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Normocalcemic primary hyperparathyroidism: a survey in a small village of Southern Italy.

Vignali E, Cetani F, Chiavistelli S, Meola A, Saponaro F, Centoni R, Cianferotti L, Marcocci C - Endocr Connect (2015)

Bottom Line: Twenty subjects did not meet the inclusion criteria and 341 could not be evaluated because of thawing of plasma samples.Our data suggest, in line with previous studies, that NPHPT might be a distinct clinical entity, being either an early phenotype of asymptomatic PHPT or a distinct variant of it.However, we cannot exclude that NPHPT might also represent an early phase of non-classical SHPT, since other variables, in addition to those currently taken into account for the diagnosis of NPHPT, might cumulate in a normocalcemic subject to increase PTH secretion.

View Article: PubMed Central - PubMed

Affiliation: Endocrine Unit 2University Hospital of Pisa, Via Paradisa 2, 56124 Pisa, ItalyDepartment of Clinical and Experimental MedicineUniversity of Pisa, Pisa, ItalyLaboratory of Chemistry and EndocrinologyUniversity Hospital of Pisa, Pisa, Italy.

No MeSH data available.


Related in: MedlinePlus

Diagram of the study population and evaluation. Plasma PTH levels were normally distributed in these 100 subjects; the upper limit of the normal range of plasma PTH was set at the mean+3s.d.
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fig1: Diagram of the study population and evaluation. Plasma PTH levels were normally distributed in these 100 subjects; the upper limit of the normal range of plasma PTH was set at the mean+3s.d.

Mentions: The survey was conducted in the late summer of 2010 in Pescopagano, a village in Southern Italy, together with a study on the prevalence of thyroid disorders (8). All residents registered in 2010 (n=2045) were invited by two consecutive calls and 1046 adults participated in the study (Fig. 1). Informed consent was obtained from all participants.


Normocalcemic primary hyperparathyroidism: a survey in a small village of Southern Italy.

Vignali E, Cetani F, Chiavistelli S, Meola A, Saponaro F, Centoni R, Cianferotti L, Marcocci C - Endocr Connect (2015)

Diagram of the study population and evaluation. Plasma PTH levels were normally distributed in these 100 subjects; the upper limit of the normal range of plasma PTH was set at the mean+3s.d.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4496527&req=5

fig1: Diagram of the study population and evaluation. Plasma PTH levels were normally distributed in these 100 subjects; the upper limit of the normal range of plasma PTH was set at the mean+3s.d.
Mentions: The survey was conducted in the late summer of 2010 in Pescopagano, a village in Southern Italy, together with a study on the prevalence of thyroid disorders (8). All residents registered in 2010 (n=2045) were invited by two consecutive calls and 1046 adults participated in the study (Fig. 1). Informed consent was obtained from all participants.

Bottom Line: Twenty subjects did not meet the inclusion criteria and 341 could not be evaluated because of thawing of plasma samples.Our data suggest, in line with previous studies, that NPHPT might be a distinct clinical entity, being either an early phenotype of asymptomatic PHPT or a distinct variant of it.However, we cannot exclude that NPHPT might also represent an early phase of non-classical SHPT, since other variables, in addition to those currently taken into account for the diagnosis of NPHPT, might cumulate in a normocalcemic subject to increase PTH secretion.

View Article: PubMed Central - PubMed

Affiliation: Endocrine Unit 2University Hospital of Pisa, Via Paradisa 2, 56124 Pisa, ItalyDepartment of Clinical and Experimental MedicineUniversity of Pisa, Pisa, ItalyLaboratory of Chemistry and EndocrinologyUniversity Hospital of Pisa, Pisa, Italy.

No MeSH data available.


Related in: MedlinePlus