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Oral Administration of Escin Inhibits Acute Inflammation and Reduces Intestinal Mucosal Injury in Animal Models.

Li M, Lu C, Zhang L, Zhang J, Du Y, Duan S, Wang T, Fu F - Evid Based Complement Alternat Med (2015)

Bottom Line: The effects of escin on carrageenan-induced paw edema in a rat model of acute inflammation, cecal ligation and puncture (CLP) induced intestinal mucosal injury in a mouse model, were observed.It was shown that oral administration of escin inhibits carrageenan-induced paw edema and decreases the production of prostaglandin E2 (PGE2) and cyclooxygenase- (COX-) 2.These findings suggest that escin effectively inhibits acute inflammation and reduces intestinal mucosal injury in animal models.

View Article: PubMed Central - PubMed

Affiliation: Key Laboratory of Molecular Pharmacology and Drug Evaluation (Ministry of Education of China), School of Pharmacy, Yantai University, Yantai, Shandong 264005, China.

ABSTRACT
The present study aimed to investigate the effects of oral administration of escin on acute inflammation and intestinal mucosal injury in animal models. The effects of escin on carrageenan-induced paw edema in a rat model of acute inflammation, cecal ligation and puncture (CLP) induced intestinal mucosal injury in a mouse model, were observed. It was shown that oral administration of escin inhibits carrageenan-induced paw edema and decreases the production of prostaglandin E2 (PGE2) and cyclooxygenase- (COX-) 2. In CLP model, low dose of escin ameliorates endotoxin induced liver injury and intestinal mucosal injury and increases the expression of tight junction protein claudin-5 in mice. These findings suggest that escin effectively inhibits acute inflammation and reduces intestinal mucosal injury in animal models.

No MeSH data available.


Related in: MedlinePlus

Effects of escin after oral administration on liver histological changes in CLP induced endotoxemic mice. Representative histological changes in livers obtained from different groups: (a) sham group; (b) CLP group; (c) CLP + Dex group; (d) CLP + Escin 5 mg/kg group; (e) CLP + Escin 10 mg/kg group; (f) CLP + Escin 20 mg/kg group (n = 3 for each group, magnification, 400x; Olympus BX41, Japan).
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fig6: Effects of escin after oral administration on liver histological changes in CLP induced endotoxemic mice. Representative histological changes in livers obtained from different groups: (a) sham group; (b) CLP group; (c) CLP + Dex group; (d) CLP + Escin 5 mg/kg group; (e) CLP + Escin 10 mg/kg group; (f) CLP + Escin 20 mg/kg group (n = 3 for each group, magnification, 400x; Olympus BX41, Japan).

Mentions: Liver sections from the CLP group showed significant granulocyte infiltration, disruption of cellular morphology, obvious congestion of the hepatic sinusoids, and hepatocellular necrosis compared to the sham group. Escin after oral administration (at doses of 5 mg/kg and 10 mg/kg) significantly attenuated liver damage in CLP induced endotoxemic mice (Figure 6).


Oral Administration of Escin Inhibits Acute Inflammation and Reduces Intestinal Mucosal Injury in Animal Models.

Li M, Lu C, Zhang L, Zhang J, Du Y, Duan S, Wang T, Fu F - Evid Based Complement Alternat Med (2015)

Effects of escin after oral administration on liver histological changes in CLP induced endotoxemic mice. Representative histological changes in livers obtained from different groups: (a) sham group; (b) CLP group; (c) CLP + Dex group; (d) CLP + Escin 5 mg/kg group; (e) CLP + Escin 10 mg/kg group; (f) CLP + Escin 20 mg/kg group (n = 3 for each group, magnification, 400x; Olympus BX41, Japan).
© Copyright Policy - open-access
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC4496496&req=5

fig6: Effects of escin after oral administration on liver histological changes in CLP induced endotoxemic mice. Representative histological changes in livers obtained from different groups: (a) sham group; (b) CLP group; (c) CLP + Dex group; (d) CLP + Escin 5 mg/kg group; (e) CLP + Escin 10 mg/kg group; (f) CLP + Escin 20 mg/kg group (n = 3 for each group, magnification, 400x; Olympus BX41, Japan).
Mentions: Liver sections from the CLP group showed significant granulocyte infiltration, disruption of cellular morphology, obvious congestion of the hepatic sinusoids, and hepatocellular necrosis compared to the sham group. Escin after oral administration (at doses of 5 mg/kg and 10 mg/kg) significantly attenuated liver damage in CLP induced endotoxemic mice (Figure 6).

Bottom Line: The effects of escin on carrageenan-induced paw edema in a rat model of acute inflammation, cecal ligation and puncture (CLP) induced intestinal mucosal injury in a mouse model, were observed.It was shown that oral administration of escin inhibits carrageenan-induced paw edema and decreases the production of prostaglandin E2 (PGE2) and cyclooxygenase- (COX-) 2.These findings suggest that escin effectively inhibits acute inflammation and reduces intestinal mucosal injury in animal models.

View Article: PubMed Central - PubMed

Affiliation: Key Laboratory of Molecular Pharmacology and Drug Evaluation (Ministry of Education of China), School of Pharmacy, Yantai University, Yantai, Shandong 264005, China.

ABSTRACT
The present study aimed to investigate the effects of oral administration of escin on acute inflammation and intestinal mucosal injury in animal models. The effects of escin on carrageenan-induced paw edema in a rat model of acute inflammation, cecal ligation and puncture (CLP) induced intestinal mucosal injury in a mouse model, were observed. It was shown that oral administration of escin inhibits carrageenan-induced paw edema and decreases the production of prostaglandin E2 (PGE2) and cyclooxygenase- (COX-) 2. In CLP model, low dose of escin ameliorates endotoxin induced liver injury and intestinal mucosal injury and increases the expression of tight junction protein claudin-5 in mice. These findings suggest that escin effectively inhibits acute inflammation and reduces intestinal mucosal injury in animal models.

No MeSH data available.


Related in: MedlinePlus