Limits...
Formulation and evaluation of bilayer tablet for bimodal release of venlafaxine hydrochloride.

Momin MM, Kane S, Abhang P - Front Pharmacol (2015)

Bottom Line: The selected responses, bioadhesion force (0.11-0.25 ± 0.023 g), amount of drug released in 10 h, Y10 (78.20-95.78 ± 1.24%) and bioadhesive strength, (19-24 ± 2 h) presented good correlation with the selected independent variables.Statistical analysis (ANOVA) of the optimized bilayer formulations showed no significant difference in the cumulative amount of drug release after 15 min, but significant difference (p < 0.05) in the amount of drug released after 1 hr till 12 h from optimized formulations was observed.The natural mucilage like FNM could be successfully incorporated into tablet with only 20% replacement with HPMC and it showed good bioadhesiveness and sustained drug release.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutics, SVKM's Dr. Bhanuben Nanavati College of Pharmacy Mumbai, India.

ABSTRACT
The aim of the present research was to develop a bilayer tablet of venlafaxine hydrochloride for bimodal drug release. In the present investigation authors have tried to explore fenugreek mucilage (FNM) for bioadhesive sustained release layer. The attempt has been made to combine FNM with well studied bioadhesive polymers like hydroxy propyl methyl cellulose (HPMC), Carbopol, and Xanthan Gum. The formulations were evaluated for swelling Index, ex vivo bioadhesion, water uptake studies, in vitro drug release and dissolution kinetics was studied. Substantial bioadhesion force (2.4 ± 0.023 g) and tablet adhesion retention time (24 ± 2 h) was observed with FNM and HPMC combination at 80:20 ratio. The dissolution kinetics followed the Higuchi model (R (2) = 0.9913) via a non-Fickian diffusion controlled release mechanism after the initial burst. The 3(2) full factorial design was employed in the present study. The type of polymers used in combination with FNM (X1) and percent polymer replaced with FNM (X2) were taken as independent formulations variables. The selected responses, bioadhesion force (0.11-0.25 ± 0.023 g), amount of drug released in 10 h, Y10 (78.20-95.78 ± 1.24%) and bioadhesive strength, (19-24 ± 2 h) presented good correlation with the selected independent variables. Statistical analysis (ANOVA) of the optimized bilayer formulations showed no significant difference in the cumulative amount of drug release after 15 min, but significant difference (p < 0.05) in the amount of drug released after 1 hr till 12 h from optimized formulations was observed. The natural mucilage like FNM could be successfully incorporated into tablet with only 20% replacement with HPMC and it showed good bioadhesiveness and sustained drug release.

No MeSH data available.


Related in: MedlinePlus

comparison of marketed product and optimized batch BF7.
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4496574&req=5

Figure 6: comparison of marketed product and optimized batch BF7.

Mentions: The optimized immediate layer (B6) and sustained release layer (F6) were compressed to get bilayer tablet. The resultant bilayer tablet (BF7) was subjected to in vitro dissolution studies. The Figure 6 indicates the initial burst effect due to immediate release layer of VFX and then slow release of the drug is maintained as per the Higuchi model of drug release kinetics till 12 h. It release up to 95 ± 0.5% drug after 12 h. Drug release profile of the optimized formulations was compared with the marketed brands of once-a-day formulations, Venlor XR each containing 75 mg of venlafaxine hydrochloride per tablet (Figure 6).


Formulation and evaluation of bilayer tablet for bimodal release of venlafaxine hydrochloride.

Momin MM, Kane S, Abhang P - Front Pharmacol (2015)

comparison of marketed product and optimized batch BF7.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4496574&req=5

Figure 6: comparison of marketed product and optimized batch BF7.
Mentions: The optimized immediate layer (B6) and sustained release layer (F6) were compressed to get bilayer tablet. The resultant bilayer tablet (BF7) was subjected to in vitro dissolution studies. The Figure 6 indicates the initial burst effect due to immediate release layer of VFX and then slow release of the drug is maintained as per the Higuchi model of drug release kinetics till 12 h. It release up to 95 ± 0.5% drug after 12 h. Drug release profile of the optimized formulations was compared with the marketed brands of once-a-day formulations, Venlor XR each containing 75 mg of venlafaxine hydrochloride per tablet (Figure 6).

Bottom Line: The selected responses, bioadhesion force (0.11-0.25 ± 0.023 g), amount of drug released in 10 h, Y10 (78.20-95.78 ± 1.24%) and bioadhesive strength, (19-24 ± 2 h) presented good correlation with the selected independent variables.Statistical analysis (ANOVA) of the optimized bilayer formulations showed no significant difference in the cumulative amount of drug release after 15 min, but significant difference (p < 0.05) in the amount of drug released after 1 hr till 12 h from optimized formulations was observed.The natural mucilage like FNM could be successfully incorporated into tablet with only 20% replacement with HPMC and it showed good bioadhesiveness and sustained drug release.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutics, SVKM's Dr. Bhanuben Nanavati College of Pharmacy Mumbai, India.

ABSTRACT
The aim of the present research was to develop a bilayer tablet of venlafaxine hydrochloride for bimodal drug release. In the present investigation authors have tried to explore fenugreek mucilage (FNM) for bioadhesive sustained release layer. The attempt has been made to combine FNM with well studied bioadhesive polymers like hydroxy propyl methyl cellulose (HPMC), Carbopol, and Xanthan Gum. The formulations were evaluated for swelling Index, ex vivo bioadhesion, water uptake studies, in vitro drug release and dissolution kinetics was studied. Substantial bioadhesion force (2.4 ± 0.023 g) and tablet adhesion retention time (24 ± 2 h) was observed with FNM and HPMC combination at 80:20 ratio. The dissolution kinetics followed the Higuchi model (R (2) = 0.9913) via a non-Fickian diffusion controlled release mechanism after the initial burst. The 3(2) full factorial design was employed in the present study. The type of polymers used in combination with FNM (X1) and percent polymer replaced with FNM (X2) were taken as independent formulations variables. The selected responses, bioadhesion force (0.11-0.25 ± 0.023 g), amount of drug released in 10 h, Y10 (78.20-95.78 ± 1.24%) and bioadhesive strength, (19-24 ± 2 h) presented good correlation with the selected independent variables. Statistical analysis (ANOVA) of the optimized bilayer formulations showed no significant difference in the cumulative amount of drug release after 15 min, but significant difference (p < 0.05) in the amount of drug released after 1 hr till 12 h from optimized formulations was observed. The natural mucilage like FNM could be successfully incorporated into tablet with only 20% replacement with HPMC and it showed good bioadhesiveness and sustained drug release.

No MeSH data available.


Related in: MedlinePlus