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Oral Administration of Escin Inhibits Acute Inflammation and Reduces Intestinal Mucosal Injury in Animal Models.

Li M, Lu C, Zhang L, Zhang J, Du Y, Duan S, Wang T, Fu F - Evid Based Complement Alternat Med (2015)

Bottom Line: The effects of escin on carrageenan-induced paw edema in a rat model of acute inflammation, cecal ligation and puncture (CLP) induced intestinal mucosal injury in a mouse model, were observed.It was shown that oral administration of escin inhibits carrageenan-induced paw edema and decreases the production of prostaglandin E2 (PGE2) and cyclooxygenase- (COX-) 2.These findings suggest that escin effectively inhibits acute inflammation and reduces intestinal mucosal injury in animal models.

View Article: PubMed Central - PubMed

Affiliation: Key Laboratory of Molecular Pharmacology and Drug Evaluation (Ministry of Education of China), School of Pharmacy, Yantai University, Yantai, Shandong 264005, China.

ABSTRACT
The present study aimed to investigate the effects of oral administration of escin on acute inflammation and intestinal mucosal injury in animal models. The effects of escin on carrageenan-induced paw edema in a rat model of acute inflammation, cecal ligation and puncture (CLP) induced intestinal mucosal injury in a mouse model, were observed. It was shown that oral administration of escin inhibits carrageenan-induced paw edema and decreases the production of prostaglandin E2 (PGE2) and cyclooxygenase- (COX-) 2. In CLP model, low dose of escin ameliorates endotoxin induced liver injury and intestinal mucosal injury and increases the expression of tight junction protein claudin-5 in mice. These findings suggest that escin effectively inhibits acute inflammation and reduces intestinal mucosal injury in animal models.

No MeSH data available.


Related in: MedlinePlus

Effects of escin after oral administration on histological pathology of the edema paws in rats. Tissues of the right-hind paw were stained with hematoxylin and eosin (H-E). (a) Vehicle group; (b) Dex group; (c) escin (i.v., 1.8 mg/kg) group; (d) escin (p.o., 10 mg/kg) group. Arrows indicate the inflammatory cells (n = 3 for each group, magnification, 400x; Olympus BX41, Japan).
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fig3: Effects of escin after oral administration on histological pathology of the edema paws in rats. Tissues of the right-hind paw were stained with hematoxylin and eosin (H-E). (a) Vehicle group; (b) Dex group; (c) escin (i.v., 1.8 mg/kg) group; (d) escin (p.o., 10 mg/kg) group. Arrows indicate the inflammatory cells (n = 3 for each group, magnification, 400x; Olympus BX41, Japan).

Mentions: Extensively inflammatory cells in the paw tissue were observed 4 h after carrageenan injection, and the number of neutrophils increased significantly. Compared with the vehicle group, Dex (6 mg/kg), escin injection (1.8 mg/kg), and oral administration (10 mg/kg) of escin all significantly reduced the number of inflammatory cells (Figure 3).


Oral Administration of Escin Inhibits Acute Inflammation and Reduces Intestinal Mucosal Injury in Animal Models.

Li M, Lu C, Zhang L, Zhang J, Du Y, Duan S, Wang T, Fu F - Evid Based Complement Alternat Med (2015)

Effects of escin after oral administration on histological pathology of the edema paws in rats. Tissues of the right-hind paw were stained with hematoxylin and eosin (H-E). (a) Vehicle group; (b) Dex group; (c) escin (i.v., 1.8 mg/kg) group; (d) escin (p.o., 10 mg/kg) group. Arrows indicate the inflammatory cells (n = 3 for each group, magnification, 400x; Olympus BX41, Japan).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4496496&req=5

fig3: Effects of escin after oral administration on histological pathology of the edema paws in rats. Tissues of the right-hind paw were stained with hematoxylin and eosin (H-E). (a) Vehicle group; (b) Dex group; (c) escin (i.v., 1.8 mg/kg) group; (d) escin (p.o., 10 mg/kg) group. Arrows indicate the inflammatory cells (n = 3 for each group, magnification, 400x; Olympus BX41, Japan).
Mentions: Extensively inflammatory cells in the paw tissue were observed 4 h after carrageenan injection, and the number of neutrophils increased significantly. Compared with the vehicle group, Dex (6 mg/kg), escin injection (1.8 mg/kg), and oral administration (10 mg/kg) of escin all significantly reduced the number of inflammatory cells (Figure 3).

Bottom Line: The effects of escin on carrageenan-induced paw edema in a rat model of acute inflammation, cecal ligation and puncture (CLP) induced intestinal mucosal injury in a mouse model, were observed.It was shown that oral administration of escin inhibits carrageenan-induced paw edema and decreases the production of prostaglandin E2 (PGE2) and cyclooxygenase- (COX-) 2.These findings suggest that escin effectively inhibits acute inflammation and reduces intestinal mucosal injury in animal models.

View Article: PubMed Central - PubMed

Affiliation: Key Laboratory of Molecular Pharmacology and Drug Evaluation (Ministry of Education of China), School of Pharmacy, Yantai University, Yantai, Shandong 264005, China.

ABSTRACT
The present study aimed to investigate the effects of oral administration of escin on acute inflammation and intestinal mucosal injury in animal models. The effects of escin on carrageenan-induced paw edema in a rat model of acute inflammation, cecal ligation and puncture (CLP) induced intestinal mucosal injury in a mouse model, were observed. It was shown that oral administration of escin inhibits carrageenan-induced paw edema and decreases the production of prostaglandin E2 (PGE2) and cyclooxygenase- (COX-) 2. In CLP model, low dose of escin ameliorates endotoxin induced liver injury and intestinal mucosal injury and increases the expression of tight junction protein claudin-5 in mice. These findings suggest that escin effectively inhibits acute inflammation and reduces intestinal mucosal injury in animal models.

No MeSH data available.


Related in: MedlinePlus