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AXIN2 rs2240308 polymorphism contributes to increased cancer risk: evidence based on a meta-analysis.

Wu Z, Sun Y, Tang S, Liu C, Zhu S, Wei L, Xu H - Cancer Cell Int. (2015)

Bottom Line: Asian populations showed similar results.GA + AA: OR = 1.45, 95 % CI = 1.18-1.79.All I (2)  < 50 % and P Q  > 0.100 for heterogeneity).

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical Laboratory, Guigang City People's Hospital, 1 Zhongshan Middle Road, Guigang, 537100, Guangxi People's Republic of China.

ABSTRACT

Background: Variants in the axis inhibition 2 (AXIN2) gene might alter the protein's structure or function or create a multiprotein destruction complex in the Wnt signaling pathway and thus affect an individual's susceptibility to cancer. The objective of this study is to evaluate broadly the evidence available for the AXIN2 rs2240308 polymorphism and risk of cancer.

Methods: A comprehensive literature search was undertaken for eligible studies in Embase, PubMed, and Cochrane Library up to Nov 30, 2014. Odds ratios (ORs) and the corresponding 95 % confidence intervals (CIs) were used to measure the strength of the models.

Results: Eight articles (10 case-control studies with 1,502 cases and 1,590 controls) were included in this analysis. Overall, the AXIN2 rs2240308 polymorphism was associated with a significant increase in the risk of cancer (G allele vs. A allele: OR = 1.21, 95 % CI = 1.05-1.40, I (2)  = 39.5 % and P Q  = 0.094 for heterogeneity; GG vs. AA: OR = 1.30, 95 % CI = 1.04-1.63, I (2)  = 35.9 % and P Q  = 0.121 for heterogeneity; GG vs. GA + AA: OR = 1.36, 95 % CI = 1.17-1.58, I (2)  = 19.5 % and P Q  = 0.263 for heterogeneity). Asian populations showed similar results. Stratified analysis by cancer types indicated that the AXIN2 rs2240308 polymorphism increases the risk of lung cancer (G allele vs. A allele: OR = 1.36, 95 % CI = 1.17-1.59; GA vs. AA: OR = 1.43, 95 % CI = 1.01-2.02; GG vs. AA: OR = 1.93, 95 % CI = 1.36-2.75; GG + GA vs. AA: OR = 1.65, 95 % CI = 1.18-2.30; GG vs. GA + AA: OR = 1.45, 95 % CI = 1.18-1.79. All I (2)  < 50 % and P Q  > 0.100 for heterogeneity).

Conclusions: This study showed that the AXIN2 rs2240308 polymorphism contribute to increasing the risk of cancer, especially lung cancer in Asian populations.

No MeSH data available.


Related in: MedlinePlus

Begg’s funnel plot for contrast in overall analysis in addition model (GG vs. AA). Each point represents a separate study for the indicated association. Size graph symbol by weights. Log [OR] natural logarithm of OR. Horizontal line mean effect size
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Fig3: Begg’s funnel plot for contrast in overall analysis in addition model (GG vs. AA). Each point represents a separate study for the indicated association. Size graph symbol by weights. Log [OR] natural logarithm of OR. Horizontal line mean effect size

Mentions: To investigate publication bias in the meta-analysis, corresponding methods, including Begg’s funnel plot and Egger’s test, were conducted. The results showed that no significant publication bias was detected using Begg’s funnel plot in the overall population in all comparison models. The statistical results for Egger’s test also showed evidence of funnel plot symmetry (P > 0.05). Figure 3 shows Begg’s funnel plot in the co-dominant model (GG vs. AA, PEgger’s test = 0.551, 95 % CI = –1.84–3.21).Fig. 3


AXIN2 rs2240308 polymorphism contributes to increased cancer risk: evidence based on a meta-analysis.

Wu Z, Sun Y, Tang S, Liu C, Zhu S, Wei L, Xu H - Cancer Cell Int. (2015)

Begg’s funnel plot for contrast in overall analysis in addition model (GG vs. AA). Each point represents a separate study for the indicated association. Size graph symbol by weights. Log [OR] natural logarithm of OR. Horizontal line mean effect size
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4496878&req=5

Fig3: Begg’s funnel plot for contrast in overall analysis in addition model (GG vs. AA). Each point represents a separate study for the indicated association. Size graph symbol by weights. Log [OR] natural logarithm of OR. Horizontal line mean effect size
Mentions: To investigate publication bias in the meta-analysis, corresponding methods, including Begg’s funnel plot and Egger’s test, were conducted. The results showed that no significant publication bias was detected using Begg’s funnel plot in the overall population in all comparison models. The statistical results for Egger’s test also showed evidence of funnel plot symmetry (P > 0.05). Figure 3 shows Begg’s funnel plot in the co-dominant model (GG vs. AA, PEgger’s test = 0.551, 95 % CI = –1.84–3.21).Fig. 3

Bottom Line: Asian populations showed similar results.GA + AA: OR = 1.45, 95 % CI = 1.18-1.79.All I (2)  < 50 % and P Q  > 0.100 for heterogeneity).

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical Laboratory, Guigang City People's Hospital, 1 Zhongshan Middle Road, Guigang, 537100, Guangxi People's Republic of China.

ABSTRACT

Background: Variants in the axis inhibition 2 (AXIN2) gene might alter the protein's structure or function or create a multiprotein destruction complex in the Wnt signaling pathway and thus affect an individual's susceptibility to cancer. The objective of this study is to evaluate broadly the evidence available for the AXIN2 rs2240308 polymorphism and risk of cancer.

Methods: A comprehensive literature search was undertaken for eligible studies in Embase, PubMed, and Cochrane Library up to Nov 30, 2014. Odds ratios (ORs) and the corresponding 95 % confidence intervals (CIs) were used to measure the strength of the models.

Results: Eight articles (10 case-control studies with 1,502 cases and 1,590 controls) were included in this analysis. Overall, the AXIN2 rs2240308 polymorphism was associated with a significant increase in the risk of cancer (G allele vs. A allele: OR = 1.21, 95 % CI = 1.05-1.40, I (2)  = 39.5 % and P Q  = 0.094 for heterogeneity; GG vs. AA: OR = 1.30, 95 % CI = 1.04-1.63, I (2)  = 35.9 % and P Q  = 0.121 for heterogeneity; GG vs. GA + AA: OR = 1.36, 95 % CI = 1.17-1.58, I (2)  = 19.5 % and P Q  = 0.263 for heterogeneity). Asian populations showed similar results. Stratified analysis by cancer types indicated that the AXIN2 rs2240308 polymorphism increases the risk of lung cancer (G allele vs. A allele: OR = 1.36, 95 % CI = 1.17-1.59; GA vs. AA: OR = 1.43, 95 % CI = 1.01-2.02; GG vs. AA: OR = 1.93, 95 % CI = 1.36-2.75; GG + GA vs. AA: OR = 1.65, 95 % CI = 1.18-2.30; GG vs. GA + AA: OR = 1.45, 95 % CI = 1.18-1.79. All I (2)  < 50 % and P Q  > 0.100 for heterogeneity).

Conclusions: This study showed that the AXIN2 rs2240308 polymorphism contribute to increasing the risk of cancer, especially lung cancer in Asian populations.

No MeSH data available.


Related in: MedlinePlus