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Effect of cigarette design on biomarkers of exposure, puffing topography and respiratory parameters.

Appleton S, Liu J, Lipowicz PJ, Sarkar M - Inhal Toxicol (2015)

Bottom Line: Post-baseline NE and COHb were statistically significantly lower in the TCL compared to the TCH groups.Under the conditions of this study, we found no indication of changes in respiratory parameters, particularly inhalation time and volume, between study participants smoking lower versus higher yield cigarettes.These findings are consistent with the published literature indicating smoking low-yield cigarettes does not increase the depth of inhalation.

View Article: PubMed Central - PubMed

Affiliation: Altria Client Services Inc. , Richmond, VA , USA.

ABSTRACT
Despite the lack of evidence, many reports exist which have implied that smokers inhale low-yield cigarette smoke more deeply than that of high-yield cigarettes. The objective of this study was to investigate the effect of short-term switching between smoker's own brand and test cigarettes with different smoke yields on puffing topography, respiratory parameters and biomarkers of exposure. Participants were randomly assigned to smoke either a Test Cigarette-High Tar (TCH), for two days, and then switched to a Test Cigarette-Low Tar (TCL), for two days or the reverse order (nā€‰=ā€‰10 each sequence). Puffing topography (CReSS microdevice), respiratory parameters (inductive plethysmography) and biomarkers of exposure (BOE, urinary nicotine equivalents - NE and blood carboxyhemoglobin - COHb) were measured at baseline and on days 2 and 4. The average puffs per cigarette, puff volume and puff durations were statistically significantly lower, and inter-puff interval was significantly longer for the TCH compared to the TCL groups. Respiratory parameters were not statistically significantly different between the TCH and TCL groups. Post-baseline NE and COHb were statistically significantly lower in the TCL compared to the TCH groups. Under the conditions of this study, we found no indication of changes in respiratory parameters, particularly inhalation time and volume, between study participants smoking lower versus higher yield cigarettes. Likewise, the BOE provides no indication of deeper inhalation when smoking low- versus high-yield cigarettes. These findings are consistent with the published literature indicating smoking low-yield cigarettes does not increase the depth of inhalation.

No MeSH data available.


Related in: MedlinePlus

Respiratory patterns.
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Figure 0002: Respiratory patterns.

Mentions: Two major breathing patterns were identified, which represented approximately 90% of the breathing episodes recorded during the study (Figure 2). The distribution of pattern I and pattern II is presented in Table 3. The distribution of the two patterns was similar for TCH and TCL, no statistical analyses were performed due to the large variability. All the inhalation and exhalation parameters (average inhalation volume, average inhalation time, average exhalation volume, average exhalation time and average breath-holding time) were not statistically significantly different between the TCH and TCL groups.Figure 2.


Effect of cigarette design on biomarkers of exposure, puffing topography and respiratory parameters.

Appleton S, Liu J, Lipowicz PJ, Sarkar M - Inhal Toxicol (2015)

Respiratory patterns.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4496805&req=5

Figure 0002: Respiratory patterns.
Mentions: Two major breathing patterns were identified, which represented approximately 90% of the breathing episodes recorded during the study (Figure 2). The distribution of pattern I and pattern II is presented in Table 3. The distribution of the two patterns was similar for TCH and TCL, no statistical analyses were performed due to the large variability. All the inhalation and exhalation parameters (average inhalation volume, average inhalation time, average exhalation volume, average exhalation time and average breath-holding time) were not statistically significantly different between the TCH and TCL groups.Figure 2.

Bottom Line: Post-baseline NE and COHb were statistically significantly lower in the TCL compared to the TCH groups.Under the conditions of this study, we found no indication of changes in respiratory parameters, particularly inhalation time and volume, between study participants smoking lower versus higher yield cigarettes.These findings are consistent with the published literature indicating smoking low-yield cigarettes does not increase the depth of inhalation.

View Article: PubMed Central - PubMed

Affiliation: Altria Client Services Inc. , Richmond, VA , USA.

ABSTRACT
Despite the lack of evidence, many reports exist which have implied that smokers inhale low-yield cigarette smoke more deeply than that of high-yield cigarettes. The objective of this study was to investigate the effect of short-term switching between smoker's own brand and test cigarettes with different smoke yields on puffing topography, respiratory parameters and biomarkers of exposure. Participants were randomly assigned to smoke either a Test Cigarette-High Tar (TCH), for two days, and then switched to a Test Cigarette-Low Tar (TCL), for two days or the reverse order (nā€‰=ā€‰10 each sequence). Puffing topography (CReSS microdevice), respiratory parameters (inductive plethysmography) and biomarkers of exposure (BOE, urinary nicotine equivalents - NE and blood carboxyhemoglobin - COHb) were measured at baseline and on days 2 and 4. The average puffs per cigarette, puff volume and puff durations were statistically significantly lower, and inter-puff interval was significantly longer for the TCH compared to the TCL groups. Respiratory parameters were not statistically significantly different between the TCH and TCL groups. Post-baseline NE and COHb were statistically significantly lower in the TCL compared to the TCH groups. Under the conditions of this study, we found no indication of changes in respiratory parameters, particularly inhalation time and volume, between study participants smoking lower versus higher yield cigarettes. Likewise, the BOE provides no indication of deeper inhalation when smoking low- versus high-yield cigarettes. These findings are consistent with the published literature indicating smoking low-yield cigarettes does not increase the depth of inhalation.

No MeSH data available.


Related in: MedlinePlus