Limits...
Advances and Prospects in Tissue-Engineered Meniscal Scaffolds for Meniscus Regeneration.

Guo W, Liu S, Zhu Y, Yu C, Lu S, Yuan M, Gao Y, Huang J, Yuan Z, Peng J, Wang A, Wang Y, Chen J, Zhang L, Sui X, Xu W, Guo Q - Stem Cells Int (2015)

Bottom Line: Similarly, other current therapeutic strategies have intrinsic limitations in clinical practice.Tissue engineering technology will probably address this challenge by reconstructing a meniscus possessing an integrated configuration with competent biomechanical capacity.Last, we present current advances in meniscal scaffolds and provide a number of prospects that will potentially benefit the development of meniscal regeneration methods.

View Article: PubMed Central - PubMed

Affiliation: Institute of Orthopaedics, Chinese PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing 100853, China.

ABSTRACT
The meniscus plays a crucial role in maintaining knee joint homoeostasis. Meniscal lesions are relatively common in the knee joint and are typically categorized into various types. However, it is difficult for inner avascular meniscal lesions to self-heal. Untreated meniscal lesions lead to meniscal extrusions in the long-term and gradually trigger the development of knee osteoarthritis (OA). The relationship between meniscal lesions and knee OA is complex. Partial meniscectomy, which is the primary method to treat a meniscal injury, only relieves short-term pain; however, it does not prevent the development of knee OA. Similarly, other current therapeutic strategies have intrinsic limitations in clinical practice. Tissue engineering technology will probably address this challenge by reconstructing a meniscus possessing an integrated configuration with competent biomechanical capacity. This review describes normal structure and biomechanical characteristics of the meniscus, discusses the relationship between meniscal lesions and knee OA, and summarizes the classifications and corresponding treatment strategies for meniscal lesions to understand meniscal regeneration from physiological and pathological perspectives. Last, we present current advances in meniscal scaffolds and provide a number of prospects that will potentially benefit the development of meniscal regeneration methods.

No MeSH data available.


Related in: MedlinePlus

The complex composition of the meniscal cellular and meniscal extracellular matrix (ECM) components. The outer region is the outer one-third of the meniscus; the inner region is the inner two-thirds of the meniscus; the superficial region is the surface of the meniscus.
© Copyright Policy - open-access
Related In: Results  -  Collection


getmorefigures.php?uid=PMC4496486&req=5

fig2: The complex composition of the meniscal cellular and meniscal extracellular matrix (ECM) components. The outer region is the outer one-third of the meniscus; the inner region is the inner two-thirds of the meniscus; the superficial region is the surface of the meniscus.

Mentions: The meniscus has a highly heterogeneous extracellular matrix (ECM) and cell distribution [24–26]. Meniscal ECM components are more complex than those of articular cartilage. Cartilage has a homogeneous ECM composition, mainly comprised of water (70–80%), collagen (50–75%), and glycosaminoglycans (GAGs) (15–30%) [27]. The distribution of the meniscal ECM is categorized by region. Collagen type I accounts for >80% of the composition in the red-red region by dry weight, and the remaining content comprises < 1%, including collagen types II, III, IV, VI, and XVIII [14]. Total collagen content is 70% of the dry weight in the white-white region, whereas collagen types II and I account for 60% and 40%, respectively. The specific distribution of meniscal ECM components is shown in Figure 2.


Advances and Prospects in Tissue-Engineered Meniscal Scaffolds for Meniscus Regeneration.

Guo W, Liu S, Zhu Y, Yu C, Lu S, Yuan M, Gao Y, Huang J, Yuan Z, Peng J, Wang A, Wang Y, Chen J, Zhang L, Sui X, Xu W, Guo Q - Stem Cells Int (2015)

The complex composition of the meniscal cellular and meniscal extracellular matrix (ECM) components. The outer region is the outer one-third of the meniscus; the inner region is the inner two-thirds of the meniscus; the superficial region is the surface of the meniscus.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4496486&req=5

fig2: The complex composition of the meniscal cellular and meniscal extracellular matrix (ECM) components. The outer region is the outer one-third of the meniscus; the inner region is the inner two-thirds of the meniscus; the superficial region is the surface of the meniscus.
Mentions: The meniscus has a highly heterogeneous extracellular matrix (ECM) and cell distribution [24–26]. Meniscal ECM components are more complex than those of articular cartilage. Cartilage has a homogeneous ECM composition, mainly comprised of water (70–80%), collagen (50–75%), and glycosaminoglycans (GAGs) (15–30%) [27]. The distribution of the meniscal ECM is categorized by region. Collagen type I accounts for >80% of the composition in the red-red region by dry weight, and the remaining content comprises < 1%, including collagen types II, III, IV, VI, and XVIII [14]. Total collagen content is 70% of the dry weight in the white-white region, whereas collagen types II and I account for 60% and 40%, respectively. The specific distribution of meniscal ECM components is shown in Figure 2.

Bottom Line: Similarly, other current therapeutic strategies have intrinsic limitations in clinical practice.Tissue engineering technology will probably address this challenge by reconstructing a meniscus possessing an integrated configuration with competent biomechanical capacity.Last, we present current advances in meniscal scaffolds and provide a number of prospects that will potentially benefit the development of meniscal regeneration methods.

View Article: PubMed Central - PubMed

Affiliation: Institute of Orthopaedics, Chinese PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing 100853, China.

ABSTRACT
The meniscus plays a crucial role in maintaining knee joint homoeostasis. Meniscal lesions are relatively common in the knee joint and are typically categorized into various types. However, it is difficult for inner avascular meniscal lesions to self-heal. Untreated meniscal lesions lead to meniscal extrusions in the long-term and gradually trigger the development of knee osteoarthritis (OA). The relationship between meniscal lesions and knee OA is complex. Partial meniscectomy, which is the primary method to treat a meniscal injury, only relieves short-term pain; however, it does not prevent the development of knee OA. Similarly, other current therapeutic strategies have intrinsic limitations in clinical practice. Tissue engineering technology will probably address this challenge by reconstructing a meniscus possessing an integrated configuration with competent biomechanical capacity. This review describes normal structure and biomechanical characteristics of the meniscus, discusses the relationship between meniscal lesions and knee OA, and summarizes the classifications and corresponding treatment strategies for meniscal lesions to understand meniscal regeneration from physiological and pathological perspectives. Last, we present current advances in meniscal scaffolds and provide a number of prospects that will potentially benefit the development of meniscal regeneration methods.

No MeSH data available.


Related in: MedlinePlus