for real-time and post-experimental visualization and analysis (Fig. 1). The capsules (diameter 8 mm, length 21 mm, and density 1.6 g/cm3) contain an electromagnet and a battery allowing approximately 60 hours of recording at 10 Hz sampling rate or 120 hours of recording at 5 Hz sampling rate.


Regional Gastrointestinal Transit Times in Patients With Carcinoid Diarrhea: Assessment With the Novel 3D-Transit System.

Gregersen T, Haase AM, Schlageter V, Gronbaek H, Krogh K - J Neurogastroenterol Motil (2015)

3D-Transit system. Electromagnetic signals from the ingestible capsule (inset) are registered by sensors in the detector plate. The detector plate and its battery are worn in an abdominal belt. A respiration belt is placed above the detector to remove respiration artefacts. Data are stored on a SD card in the detector.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4496908&req=5

f1-jnm-21-423: 3D-Transit system. Electromagnetic signals from the ingestible capsule (inset) are registered by sensors in the detector plate. The detector plate and its battery are worn in an abdominal belt. A respiration belt is placed above the detector to remove respiration artefacts. Data are stored on a SD card in the detector.
Mentions: The 3D-Transit system is a novel, ambulatory and minimally invasive method.18 It consists of an electronic telemetric capsule for ingestion, a detector with four sensors mounted on the lower part of the abdomen, and dedicated software for real-time and post-experimental visualization and analysis (Fig. 1). The capsules (diameter 8 mm, length 21 mm, and density 1.6 g/cm3) contain an electromagnet and a battery allowing approximately 60 hours of recording at 10 Hz sampling rate or 120 hours of recording at 5 Hz sampling rate.

Bottom Line: Median colorectal transit time was 5.2 (range: 2.9-40.1) hours in patients versus 18.1 (range: 5.0-134.0) hours in healthy subjects (P = 0.012).Median frequency of pansegmental co-lonic movements was 0.45 (range: 0.03-1.02) per hour in patients and 0.07 (range: 0-0.61) per hour in healthy subjects (P = 0.045).The latter is caused by an increased frequency of pansegmental colonic movements.

View Article: PubMed Central - PubMed

Affiliation: Neurogastroenterology Unit, Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark.

ABSTRACT

Background/aims: The paucity of knowledge regarding gastrointestinal motility in patients with neuroendocrine tumors and carcinoid diarrhea re-stricts targeted treatment. 3D-Transit is a novel, minimally invasive, ambulatory method for description of gastrointestinal motility. The system has not yet been evaluated in any group of patients. We aimed to test the performance of 3D-Transit in patients with carcinoid diarrhea and to compare the patients' regional gastrointestinal transit times (GITT) and colonic motility patterns with those of healthy subjects.

Methods: Fifteen healthy volunteers and seven patients with neuroendocrine tumor and at least 3 bowel movements per day were inves-tigated with 3D-Transit and standard radiopaque markers.

Results: Total GITT assessed with 3D-Transit and radiopaque markers were well correlated (Spearman's rho = 0.64, P = 0.002). Median total GITT was 12.5 (range: 8.5-47.2) hours in patients versus 25.1 (range: 13.1-142.3) hours in healthy (P = 0.007). There was no difference in gastric emptying (P = 0.778). Median small intestinal transit time was 3.8 (range: 1.4-5.5) hours in patients versus 4.4 (range: 1.8-7.2) hours in healthy subjects (P = 0.044). Median colorectal transit time was 5.2 (range: 2.9-40.1) hours in patients versus 18.1 (range: 5.0-134.0) hours in healthy subjects (P = 0.012). Median frequency of pansegmental co-lonic movements was 0.45 (range: 0.03-1.02) per hour in patients and 0.07 (range: 0-0.61) per hour in healthy subjects (P = 0.045).

Conclusions: Three-dimensional Transit allows assessment of regional GITT in patients with diarrhea. Patients with carcinoid diarrhea have faster than normal gastrointestinal transit due to faster small intestinal and colorectal transit times. The latter is caused by an increased frequency of pansegmental colonic movements.

No MeSH data available.


Related in: MedlinePlus