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Advances and Prospects in Tissue-Engineered Meniscal Scaffolds for Meniscus Regeneration.

Guo W, Liu S, Zhu Y, Yu C, Lu S, Yuan M, Gao Y, Huang J, Yuan Z, Peng J, Wang A, Wang Y, Chen J, Zhang L, Sui X, Xu W, Guo Q - Stem Cells Int (2015)

Bottom Line: Similarly, other current therapeutic strategies have intrinsic limitations in clinical practice.Tissue engineering technology will probably address this challenge by reconstructing a meniscus possessing an integrated configuration with competent biomechanical capacity.Last, we present current advances in meniscal scaffolds and provide a number of prospects that will potentially benefit the development of meniscal regeneration methods.

View Article: PubMed Central - PubMed

Affiliation: Institute of Orthopaedics, Chinese PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing 100853, China.

ABSTRACT
The meniscus plays a crucial role in maintaining knee joint homoeostasis. Meniscal lesions are relatively common in the knee joint and are typically categorized into various types. However, it is difficult for inner avascular meniscal lesions to self-heal. Untreated meniscal lesions lead to meniscal extrusions in the long-term and gradually trigger the development of knee osteoarthritis (OA). The relationship between meniscal lesions and knee OA is complex. Partial meniscectomy, which is the primary method to treat a meniscal injury, only relieves short-term pain; however, it does not prevent the development of knee OA. Similarly, other current therapeutic strategies have intrinsic limitations in clinical practice. Tissue engineering technology will probably address this challenge by reconstructing a meniscus possessing an integrated configuration with competent biomechanical capacity. This review describes normal structure and biomechanical characteristics of the meniscus, discusses the relationship between meniscal lesions and knee OA, and summarizes the classifications and corresponding treatment strategies for meniscal lesions to understand meniscal regeneration from physiological and pathological perspectives. Last, we present current advances in meniscal scaffolds and provide a number of prospects that will potentially benefit the development of meniscal regeneration methods.

No MeSH data available.


Related in: MedlinePlus

Schematic diagram of the meniscus force-bearing mechanism. Meniscal configuration adapts well to the corresponding shape of the femoral condyles and the tibial plateau in the knee joint. The axial load force (F) perpendicular to the meniscus surface and horizontal force (fr) are created by compressing the femur (Ff). F rebounds due to the tibial upgrade force (Ft), whereas the fr leads to meniscal extrusion radially, which is countered by the pulling force from the anterior and posterior insertional ligaments. Consequently, tensile hoop stress is created along the circumferential directions during axial compression.
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fig3: Schematic diagram of the meniscus force-bearing mechanism. Meniscal configuration adapts well to the corresponding shape of the femoral condyles and the tibial plateau in the knee joint. The axial load force (F) perpendicular to the meniscus surface and horizontal force (fr) are created by compressing the femur (Ff). F rebounds due to the tibial upgrade force (Ft), whereas the fr leads to meniscal extrusion radially, which is countered by the pulling force from the anterior and posterior insertional ligaments. Consequently, tensile hoop stress is created along the circumferential directions during axial compression.

Mentions: The anatomic geometry of the meniscus is closely associated with its biomechanical properties. The meniscal configuration adapts to the corresponding shapes of the femoral condyles and tibial plateau, which provide a considerable increase in contact area in the knee joint [29, 30]. Tensile hoop stress is created around the circumference when the knee bears an axial load, and this stress tries to extrude the meniscus out of the knee joint (Figure 3). However, firm attachment at the anterior and posterior insertional ligaments helps prevent extrusion of the meniscus [31, 32]. Thus, intact menisci occupy the corresponding contact area (60%) between the femoral condyles and the tibial plateau cartilage, which significantly reduces stress and protects the tibial cartilage. In contrast, if the anterior or posterior insertional ligaments or peripheral circumferential collagen fibers rupture [33], the load transmission mechanism changes, which damages the tibial cartilage.


