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Synthesis, Characterization, and Anticancer Activity of New Metal Complexes Derived from 2-Hydroxy-3-(hydroxyimino)-4-oxopentan-2-ylidene)benzohydrazide.

El-Tabl AS, Mohamed Abd El-Waheed M, Wahba MA, Abd El-Halim Abou El-Fadl N - Bioinorg Chem Appl (2015)

Bottom Line: The ESR spectra of the solid copper(II) complexes are characteristic to d(9) configuration and have an axial symmetry type of a d(x (2)-y (2)) ground state.The g values confirmed the tetragonal octahedral geometry with a considerably ionic or covalent environment.The cytotoxic activity of the ligand and its metal complexes showed potent cytotoxicity effect against growth of human liver cancer HepG2 cell lines compared to the clinically used Sorafenib (Nexavar).

View Article: PubMed Central - PubMed

Affiliation: Department of Chemistry, Faculty of Science, Menoufia University, P.O. Box 5744, Shibin Al Kawm, Egypt.

ABSTRACT
Novel metal(II) complexes derived from 2-hydroxy-N'-((Z)-3-(hydroxyimino)-4-oxopentan-2-ylidene)benzohydrazide ligand (H2L) were synthesized and characterized by elemental and thermal analyses (DTA and TGA), IR, UV-VIS, (1)H-NMR, ESR and mass spectroscopy, magnetic susceptibilities, and conductivities measurements. The complexes adopt distorted octahedral geometry. The ESR spectra of the solid copper(II) complexes are characteristic to d(9) configuration and have an axial symmetry type of a d(x (2)-y (2)) ground state. The g values confirmed the tetragonal octahedral geometry with a considerably ionic or covalent environment. The cytotoxic activity of the ligand and its metal complexes showed potent cytotoxicity effect against growth of human liver cancer HepG2 cell lines compared to the clinically used Sorafenib (Nexavar).

No MeSH data available.


Related in: MedlinePlus

Proposed structures of the ligand [H2L] and its metal complexes.
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fig2: Proposed structures of the ligand [H2L] and its metal complexes.

Mentions: All complexes are colored, stable at room temperature, nonhygroscopic, partially soluble in common organic solvents such as CHCl3, and appreciably soluble in DMF and DMSO. The analytical and physical data (Table 1) and spectral data (Tables 2–4) are compatible with the proposed structures (Figure 2). Many attempts have been made to grow up single crystal but no diffractable crystals have been grown till now. The molar conductances of the complexes in 10−3 M DMF at 25°C are in the 13.0–33.4 ohm−1 cm2 mol−1 range, indicating a nonelectrolytic nature [26, 27]. The relative high values for some complexes suggest partial dissociation in DMF. The elemental analyses indicated that, all complexes were formed in 1 L : 1 M molar ratio, except complex (3) which is found to be formed in 1 L : 2 M molar ratio.


Synthesis, Characterization, and Anticancer Activity of New Metal Complexes Derived from 2-Hydroxy-3-(hydroxyimino)-4-oxopentan-2-ylidene)benzohydrazide.

El-Tabl AS, Mohamed Abd El-Waheed M, Wahba MA, Abd El-Halim Abou El-Fadl N - Bioinorg Chem Appl (2015)

Proposed structures of the ligand [H2L] and its metal complexes.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4496588&req=5

fig2: Proposed structures of the ligand [H2L] and its metal complexes.
Mentions: All complexes are colored, stable at room temperature, nonhygroscopic, partially soluble in common organic solvents such as CHCl3, and appreciably soluble in DMF and DMSO. The analytical and physical data (Table 1) and spectral data (Tables 2–4) are compatible with the proposed structures (Figure 2). Many attempts have been made to grow up single crystal but no diffractable crystals have been grown till now. The molar conductances of the complexes in 10−3 M DMF at 25°C are in the 13.0–33.4 ohm−1 cm2 mol−1 range, indicating a nonelectrolytic nature [26, 27]. The relative high values for some complexes suggest partial dissociation in DMF. The elemental analyses indicated that, all complexes were formed in 1 L : 1 M molar ratio, except complex (3) which is found to be formed in 1 L : 2 M molar ratio.

Bottom Line: The ESR spectra of the solid copper(II) complexes are characteristic to d(9) configuration and have an axial symmetry type of a d(x (2)-y (2)) ground state.The g values confirmed the tetragonal octahedral geometry with a considerably ionic or covalent environment.The cytotoxic activity of the ligand and its metal complexes showed potent cytotoxicity effect against growth of human liver cancer HepG2 cell lines compared to the clinically used Sorafenib (Nexavar).

View Article: PubMed Central - PubMed

Affiliation: Department of Chemistry, Faculty of Science, Menoufia University, P.O. Box 5744, Shibin Al Kawm, Egypt.

ABSTRACT
Novel metal(II) complexes derived from 2-hydroxy-N'-((Z)-3-(hydroxyimino)-4-oxopentan-2-ylidene)benzohydrazide ligand (H2L) were synthesized and characterized by elemental and thermal analyses (DTA and TGA), IR, UV-VIS, (1)H-NMR, ESR and mass spectroscopy, magnetic susceptibilities, and conductivities measurements. The complexes adopt distorted octahedral geometry. The ESR spectra of the solid copper(II) complexes are characteristic to d(9) configuration and have an axial symmetry type of a d(x (2)-y (2)) ground state. The g values confirmed the tetragonal octahedral geometry with a considerably ionic or covalent environment. The cytotoxic activity of the ligand and its metal complexes showed potent cytotoxicity effect against growth of human liver cancer HepG2 cell lines compared to the clinically used Sorafenib (Nexavar).

No MeSH data available.


Related in: MedlinePlus