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Oral Administration of Escin Inhibits Acute Inflammation and Reduces Intestinal Mucosal Injury in Animal Models.

Li M, Lu C, Zhang L, Zhang J, Du Y, Duan S, Wang T, Fu F - Evid Based Complement Alternat Med (2015)

Bottom Line: The effects of escin on carrageenan-induced paw edema in a rat model of acute inflammation, cecal ligation and puncture (CLP) induced intestinal mucosal injury in a mouse model, were observed.It was shown that oral administration of escin inhibits carrageenan-induced paw edema and decreases the production of prostaglandin E2 (PGE2) and cyclooxygenase- (COX-) 2.These findings suggest that escin effectively inhibits acute inflammation and reduces intestinal mucosal injury in animal models.

View Article: PubMed Central - PubMed

Affiliation: Key Laboratory of Molecular Pharmacology and Drug Evaluation (Ministry of Education of China), School of Pharmacy, Yantai University, Yantai, Shandong 264005, China.

ABSTRACT
The present study aimed to investigate the effects of oral administration of escin on acute inflammation and intestinal mucosal injury in animal models. The effects of escin on carrageenan-induced paw edema in a rat model of acute inflammation, cecal ligation and puncture (CLP) induced intestinal mucosal injury in a mouse model, were observed. It was shown that oral administration of escin inhibits carrageenan-induced paw edema and decreases the production of prostaglandin E2 (PGE2) and cyclooxygenase- (COX-) 2. In CLP model, low dose of escin ameliorates endotoxin induced liver injury and intestinal mucosal injury and increases the expression of tight junction protein claudin-5 in mice. These findings suggest that escin effectively inhibits acute inflammation and reduces intestinal mucosal injury in animal models.

No MeSH data available.


Related in: MedlinePlus

Effects of escin after oral administration on intestinal pathological changes in CLP induced endotoxemic mice. Representative histological changes in intestine obtained from different groups: (a) sham group; (b) CLP group; (c) CLP + Dex group; (d) CLP + Escin 5 mg/kg group; (e) CLP + Escin 10 mg/kg group; (f) CLP + Escin 20 mg/kg group (n = 3 for each group).
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fig7: Effects of escin after oral administration on intestinal pathological changes in CLP induced endotoxemic mice. Representative histological changes in intestine obtained from different groups: (a) sham group; (b) CLP group; (c) CLP + Dex group; (d) CLP + Escin 5 mg/kg group; (e) CLP + Escin 10 mg/kg group; (f) CLP + Escin 20 mg/kg group (n = 3 for each group).

Mentions: Compared with those of the sham control mice, the H-E stained sections of intestinal tissues from mice with CLP operation showed focal and superficial lamina propria edema and increased inflammation, epithelial layers separated from both sides of villi, and a few villi exfoliated; oral administration of escin (at doses of 5 mg/kg and 10 mg/kg) significantly attenuated damage in CLP induced endotoxemic mice (Figure 7).


Oral Administration of Escin Inhibits Acute Inflammation and Reduces Intestinal Mucosal Injury in Animal Models.

Li M, Lu C, Zhang L, Zhang J, Du Y, Duan S, Wang T, Fu F - Evid Based Complement Alternat Med (2015)

Effects of escin after oral administration on intestinal pathological changes in CLP induced endotoxemic mice. Representative histological changes in intestine obtained from different groups: (a) sham group; (b) CLP group; (c) CLP + Dex group; (d) CLP + Escin 5 mg/kg group; (e) CLP + Escin 10 mg/kg group; (f) CLP + Escin 20 mg/kg group (n = 3 for each group).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4496496&req=5

fig7: Effects of escin after oral administration on intestinal pathological changes in CLP induced endotoxemic mice. Representative histological changes in intestine obtained from different groups: (a) sham group; (b) CLP group; (c) CLP + Dex group; (d) CLP + Escin 5 mg/kg group; (e) CLP + Escin 10 mg/kg group; (f) CLP + Escin 20 mg/kg group (n = 3 for each group).
Mentions: Compared with those of the sham control mice, the H-E stained sections of intestinal tissues from mice with CLP operation showed focal and superficial lamina propria edema and increased inflammation, epithelial layers separated from both sides of villi, and a few villi exfoliated; oral administration of escin (at doses of 5 mg/kg and 10 mg/kg) significantly attenuated damage in CLP induced endotoxemic mice (Figure 7).

Bottom Line: The effects of escin on carrageenan-induced paw edema in a rat model of acute inflammation, cecal ligation and puncture (CLP) induced intestinal mucosal injury in a mouse model, were observed.It was shown that oral administration of escin inhibits carrageenan-induced paw edema and decreases the production of prostaglandin E2 (PGE2) and cyclooxygenase- (COX-) 2.These findings suggest that escin effectively inhibits acute inflammation and reduces intestinal mucosal injury in animal models.

View Article: PubMed Central - PubMed

Affiliation: Key Laboratory of Molecular Pharmacology and Drug Evaluation (Ministry of Education of China), School of Pharmacy, Yantai University, Yantai, Shandong 264005, China.

ABSTRACT
The present study aimed to investigate the effects of oral administration of escin on acute inflammation and intestinal mucosal injury in animal models. The effects of escin on carrageenan-induced paw edema in a rat model of acute inflammation, cecal ligation and puncture (CLP) induced intestinal mucosal injury in a mouse model, were observed. It was shown that oral administration of escin inhibits carrageenan-induced paw edema and decreases the production of prostaglandin E2 (PGE2) and cyclooxygenase- (COX-) 2. In CLP model, low dose of escin ameliorates endotoxin induced liver injury and intestinal mucosal injury and increases the expression of tight junction protein claudin-5 in mice. These findings suggest that escin effectively inhibits acute inflammation and reduces intestinal mucosal injury in animal models.

No MeSH data available.


Related in: MedlinePlus