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Study of cardiovascular disease biomarkers among tobacco consumers. Part 3: evaluation and comparison with the US National Health and Nutrition Examination Survey.

Marano KM, Kathman SJ, Jones BA, Nordskog BK, Brown BG, Borgerding MF - Inhal Toxicol (2015)

Bottom Line: Cardiovascular disease (CVD) biomarkers of biological effect (BoBE), including hematologic biomarkers, serum lipid-related biomarkers, other serum BoBE, and one physiological biomarker, were evaluated in adult cigarette smokers (SMK), smokeless tobacco consumers (STC), and non-consumers of tobacco (NTC).Data from adult males and females in the US National Health and Nutrition Examination Survey and a single site, cross-sectional study of healthy US males were analyzed and compared.Results provide evidence for differences in CVD BoBE associated with the use of different tobacco products, and provide evidence of a risk continuum among tobacco products and support for the concept of tobacco harm reduction.

View Article: PubMed Central - PubMed

Affiliation: RAI Services Company, Winston-Salem, NC , USA and.

ABSTRACT
Cardiovascular disease (CVD) biomarkers of biological effect (BoBE), including hematologic biomarkers, serum lipid-related biomarkers, other serum BoBE, and one physiological biomarker, were evaluated in adult cigarette smokers (SMK), smokeless tobacco consumers (STC), and non-consumers of tobacco (NTC). Data from adult males and females in the US National Health and Nutrition Examination Survey and a single site, cross-sectional study of healthy US males were analyzed and compared. Within normal clinical reference ranges, statistically significant differences were observed consistently for fibrinogen, C-reactive protein (CRP), hematocrit, mean cell volume, mean cell hemoglobin, hemoglobin, white blood cells, monocytes, lymphocytes, and neutrophils in comparisons between SMK and NTC; for CRP, white blood cells, monocytes, and lymphocytes in comparisons between SMK and STC; and for folate in comparisons with STC and NTC. Results provide evidence for differences in CVD BoBE associated with the use of different tobacco products, and provide evidence of a risk continuum among tobacco products and support for the concept of tobacco harm reduction.

No MeSH data available.


Related in: MedlinePlus

Biomarkers of biological effect with statistically significant differences between tobacco consumption groups in all three data sets. Results are fold-differences (i.e. multiplicative factors to the geometric mean) and 95% confidence intervals between exposure groups from Data set 1. Statistically significant = 95% confidence interval did not include 1.00. SMK, cigarette smokers; STC, smokeless tobacco consumers; NTC, non-consumers of tobacco.
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Figure 0001: Biomarkers of biological effect with statistically significant differences between tobacco consumption groups in all three data sets. Results are fold-differences (i.e. multiplicative factors to the geometric mean) and 95% confidence intervals between exposure groups from Data set 1. Statistically significant = 95% confidence interval did not include 1.00. SMK, cigarette smokers; STC, smokeless tobacco consumers; NTC, non-consumers of tobacco.

Mentions: Statistically significantly higher levels of fibrinogen (<10%), CRP (30 to >100%), hematocrit (<5%), mean cell volume (<5%), mean cell hemoglobin (<5%), hemoglobin (<5%), white blood cells (∼20%), monocytes (10–15%), lymphocytes (20%), and neutrophils (20–49%) were observed consistently across all three data sets in comparisons of SMK versus NTC (Table 4, Figure 1, and Supplementary Tables S-5–S-7); statistically significantly lower levels folate (15–20%) and ABI measures (3–5%) were also observed consistently across the three data sets in SMK versus NTC. HDL level was statistically significantly lower (5–11%) in two of the three data sets (Data sets 1 and 3), and not statistically significantly lower (2%) in Data set 2. Eosinophil counts were statistically significantly higher (30–32%) in two of the three data sets (Data sets 1 and 2), and not statistically significantly different in Data set 3. Total cholesterol (1%), platelets (3%), and red cell distribution width (1%) were statistically significantly higher in SMK versus NTC in Data set 1, but not in the other two data sets.Figure 1.


