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Strategies of Vibrio parahaemolyticus to acquire nutritional iron during host colonization.

León-Sicairos N, Angulo-Zamudio UA, de la Garza M, Velázquez-Román J, Flores-Villaseñor HM, Canizalez-Román A - Front Microbiol (2015)

Bottom Line: In these strategies are included the use of siderophores and xenosiderophores, proteases and iron-protein receptor.The host sources used by V. parahaemolyticus are the iron-containing proteins transferrin, hemoglobin, and hemin.The implications of iron acquisition systems in the virulence of V. parahaemolyticus are also discussed.

View Article: PubMed Central - PubMed

Affiliation: Unidad de Investigación, Facultad de Medicina, Universidad Autónoma de Sinaloa Culiacán, Mexico ; Departamento de Investigación, Hospital Pediátrico de Sinaloa "Dr. Rigoberto Aguilar Pico" Culiacán, Mexico.

ABSTRACT
Iron is an essential element for the growth and development of virtually all living organisms. As iron acquisition is critical for the pathogenesis, a host defense strategy during infection is to sequester iron to restrict the growth of invading pathogens. To counteract this strategy, bacteria such as Vibrio parahaemolyticus have adapted to such an environment by developing mechanisms to obtain iron from human hosts. This review focuses on the multiple strategies employed by V. parahaemolyticus to obtain nutritional iron from host sources. In these strategies are included the use of siderophores and xenosiderophores, proteases and iron-protein receptor. The host sources used by V. parahaemolyticus are the iron-containing proteins transferrin, hemoglobin, and hemin. The implications of iron acquisition systems in the virulence of V. parahaemolyticus are also discussed.

No MeSH data available.


Related in: MedlinePlus

Iron sources available in the environmental niches of Vibrio parahaemolyticus.V. parahaemolyticus is an obligate halophilic organism, meaning that it requires salt to live. This organism is naturally occurring and found worldwide. It can commonly be found free swimming or attached to underwater surfaces and is found at high concentrations in areas of significant seafood consumption. Humans can acquire V. parahaemolyticus infection from infected seafood; once infected, established V. parahaemolyticus can acquire iron from different iron-containing proteins, such as hemoglobin (Hb) and transferrin (Tf).
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Figure 1: Iron sources available in the environmental niches of Vibrio parahaemolyticus.V. parahaemolyticus is an obligate halophilic organism, meaning that it requires salt to live. This organism is naturally occurring and found worldwide. It can commonly be found free swimming or attached to underwater surfaces and is found at high concentrations in areas of significant seafood consumption. Humans can acquire V. parahaemolyticus infection from infected seafood; once infected, established V. parahaemolyticus can acquire iron from different iron-containing proteins, such as hemoglobin (Hb) and transferrin (Tf).

Mentions: Inside the human body the solubility of iron is extremely low, because the Fe exists in insoluble mineral complexes, or under aerobic, aqueous, and neutral pH conditions, that difficult the access of bacteria to this element. Besides, Fe is bound to mammalian high-affinity iron-binding proteins such as Tf, Lf, and Ft and in consequence, many bacteria have developed high-affinity Fe transport systems to acquire Fe from sources in their niches (Rangel et al., 2008; Jin et al., 2009; Tanabe et al., 2012). The Fe sources available in the different environmental niches of V. parahaemolyticus are described and discussed in Figure 1.


Strategies of Vibrio parahaemolyticus to acquire nutritional iron during host colonization.

León-Sicairos N, Angulo-Zamudio UA, de la Garza M, Velázquez-Román J, Flores-Villaseñor HM, Canizalez-Román A - Front Microbiol (2015)

Iron sources available in the environmental niches of Vibrio parahaemolyticus.V. parahaemolyticus is an obligate halophilic organism, meaning that it requires salt to live. This organism is naturally occurring and found worldwide. It can commonly be found free swimming or attached to underwater surfaces and is found at high concentrations in areas of significant seafood consumption. Humans can acquire V. parahaemolyticus infection from infected seafood; once infected, established V. parahaemolyticus can acquire iron from different iron-containing proteins, such as hemoglobin (Hb) and transferrin (Tf).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4496571&req=5

Figure 1: Iron sources available in the environmental niches of Vibrio parahaemolyticus.V. parahaemolyticus is an obligate halophilic organism, meaning that it requires salt to live. This organism is naturally occurring and found worldwide. It can commonly be found free swimming or attached to underwater surfaces and is found at high concentrations in areas of significant seafood consumption. Humans can acquire V. parahaemolyticus infection from infected seafood; once infected, established V. parahaemolyticus can acquire iron from different iron-containing proteins, such as hemoglobin (Hb) and transferrin (Tf).
Mentions: Inside the human body the solubility of iron is extremely low, because the Fe exists in insoluble mineral complexes, or under aerobic, aqueous, and neutral pH conditions, that difficult the access of bacteria to this element. Besides, Fe is bound to mammalian high-affinity iron-binding proteins such as Tf, Lf, and Ft and in consequence, many bacteria have developed high-affinity Fe transport systems to acquire Fe from sources in their niches (Rangel et al., 2008; Jin et al., 2009; Tanabe et al., 2012). The Fe sources available in the different environmental niches of V. parahaemolyticus are described and discussed in Figure 1.

Bottom Line: In these strategies are included the use of siderophores and xenosiderophores, proteases and iron-protein receptor.The host sources used by V. parahaemolyticus are the iron-containing proteins transferrin, hemoglobin, and hemin.The implications of iron acquisition systems in the virulence of V. parahaemolyticus are also discussed.

View Article: PubMed Central - PubMed

Affiliation: Unidad de Investigación, Facultad de Medicina, Universidad Autónoma de Sinaloa Culiacán, Mexico ; Departamento de Investigación, Hospital Pediátrico de Sinaloa "Dr. Rigoberto Aguilar Pico" Culiacán, Mexico.

ABSTRACT
Iron is an essential element for the growth and development of virtually all living organisms. As iron acquisition is critical for the pathogenesis, a host defense strategy during infection is to sequester iron to restrict the growth of invading pathogens. To counteract this strategy, bacteria such as Vibrio parahaemolyticus have adapted to such an environment by developing mechanisms to obtain iron from human hosts. This review focuses on the multiple strategies employed by V. parahaemolyticus to obtain nutritional iron from host sources. In these strategies are included the use of siderophores and xenosiderophores, proteases and iron-protein receptor. The host sources used by V. parahaemolyticus are the iron-containing proteins transferrin, hemoglobin, and hemin. The implications of iron acquisition systems in the virulence of V. parahaemolyticus are also discussed.

No MeSH data available.


Related in: MedlinePlus