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Clinical Effect of Shenfu Injection in Patients with Septic Shock: A Meta-Analysis and Systematic Review.

Mou Z, Lv Z, Li Y, Wang M, Xu Q, Yu X - Evid Based Complement Alternat Med (2015)

Bottom Line: As the endpoint of mortality was not unified, it was not meta-analyzed.Conclusions.Based on the findings in present review, Shenfu injection is more effective than conventional therapy in increasing mean arterial pressure, normalizing heart rate, clearing serum lactate, and reducing mortality.

View Article: PubMed Central - PubMed

Affiliation: Emergency Department, Peking Union Medical College Hospital, Beijing 100730, China.

ABSTRACT
Purpose. To conduct a meta-analysis evaluating the efficacy of Shenfu injection for treating patients with septic shock when compared with conventional therapy. Methods. Eight databases including Pubmed, EMBASE, Cochrane Library, ISI Web of Science, CNKI, Wanfang, VIP, and CBM were searched up to October 2014. Randomized controlled trials assessing the efficacy of Shenfu injection were identified. Mean arterial pressure, heart rate, lactate, and mortality were included as outcome measurements. Results. We analyzed data from 12 randomized controlled trials involving 904 participants. Compared with conventional therapy, Shenfu injection could further increase the mean arterial pressure at 1 hour (SMD 0.38; 95% CI, 0.01-0.74) and 6 hours (SMD 0.82; 95% CI, 0.03-1.61). Shenfu injection could further normalize heart rate at 6 hours (SMD -0.90; 95% CI, -1.47-0.33) and clear serum lactate at 6 hours (SMD -0.51; 95% CI, -0.70-0.32) and 24 hours (SMD, 0.52; 95% CI, -0.77-0.26). As the endpoint of mortality was not unified, it was not meta-analyzed. Conclusions. Based on the findings in present review, Shenfu injection is more effective than conventional therapy in increasing mean arterial pressure, normalizing heart rate, clearing serum lactate, and reducing mortality. These results should be confirmed in higher level clinical trials in the future.

No MeSH data available.


Related in: MedlinePlus

Funnel plot of Shenfu injection plus conventional therapy versus conventional therapy: HR.
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Related In: Results  -  Collection


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fig6: Funnel plot of Shenfu injection plus conventional therapy versus conventional therapy: HR.

Mentions: The publication bias was explored via funnel plots (Figures 5, 6, and 7). Points in Figures 5 and 6 presented asymmetry suggesting the possibility of publication bias. Points in Figure 7 seemed to be symmetric, which indicates no obvious publication bias. Given that all these selected articles were published in Chinese academic journals, the potential of publication bias could not be excluded.


Clinical Effect of Shenfu Injection in Patients with Septic Shock: A Meta-Analysis and Systematic Review.

Mou Z, Lv Z, Li Y, Wang M, Xu Q, Yu X - Evid Based Complement Alternat Med (2015)

Funnel plot of Shenfu injection plus conventional therapy versus conventional therapy: HR.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4496657&req=5

fig6: Funnel plot of Shenfu injection plus conventional therapy versus conventional therapy: HR.
Mentions: The publication bias was explored via funnel plots (Figures 5, 6, and 7). Points in Figures 5 and 6 presented asymmetry suggesting the possibility of publication bias. Points in Figure 7 seemed to be symmetric, which indicates no obvious publication bias. Given that all these selected articles were published in Chinese academic journals, the potential of publication bias could not be excluded.

Bottom Line: As the endpoint of mortality was not unified, it was not meta-analyzed.Conclusions.Based on the findings in present review, Shenfu injection is more effective than conventional therapy in increasing mean arterial pressure, normalizing heart rate, clearing serum lactate, and reducing mortality.

View Article: PubMed Central - PubMed

Affiliation: Emergency Department, Peking Union Medical College Hospital, Beijing 100730, China.

ABSTRACT
Purpose. To conduct a meta-analysis evaluating the efficacy of Shenfu injection for treating patients with septic shock when compared with conventional therapy. Methods. Eight databases including Pubmed, EMBASE, Cochrane Library, ISI Web of Science, CNKI, Wanfang, VIP, and CBM were searched up to October 2014. Randomized controlled trials assessing the efficacy of Shenfu injection were identified. Mean arterial pressure, heart rate, lactate, and mortality were included as outcome measurements. Results. We analyzed data from 12 randomized controlled trials involving 904 participants. Compared with conventional therapy, Shenfu injection could further increase the mean arterial pressure at 1 hour (SMD 0.38; 95% CI, 0.01-0.74) and 6 hours (SMD 0.82; 95% CI, 0.03-1.61). Shenfu injection could further normalize heart rate at 6 hours (SMD -0.90; 95% CI, -1.47-0.33) and clear serum lactate at 6 hours (SMD -0.51; 95% CI, -0.70-0.32) and 24 hours (SMD, 0.52; 95% CI, -0.77-0.26). As the endpoint of mortality was not unified, it was not meta-analyzed. Conclusions. Based on the findings in present review, Shenfu injection is more effective than conventional therapy in increasing mean arterial pressure, normalizing heart rate, clearing serum lactate, and reducing mortality. These results should be confirmed in higher level clinical trials in the future.

No MeSH data available.


Related in: MedlinePlus