Limits...
Effect of cigarette design on biomarkers of exposure, puffing topography and respiratory parameters.

Appleton S, Liu J, Lipowicz PJ, Sarkar M - Inhal Toxicol (2015)

Bottom Line: Post-baseline NE and COHb were statistically significantly lower in the TCL compared to the TCH groups.Under the conditions of this study, we found no indication of changes in respiratory parameters, particularly inhalation time and volume, between study participants smoking lower versus higher yield cigarettes.These findings are consistent with the published literature indicating smoking low-yield cigarettes does not increase the depth of inhalation.

View Article: PubMed Central - PubMed

Affiliation: Altria Client Services Inc. , Richmond, VA , USA.

ABSTRACT
Despite the lack of evidence, many reports exist which have implied that smokers inhale low-yield cigarette smoke more deeply than that of high-yield cigarettes. The objective of this study was to investigate the effect of short-term switching between smoker's own brand and test cigarettes with different smoke yields on puffing topography, respiratory parameters and biomarkers of exposure. Participants were randomly assigned to smoke either a Test Cigarette-High Tar (TCH), for two days, and then switched to a Test Cigarette-Low Tar (TCL), for two days or the reverse order (nā€‰=ā€‰10 each sequence). Puffing topography (CReSS microdevice), respiratory parameters (inductive plethysmography) and biomarkers of exposure (BOE, urinary nicotine equivalents - NE and blood carboxyhemoglobin - COHb) were measured at baseline and on days 2 and 4. The average puffs per cigarette, puff volume and puff durations were statistically significantly lower, and inter-puff interval was significantly longer for the TCH compared to the TCL groups. Respiratory parameters were not statistically significantly different between the TCH and TCL groups. Post-baseline NE and COHb were statistically significantly lower in the TCL compared to the TCH groups. Under the conditions of this study, we found no indication of changes in respiratory parameters, particularly inhalation time and volume, between study participants smoking lower versus higher yield cigarettes. Likewise, the BOE provides no indication of deeper inhalation when smoking low- versus high-yield cigarettes. These findings are consistent with the published literature indicating smoking low-yield cigarettes does not increase the depth of inhalation.

No MeSH data available.


Related in: MedlinePlus

Schematic representation of randomized open-label study design.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4496805&req=5

Figure 0001: Schematic representation of randomized open-label study design.

Mentions: The study design is illustrated in Figure 1. This was a randomized, controlled, double-blind, 2-way crossover study with three consecutive recording periods: Baseline (one day), Period 1 (2 days) and Period 2 (2 days). Subjects were allowed to stay in the clinic during the entire study period.Figure 1.


Effect of cigarette design on biomarkers of exposure, puffing topography and respiratory parameters.

Appleton S, Liu J, Lipowicz PJ, Sarkar M - Inhal Toxicol (2015)

Schematic representation of randomized open-label study design.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4496805&req=5

Figure 0001: Schematic representation of randomized open-label study design.
Mentions: The study design is illustrated in Figure 1. This was a randomized, controlled, double-blind, 2-way crossover study with three consecutive recording periods: Baseline (one day), Period 1 (2 days) and Period 2 (2 days). Subjects were allowed to stay in the clinic during the entire study period.Figure 1.

Bottom Line: Post-baseline NE and COHb were statistically significantly lower in the TCL compared to the TCH groups.Under the conditions of this study, we found no indication of changes in respiratory parameters, particularly inhalation time and volume, between study participants smoking lower versus higher yield cigarettes.These findings are consistent with the published literature indicating smoking low-yield cigarettes does not increase the depth of inhalation.

View Article: PubMed Central - PubMed

Affiliation: Altria Client Services Inc. , Richmond, VA , USA.

ABSTRACT
Despite the lack of evidence, many reports exist which have implied that smokers inhale low-yield cigarette smoke more deeply than that of high-yield cigarettes. The objective of this study was to investigate the effect of short-term switching between smoker's own brand and test cigarettes with different smoke yields on puffing topography, respiratory parameters and biomarkers of exposure. Participants were randomly assigned to smoke either a Test Cigarette-High Tar (TCH), for two days, and then switched to a Test Cigarette-Low Tar (TCL), for two days or the reverse order (nā€‰=ā€‰10 each sequence). Puffing topography (CReSS microdevice), respiratory parameters (inductive plethysmography) and biomarkers of exposure (BOE, urinary nicotine equivalents - NE and blood carboxyhemoglobin - COHb) were measured at baseline and on days 2 and 4. The average puffs per cigarette, puff volume and puff durations were statistically significantly lower, and inter-puff interval was significantly longer for the TCH compared to the TCL groups. Respiratory parameters were not statistically significantly different between the TCH and TCL groups. Post-baseline NE and COHb were statistically significantly lower in the TCL compared to the TCH groups. Under the conditions of this study, we found no indication of changes in respiratory parameters, particularly inhalation time and volume, between study participants smoking lower versus higher yield cigarettes. Likewise, the BOE provides no indication of deeper inhalation when smoking low- versus high-yield cigarettes. These findings are consistent with the published literature indicating smoking low-yield cigarettes does not increase the depth of inhalation.

No MeSH data available.


Related in: MedlinePlus