Limits...
Advances and Prospects in Tissue-Engineered Meniscal Scaffolds for Meniscus Regeneration.

Guo W, Liu S, Zhu Y, Yu C, Lu S, Yuan M, Gao Y, Huang J, Yuan Z, Peng J, Wang A, Wang Y, Chen J, Zhang L, Sui X, Xu W, Guo Q - Stem Cells Int (2015)

Bottom Line: Similarly, other current therapeutic strategies have intrinsic limitations in clinical practice.Tissue engineering technology will probably address this challenge by reconstructing a meniscus possessing an integrated configuration with competent biomechanical capacity.Last, we present current advances in meniscal scaffolds and provide a number of prospects that will potentially benefit the development of meniscal regeneration methods.

View Article: PubMed Central - PubMed

Affiliation: Institute of Orthopaedics, Chinese PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing 100853, China.

ABSTRACT
The meniscus plays a crucial role in maintaining knee joint homoeostasis. Meniscal lesions are relatively common in the knee joint and are typically categorized into various types. However, it is difficult for inner avascular meniscal lesions to self-heal. Untreated meniscal lesions lead to meniscal extrusions in the long-term and gradually trigger the development of knee osteoarthritis (OA). The relationship between meniscal lesions and knee OA is complex. Partial meniscectomy, which is the primary method to treat a meniscal injury, only relieves short-term pain; however, it does not prevent the development of knee OA. Similarly, other current therapeutic strategies have intrinsic limitations in clinical practice. Tissue engineering technology will probably address this challenge by reconstructing a meniscus possessing an integrated configuration with competent biomechanical capacity. This review describes normal structure and biomechanical characteristics of the meniscus, discusses the relationship between meniscal lesions and knee OA, and summarizes the classifications and corresponding treatment strategies for meniscal lesions to understand meniscal regeneration from physiological and pathological perspectives. Last, we present current advances in meniscal scaffolds and provide a number of prospects that will potentially benefit the development of meniscal regeneration methods.

No MeSH data available.


Related in: MedlinePlus

Schematic diagram of the eight different types of meniscal lesions according to Casscells classification.
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fig5: Schematic diagram of the eight different types of meniscal lesions according to Casscells classification.

Mentions: Damage to the meniscus is very common in the knee joint. Meniscal lesions are typically categorized into distinct age groups. Meniscal injuries in younger patients (<40 years) are usually caused by trauma or congenital meniscal diseases, whereas those in older patients (>40 years) tend to be associated with degenerative tears [39]. In general, all meniscal lesions can be comprehensively classified into eight different types according to Casscells classification (Figure 5) [40]. However, meniscal injuries can simply be classified clinically into peripheral meniscal lesions and avascular meniscal lesions.


Advances and Prospects in Tissue-Engineered Meniscal Scaffolds for Meniscus Regeneration.

Guo W, Liu S, Zhu Y, Yu C, Lu S, Yuan M, Gao Y, Huang J, Yuan Z, Peng J, Wang A, Wang Y, Chen J, Zhang L, Sui X, Xu W, Guo Q - Stem Cells Int (2015)

Schematic diagram of the eight different types of meniscal lesions according to Casscells classification.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4496486&req=5

fig5: Schematic diagram of the eight different types of meniscal lesions according to Casscells classification.
Mentions: Damage to the meniscus is very common in the knee joint. Meniscal lesions are typically categorized into distinct age groups. Meniscal injuries in younger patients (<40 years) are usually caused by trauma or congenital meniscal diseases, whereas those in older patients (>40 years) tend to be associated with degenerative tears [39]. In general, all meniscal lesions can be comprehensively classified into eight different types according to Casscells classification (Figure 5) [40]. However, meniscal injuries can simply be classified clinically into peripheral meniscal lesions and avascular meniscal lesions.

Bottom Line: Similarly, other current therapeutic strategies have intrinsic limitations in clinical practice.Tissue engineering technology will probably address this challenge by reconstructing a meniscus possessing an integrated configuration with competent biomechanical capacity.Last, we present current advances in meniscal scaffolds and provide a number of prospects that will potentially benefit the development of meniscal regeneration methods.

View Article: PubMed Central - PubMed

Affiliation: Institute of Orthopaedics, Chinese PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing 100853, China.

ABSTRACT
The meniscus plays a crucial role in maintaining knee joint homoeostasis. Meniscal lesions are relatively common in the knee joint and are typically categorized into various types. However, it is difficult for inner avascular meniscal lesions to self-heal. Untreated meniscal lesions lead to meniscal extrusions in the long-term and gradually trigger the development of knee osteoarthritis (OA). The relationship between meniscal lesions and knee OA is complex. Partial meniscectomy, which is the primary method to treat a meniscal injury, only relieves short-term pain; however, it does not prevent the development of knee OA. Similarly, other current therapeutic strategies have intrinsic limitations in clinical practice. Tissue engineering technology will probably address this challenge by reconstructing a meniscus possessing an integrated configuration with competent biomechanical capacity. This review describes normal structure and biomechanical characteristics of the meniscus, discusses the relationship between meniscal lesions and knee OA, and summarizes the classifications and corresponding treatment strategies for meniscal lesions to understand meniscal regeneration from physiological and pathological perspectives. Last, we present current advances in meniscal scaffolds and provide a number of prospects that will potentially benefit the development of meniscal regeneration methods.

No MeSH data available.


Related in: MedlinePlus