Advances and Prospects in Tissue-Engineered Meniscal Scaffolds for Meniscus Regeneration.

Guo W, Liu S, Zhu Y, Yu C, Lu S, Yuan M, Gao Y, Huang J, Yuan Z, Peng J, Wang A, Wang Y, Chen J, Zhang L, Sui X, Xu W, Guo Q - Stem Cells Int (2015)

Schematic diagram of the meniscus force-bearing mechanism. Meniscal configuration adapts well to the corresponding shape of the femoral condyles and the tibial plateau in the knee joint. The axial load force (F) perpendicular to the meniscus surface and horizontal force (fr) are created by compressing the femur (Ff). F rebounds due to the tibial upgrade force (Ft), whereas the fr leads to meniscal extrusion radially, which is countered by the pulling force from the anterior and posterior insertional ligaments. Consequently, tensile hoop stress is created along the circumferential directions during axial compression.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4496486&req=5

fig3: Schematic diagram of the meniscus force-bearing mechanism. Meniscal configuration adapts well to the corresponding shape of the femoral condyles and the tibial plateau in the knee joint. The axial load force (F) perpendicular to the meniscus surface and horizontal force (fr) are created by compressing the femur (Ff). F rebounds due to the tibial upgrade force (Ft), whereas the fr leads to meniscal extrusion radially, which is countered by the pulling force from the anterior and posterior insertional ligaments. Consequently, tensile hoop stress is created along the circumferential directions during axial compression.
Mentions: The anatomic geometry of the meniscus is closely associated with its biomechanical properties. The meniscal configuration adapts to the corresponding shapes of the femoral condyles and tibial plateau, which provide a considerable increase in contact area in the knee joint [29, 30]. Tensile hoop stress is created around the circumference when the knee bears an axial load, and this stress tries to extrude the meniscus out of the knee joint (Figure 3). However, firm attachment at the anterior and posterior insertional ligaments helps prevent extrusion of the meniscus [31, 32]. Thus, intact menisci occupy the corresponding contact area (60%) between the femoral condyles and the tibial plateau cartilage, which significantly reduces stress and protects the tibial cartilage. In contrast, if the anterior or posterior insertional ligaments or peripheral circumferential collagen fibers rupture [33], the load transmission mechanism changes, which damages the tibial cartilage.

Bottom Line: Similarly, other current therapeutic strategies have intrinsic limitations in clinical practice.Tissue engineering technology will probably address this challenge by reconstructing a meniscus possessing an integrated configuration with competent biomechanical capacity.Last, we present current advances in meniscal scaffolds and provide a number of prospects that will potentially benefit the development of meniscal regeneration methods.

View Article: PubMed Central - PubMed

Affiliation: Institute of Orthopaedics, Chinese PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing 100853, China.

ABSTRACT
The meniscus plays a crucial role in maintaining knee joint homoeostasis. Meniscal lesions are relatively common in the knee joint and are typically categorized into various types. However, it is difficult for inner avascular meniscal lesions to self-heal. Untreated meniscal lesions lead to meniscal extrusions in the long-term and gradually trigger the development of knee osteoarthritis (OA). The relationship between meniscal lesions and knee OA is complex. Partial meniscectomy, which is the primary method to treat a meniscal injury, only relieves short-term pain; however, it does not prevent the development of knee OA. Similarly, other current therapeutic strategies have intrinsic limitations in clinical practice. Tissue engineering technology will probably address this challenge by reconstructing a meniscus possessing an integrated configuration with competent biomechanical capacity. This review describes normal structure and biomechanical characteristics of the meniscus, discusses the relationship between meniscal lesions and knee OA, and summarizes the classifications and corresponding treatment strategies for meniscal lesions to understand meniscal regeneration from physiological and pathological perspectives. Last, we present current advances in meniscal scaffolds and provide a number of prospects that will potentially benefit the development of meniscal regeneration methods.

No MeSH data available.


Related in: MedlinePlus