Study of cardiovascular disease biomarkers among tobacco consumers. Part 3: evaluation and comparison with the US National Health and Nutrition Examination Survey.

Marano KM, Kathman SJ, Jones BA, Nordskog BK, Brown BG, Borgerding MF - Inhal Toxicol (2015)

Biomarkers of biological effect with statistically significant differences between tobacco consumption groups in all three data sets. Results are fold-differences (i.e. multiplicative factors to the geometric mean) and 95% confidence intervals between exposure groups from Data set 1. Statistically significant = 95% confidence interval did not include 1.00. SMK, cigarette smokers; STC, smokeless tobacco consumers; NTC, non-consumers of tobacco.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4496809&req=5

Figure 0001: Biomarkers of biological effect with statistically significant differences between tobacco consumption groups in all three data sets. Results are fold-differences (i.e. multiplicative factors to the geometric mean) and 95% confidence intervals between exposure groups from Data set 1. Statistically significant = 95% confidence interval did not include 1.00. SMK, cigarette smokers; STC, smokeless tobacco consumers; NTC, non-consumers of tobacco.
Mentions: Statistically significantly higher levels of fibrinogen (<10%), CRP (30 to >100%), hematocrit (<5%), mean cell volume (<5%), mean cell hemoglobin (<5%), hemoglobin (<5%), white blood cells (∼20%), monocytes (10–15%), lymphocytes (20%), and neutrophils (20–49%) were observed consistently across all three data sets in comparisons of SMK versus NTC (Table 4, Figure 1, and Supplementary Tables S-5–S-7); statistically significantly lower levels folate (15–20%) and ABI measures (3–5%) were also observed consistently across the three data sets in SMK versus NTC. HDL level was statistically significantly lower (5–11%) in two of the three data sets (Data sets 1 and 3), and not statistically significantly lower (2%) in Data set 2. Eosinophil counts were statistically significantly higher (30–32%) in two of the three data sets (Data sets 1 and 2), and not statistically significantly different in Data set 3. Total cholesterol (1%), platelets (3%), and red cell distribution width (1%) were statistically significantly higher in SMK versus NTC in Data set 1, but not in the other two data sets.Figure 1.

Bottom Line: Cardiovascular disease (CVD) biomarkers of biological effect (BoBE), including hematologic biomarkers, serum lipid-related biomarkers, other serum BoBE, and one physiological biomarker, were evaluated in adult cigarette smokers (SMK), smokeless tobacco consumers (STC), and non-consumers of tobacco (NTC).Data from adult males and females in the US National Health and Nutrition Examination Survey and a single site, cross-sectional study of healthy US males were analyzed and compared.Results provide evidence for differences in CVD BoBE associated with the use of different tobacco products, and provide evidence of a risk continuum among tobacco products and support for the concept of tobacco harm reduction.

View Article: PubMed Central - PubMed

Affiliation: RAI Services Company, Winston-Salem, NC , USA and.

ABSTRACT
Cardiovascular disease (CVD) biomarkers of biological effect (BoBE), including hematologic biomarkers, serum lipid-related biomarkers, other serum BoBE, and one physiological biomarker, were evaluated in adult cigarette smokers (SMK), smokeless tobacco consumers (STC), and non-consumers of tobacco (NTC). Data from adult males and females in the US National Health and Nutrition Examination Survey and a single site, cross-sectional study of healthy US males were analyzed and compared. Within normal clinical reference ranges, statistically significant differences were observed consistently for fibrinogen, C-reactive protein (CRP), hematocrit, mean cell volume, mean cell hemoglobin, hemoglobin, white blood cells, monocytes, lymphocytes, and neutrophils in comparisons between SMK and NTC; for CRP, white blood cells, monocytes, and lymphocytes in comparisons between SMK and STC; and for folate in comparisons with STC and NTC. Results provide evidence for differences in CVD BoBE associated with the use of different tobacco products, and provide evidence of a risk continuum among tobacco products and support for the concept of tobacco harm reduction.

No MeSH data available.


Related in: MedlinePlus