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Oral Administration of Escin Inhibits Acute Inflammation and Reduces Intestinal Mucosal Injury in Animal Models.

Li M, Lu C, Zhang L, Zhang J, Du Y, Duan S, Wang T, Fu F - Evid Based Complement Alternat Med (2015)

Bottom Line: The effects of escin on carrageenan-induced paw edema in a rat model of acute inflammation, cecal ligation and puncture (CLP) induced intestinal mucosal injury in a mouse model, were observed.It was shown that oral administration of escin inhibits carrageenan-induced paw edema and decreases the production of prostaglandin E2 (PGE2) and cyclooxygenase- (COX-) 2.These findings suggest that escin effectively inhibits acute inflammation and reduces intestinal mucosal injury in animal models.

View Article: PubMed Central - PubMed

Affiliation: Key Laboratory of Molecular Pharmacology and Drug Evaluation (Ministry of Education of China), School of Pharmacy, Yantai University, Yantai, Shandong 264005, China.

ABSTRACT
The present study aimed to investigate the effects of oral administration of escin on acute inflammation and intestinal mucosal injury in animal models. The effects of escin on carrageenan-induced paw edema in a rat model of acute inflammation, cecal ligation and puncture (CLP) induced intestinal mucosal injury in a mouse model, were observed. It was shown that oral administration of escin inhibits carrageenan-induced paw edema and decreases the production of prostaglandin E2 (PGE2) and cyclooxygenase- (COX-) 2. In CLP model, low dose of escin ameliorates endotoxin induced liver injury and intestinal mucosal injury and increases the expression of tight junction protein claudin-5 in mice. These findings suggest that escin effectively inhibits acute inflammation and reduces intestinal mucosal injury in animal models.

No MeSH data available.


Related in: MedlinePlus

Effects of escin after oral administration on the DAO activity and endotoxin level in CLP induced endotoxemic mice. A value of P < 0.05 was accepted as indicating a statistically significant difference among groups. △△P < 0.01, compared with the sham group; ∗P < 0.05 and ∗∗P < 0.01, compared with the CLP group.
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fig8: Effects of escin after oral administration on the DAO activity and endotoxin level in CLP induced endotoxemic mice. A value of P < 0.05 was accepted as indicating a statistically significant difference among groups. △△P < 0.01, compared with the sham group; ∗P < 0.05 and ∗∗P < 0.01, compared with the CLP group.

Mentions: DAO activity and the endotoxin level in plasma were remarkably higher in the CLP group than those in the sham control group (P < 0.01). Compared to CLP group, levels of DAO activity and endotoxin in low dose escin-treated group were remarkably lower (P < 0.01, P < 0.05) (Figure 8).


Oral Administration of Escin Inhibits Acute Inflammation and Reduces Intestinal Mucosal Injury in Animal Models.

Li M, Lu C, Zhang L, Zhang J, Du Y, Duan S, Wang T, Fu F - Evid Based Complement Alternat Med (2015)

Effects of escin after oral administration on the DAO activity and endotoxin level in CLP induced endotoxemic mice. A value of P < 0.05 was accepted as indicating a statistically significant difference among groups. △△P < 0.01, compared with the sham group; ∗P < 0.05 and ∗∗P < 0.01, compared with the CLP group.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4496496&req=5

fig8: Effects of escin after oral administration on the DAO activity and endotoxin level in CLP induced endotoxemic mice. A value of P < 0.05 was accepted as indicating a statistically significant difference among groups. △△P < 0.01, compared with the sham group; ∗P < 0.05 and ∗∗P < 0.01, compared with the CLP group.
Mentions: DAO activity and the endotoxin level in plasma were remarkably higher in the CLP group than those in the sham control group (P < 0.01). Compared to CLP group, levels of DAO activity and endotoxin in low dose escin-treated group were remarkably lower (P < 0.01, P < 0.05) (Figure 8).

Bottom Line: The effects of escin on carrageenan-induced paw edema in a rat model of acute inflammation, cecal ligation and puncture (CLP) induced intestinal mucosal injury in a mouse model, were observed.It was shown that oral administration of escin inhibits carrageenan-induced paw edema and decreases the production of prostaglandin E2 (PGE2) and cyclooxygenase- (COX-) 2.These findings suggest that escin effectively inhibits acute inflammation and reduces intestinal mucosal injury in animal models.

View Article: PubMed Central - PubMed

Affiliation: Key Laboratory of Molecular Pharmacology and Drug Evaluation (Ministry of Education of China), School of Pharmacy, Yantai University, Yantai, Shandong 264005, China.

ABSTRACT
The present study aimed to investigate the effects of oral administration of escin on acute inflammation and intestinal mucosal injury in animal models. The effects of escin on carrageenan-induced paw edema in a rat model of acute inflammation, cecal ligation and puncture (CLP) induced intestinal mucosal injury in a mouse model, were observed. It was shown that oral administration of escin inhibits carrageenan-induced paw edema and decreases the production of prostaglandin E2 (PGE2) and cyclooxygenase- (COX-) 2. In CLP model, low dose of escin ameliorates endotoxin induced liver injury and intestinal mucosal injury and increases the expression of tight junction protein claudin-5 in mice. These findings suggest that escin effectively inhibits acute inflammation and reduces intestinal mucosal injury in animal models.

No MeSH data available.


Related in: MedlinePlus