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Oral Administration of Escin Inhibits Acute Inflammation and Reduces Intestinal Mucosal Injury in Animal Models.

Li M, Lu C, Zhang L, Zhang J, Du Y, Duan S, Wang T, Fu F - Evid Based Complement Alternat Med (2015)

Bottom Line: The effects of escin on carrageenan-induced paw edema in a rat model of acute inflammation, cecal ligation and puncture (CLP) induced intestinal mucosal injury in a mouse model, were observed.It was shown that oral administration of escin inhibits carrageenan-induced paw edema and decreases the production of prostaglandin E2 (PGE2) and cyclooxygenase- (COX-) 2.These findings suggest that escin effectively inhibits acute inflammation and reduces intestinal mucosal injury in animal models.

View Article: PubMed Central - PubMed

Affiliation: Key Laboratory of Molecular Pharmacology and Drug Evaluation (Ministry of Education of China), School of Pharmacy, Yantai University, Yantai, Shandong 264005, China.

ABSTRACT
The present study aimed to investigate the effects of oral administration of escin on acute inflammation and intestinal mucosal injury in animal models. The effects of escin on carrageenan-induced paw edema in a rat model of acute inflammation, cecal ligation and puncture (CLP) induced intestinal mucosal injury in a mouse model, were observed. It was shown that oral administration of escin inhibits carrageenan-induced paw edema and decreases the production of prostaglandin E2 (PGE2) and cyclooxygenase- (COX-) 2. In CLP model, low dose of escin ameliorates endotoxin induced liver injury and intestinal mucosal injury and increases the expression of tight junction protein claudin-5 in mice. These findings suggest that escin effectively inhibits acute inflammation and reduces intestinal mucosal injury in animal models.

No MeSH data available.


Related in: MedlinePlus

The structure of escin.
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Related In: Results  -  Collection


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fig1: The structure of escin.

Mentions: Escin is a natural mixture of triterpene saponins extracted from the seeds of Aesculus chinensis Bge. or Aesculus wilsonii Rehd., which mainly consist of A, B, C, and D escin (Figure 1). Accumulating experimental evidence in previous studies suggests that intravenous administration of escin exerts potent anti-inflammatory and antiedematous effects [6–9]. It can inhibit acetic acid induced vascular permeability in an acute inflammation mouse model and granuloma formation in a subchronic inflammatory rat model. At present, escin injection has been widely used clinically to prevent inflammatory edema after trauma such as fracture and operation in China [10, 11].


Oral Administration of Escin Inhibits Acute Inflammation and Reduces Intestinal Mucosal Injury in Animal Models.

Li M, Lu C, Zhang L, Zhang J, Du Y, Duan S, Wang T, Fu F - Evid Based Complement Alternat Med (2015)

The structure of escin.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4496496&req=5

fig1: The structure of escin.
Mentions: Escin is a natural mixture of triterpene saponins extracted from the seeds of Aesculus chinensis Bge. or Aesculus wilsonii Rehd., which mainly consist of A, B, C, and D escin (Figure 1). Accumulating experimental evidence in previous studies suggests that intravenous administration of escin exerts potent anti-inflammatory and antiedematous effects [6–9]. It can inhibit acetic acid induced vascular permeability in an acute inflammation mouse model and granuloma formation in a subchronic inflammatory rat model. At present, escin injection has been widely used clinically to prevent inflammatory edema after trauma such as fracture and operation in China [10, 11].

Bottom Line: The effects of escin on carrageenan-induced paw edema in a rat model of acute inflammation, cecal ligation and puncture (CLP) induced intestinal mucosal injury in a mouse model, were observed.It was shown that oral administration of escin inhibits carrageenan-induced paw edema and decreases the production of prostaglandin E2 (PGE2) and cyclooxygenase- (COX-) 2.These findings suggest that escin effectively inhibits acute inflammation and reduces intestinal mucosal injury in animal models.

View Article: PubMed Central - PubMed

Affiliation: Key Laboratory of Molecular Pharmacology and Drug Evaluation (Ministry of Education of China), School of Pharmacy, Yantai University, Yantai, Shandong 264005, China.

ABSTRACT
The present study aimed to investigate the effects of oral administration of escin on acute inflammation and intestinal mucosal injury in animal models. The effects of escin on carrageenan-induced paw edema in a rat model of acute inflammation, cecal ligation and puncture (CLP) induced intestinal mucosal injury in a mouse model, were observed. It was shown that oral administration of escin inhibits carrageenan-induced paw edema and decreases the production of prostaglandin E2 (PGE2) and cyclooxygenase- (COX-) 2. In CLP model, low dose of escin ameliorates endotoxin induced liver injury and intestinal mucosal injury and increases the expression of tight junction protein claudin-5 in mice. These findings suggest that escin effectively inhibits acute inflammation and reduces intestinal mucosal injury in animal models.

No MeSH data available.


Related in: MedlinePlus