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Advances and Prospects in Tissue-Engineered Meniscal Scaffolds for Meniscus Regeneration.

Guo W, Liu S, Zhu Y, Yu C, Lu S, Yuan M, Gao Y, Huang J, Yuan Z, Peng J, Wang A, Wang Y, Chen J, Zhang L, Sui X, Xu W, Guo Q - Stem Cells Int (2015)

Bottom Line: However, it is difficult for inner avascular meniscal lesions to self-heal.Similarly, other current therapeutic strategies have intrinsic limitations in clinical practice.Tissue engineering technology will probably address this challenge by reconstructing a meniscus possessing an integrated configuration with competent biomechanical capacity.

View Article: PubMed Central - PubMed

Affiliation: Institute of Orthopaedics, Chinese PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing 100853, China.

ABSTRACT
The meniscus plays a crucial role in maintaining knee joint homoeostasis. Meniscal lesions are relatively common in the knee joint and are typically categorized into various types. However, it is difficult for inner avascular meniscal lesions to self-heal. Untreated meniscal lesions lead to meniscal extrusions in the long-term and gradually trigger the development of knee osteoarthritis (OA). The relationship between meniscal lesions and knee OA is complex. Partial meniscectomy, which is the primary method to treat a meniscal injury, only relieves short-term pain; however, it does not prevent the development of knee OA. Similarly, other current therapeutic strategies have intrinsic limitations in clinical practice. Tissue engineering technology will probably address this challenge by reconstructing a meniscus possessing an integrated configuration with competent biomechanical capacity. This review describes normal structure and biomechanical characteristics of the meniscus, discusses the relationship between meniscal lesions and knee OA, and summarizes the classifications and corresponding treatment strategies for meniscal lesions to understand meniscal regeneration from physiological and pathological perspectives. Last, we present current advances in meniscal scaffolds and provide a number of prospects that will potentially benefit the development of meniscal regeneration methods.

No MeSH data available.


Related in: MedlinePlus

The interaction between meniscal injury and knee osteoarthritis (OA). Knee mechanics become abnormal when a meniscus is injured, which leads to increasing stress across adjacent cartilage and subchondral bone. This stress triggers release of inflammatory cytokines, which further impair the meniscal extracellular matrix (ECM) and accelerate the vicious cycle of knee OA. OA of the knee joint also causes release of inflammatory cytokines, repeating the vicious cycle.
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fig4: The interaction between meniscal injury and knee osteoarthritis (OA). Knee mechanics become abnormal when a meniscus is injured, which leads to increasing stress across adjacent cartilage and subchondral bone. This stress triggers release of inflammatory cytokines, which further impair the meniscal extracellular matrix (ECM) and accelerate the vicious cycle of knee OA. OA of the knee joint also causes release of inflammatory cytokines, repeating the vicious cycle.

Mentions: Meniscal lesions are closely associated with the development of knee OA, and their relationship is complex [34]. Meniscal lesions can ultimately lead to knee OA, and knee OA also induces meniscal tears; therefore, normally configured menisci are rarely observed in patients with knee OA [35, 36]. An injured meniscus triggers the synovium to release various inflammatory cytokines, which induce degenerative changes in the meniscal matrix. These degenerative changes derived from early stage tears can gradually develop into meniscal extrusions that increase the stress on tibial cartilage and further aggravate the injury [24]. In addition, inflammatory cytokines released into OA joints simultaneously act on the meniscus and cartilage, as they have similar ECM components. Therefore, knee OA induced by other diseases is harmful to the meniscus and triggers similar pathological changes [25, 26, 37, 38]. Hence, a natural vicious cycle forms between meniscal lesions and the development of knee OA (Figure 4).


Advances and Prospects in Tissue-Engineered Meniscal Scaffolds for Meniscus Regeneration.

Guo W, Liu S, Zhu Y, Yu C, Lu S, Yuan M, Gao Y, Huang J, Yuan Z, Peng J, Wang A, Wang Y, Chen J, Zhang L, Sui X, Xu W, Guo Q - Stem Cells Int (2015)

The interaction between meniscal injury and knee osteoarthritis (OA). Knee mechanics become abnormal when a meniscus is injured, which leads to increasing stress across adjacent cartilage and subchondral bone. This stress triggers release of inflammatory cytokines, which further impair the meniscal extracellular matrix (ECM) and accelerate the vicious cycle of knee OA. OA of the knee joint also causes release of inflammatory cytokines, repeating the vicious cycle.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4496486&req=5

fig4: The interaction between meniscal injury and knee osteoarthritis (OA). Knee mechanics become abnormal when a meniscus is injured, which leads to increasing stress across adjacent cartilage and subchondral bone. This stress triggers release of inflammatory cytokines, which further impair the meniscal extracellular matrix (ECM) and accelerate the vicious cycle of knee OA. OA of the knee joint also causes release of inflammatory cytokines, repeating the vicious cycle.
Mentions: Meniscal lesions are closely associated with the development of knee OA, and their relationship is complex [34]. Meniscal lesions can ultimately lead to knee OA, and knee OA also induces meniscal tears; therefore, normally configured menisci are rarely observed in patients with knee OA [35, 36]. An injured meniscus triggers the synovium to release various inflammatory cytokines, which induce degenerative changes in the meniscal matrix. These degenerative changes derived from early stage tears can gradually develop into meniscal extrusions that increase the stress on tibial cartilage and further aggravate the injury [24]. In addition, inflammatory cytokines released into OA joints simultaneously act on the meniscus and cartilage, as they have similar ECM components. Therefore, knee OA induced by other diseases is harmful to the meniscus and triggers similar pathological changes [25, 26, 37, 38]. Hence, a natural vicious cycle forms between meniscal lesions and the development of knee OA (Figure 4).

Bottom Line: However, it is difficult for inner avascular meniscal lesions to self-heal.Similarly, other current therapeutic strategies have intrinsic limitations in clinical practice.Tissue engineering technology will probably address this challenge by reconstructing a meniscus possessing an integrated configuration with competent biomechanical capacity.

View Article: PubMed Central - PubMed

Affiliation: Institute of Orthopaedics, Chinese PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing 100853, China.

ABSTRACT
The meniscus plays a crucial role in maintaining knee joint homoeostasis. Meniscal lesions are relatively common in the knee joint and are typically categorized into various types. However, it is difficult for inner avascular meniscal lesions to self-heal. Untreated meniscal lesions lead to meniscal extrusions in the long-term and gradually trigger the development of knee osteoarthritis (OA). The relationship between meniscal lesions and knee OA is complex. Partial meniscectomy, which is the primary method to treat a meniscal injury, only relieves short-term pain; however, it does not prevent the development of knee OA. Similarly, other current therapeutic strategies have intrinsic limitations in clinical practice. Tissue engineering technology will probably address this challenge by reconstructing a meniscus possessing an integrated configuration with competent biomechanical capacity. This review describes normal structure and biomechanical characteristics of the meniscus, discusses the relationship between meniscal lesions and knee OA, and summarizes the classifications and corresponding treatment strategies for meniscal lesions to understand meniscal regeneration from physiological and pathological perspectives. Last, we present current advances in meniscal scaffolds and provide a number of prospects that will potentially benefit the development of meniscal regeneration methods.

No MeSH data available.


Related in: MedlinePlus