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The Complex Role of STAT3 in Viral Infections.

Kuchipudi SV - J Immunol Res (2015)

Bottom Line: Several studies reported differential regulation of STAT3 in a range of viral infections.Interestingly, STAT3 appears to direct seemingly contradictory responses and both pro- and antiviral roles of STAT3 have been described.Some of the key unanswered questions and the gap in our current understanding of the role of STAT3 in viral pathogenesis are discussed.

View Article: PubMed Central - PubMed

Affiliation: School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington LE12 5RD, UK.

ABSTRACT
Signal transducer and activators of transcription-3 (STAT3) regulates diverse biological functions including cell growth, differentiation, and apoptosis. In addition, STAT3 plays a key role in regulating host immune and inflammatory responses and in the pathogenesis of many cancers. Several studies reported differential regulation of STAT3 in a range of viral infections. Interestingly, STAT3 appears to direct seemingly contradictory responses and both pro- and antiviral roles of STAT3 have been described. This review summarized the currently known functions of STAT3 in the regulation of viral replication and pathogenesis of viral infections. Some of the key unanswered questions and the gap in our current understanding of the role of STAT3 in viral pathogenesis are discussed.

No MeSH data available.


Related in: MedlinePlus

STAT3 signal transduction pathway. In response to cytokines and growth factors, STAT3 is phosphorylated by receptor-associated kinases and then forms homo- or heterodimers. STAT3 dimers then translocate to the nucleus where they act as a transcription activator and mediate the expression of a variety of genes. STAT3 activates the transcription of suppressors of cytokine signalling 3 (SOCS3) which act as classical feedback inhibitor of STAT3 activation.
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fig2: STAT3 signal transduction pathway. In response to cytokines and growth factors, STAT3 is phosphorylated by receptor-associated kinases and then forms homo- or heterodimers. STAT3 dimers then translocate to the nucleus where they act as a transcription activator and mediate the expression of a variety of genes. STAT3 activates the transcription of suppressors of cytokine signalling 3 (SOCS3) which act as classical feedback inhibitor of STAT3 activation.

Mentions: The phosphorylation of STAT3 promotes homodimerization, wherein the SH2 domain of each STAT3 monomer interacts with the Y705 residue on another monomeric STAT3 [2]. STAT3 homodimers translocate into the nucleus which is mediated by importin α5/NPI-1 [44] and bind to specific DNA response elements such as the IFN-stimulated response element (ISRE) in the promoter regions of responsive target genes and regulate their transcription [45–47] (Figure 2).


The Complex Role of STAT3 in Viral Infections.

Kuchipudi SV - J Immunol Res (2015)

STAT3 signal transduction pathway. In response to cytokines and growth factors, STAT3 is phosphorylated by receptor-associated kinases and then forms homo- or heterodimers. STAT3 dimers then translocate to the nucleus where they act as a transcription activator and mediate the expression of a variety of genes. STAT3 activates the transcription of suppressors of cytokine signalling 3 (SOCS3) which act as classical feedback inhibitor of STAT3 activation.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4496485&req=5

fig2: STAT3 signal transduction pathway. In response to cytokines and growth factors, STAT3 is phosphorylated by receptor-associated kinases and then forms homo- or heterodimers. STAT3 dimers then translocate to the nucleus where they act as a transcription activator and mediate the expression of a variety of genes. STAT3 activates the transcription of suppressors of cytokine signalling 3 (SOCS3) which act as classical feedback inhibitor of STAT3 activation.
Mentions: The phosphorylation of STAT3 promotes homodimerization, wherein the SH2 domain of each STAT3 monomer interacts with the Y705 residue on another monomeric STAT3 [2]. STAT3 homodimers translocate into the nucleus which is mediated by importin α5/NPI-1 [44] and bind to specific DNA response elements such as the IFN-stimulated response element (ISRE) in the promoter regions of responsive target genes and regulate their transcription [45–47] (Figure 2).

Bottom Line: Several studies reported differential regulation of STAT3 in a range of viral infections.Interestingly, STAT3 appears to direct seemingly contradictory responses and both pro- and antiviral roles of STAT3 have been described.Some of the key unanswered questions and the gap in our current understanding of the role of STAT3 in viral pathogenesis are discussed.

View Article: PubMed Central - PubMed

Affiliation: School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington LE12 5RD, UK.

ABSTRACT
Signal transducer and activators of transcription-3 (STAT3) regulates diverse biological functions including cell growth, differentiation, and apoptosis. In addition, STAT3 plays a key role in regulating host immune and inflammatory responses and in the pathogenesis of many cancers. Several studies reported differential regulation of STAT3 in a range of viral infections. Interestingly, STAT3 appears to direct seemingly contradictory responses and both pro- and antiviral roles of STAT3 have been described. This review summarized the currently known functions of STAT3 in the regulation of viral replication and pathogenesis of viral infections. Some of the key unanswered questions and the gap in our current understanding of the role of STAT3 in viral pathogenesis are discussed.

No MeSH data available.


Related in: MedlinePlus