Limits...
The Complex Role of STAT3 in Viral Infections.

Kuchipudi SV - J Immunol Res (2015)

Bottom Line: Several studies reported differential regulation of STAT3 in a range of viral infections.Interestingly, STAT3 appears to direct seemingly contradictory responses and both pro- and antiviral roles of STAT3 have been described.Some of the key unanswered questions and the gap in our current understanding of the role of STAT3 in viral pathogenesis are discussed.

View Article: PubMed Central - PubMed

Affiliation: School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington LE12 5RD, UK.

ABSTRACT
Signal transducer and activators of transcription-3 (STAT3) regulates diverse biological functions including cell growth, differentiation, and apoptosis. In addition, STAT3 plays a key role in regulating host immune and inflammatory responses and in the pathogenesis of many cancers. Several studies reported differential regulation of STAT3 in a range of viral infections. Interestingly, STAT3 appears to direct seemingly contradictory responses and both pro- and antiviral roles of STAT3 have been described. This review summarized the currently known functions of STAT3 in the regulation of viral replication and pathogenesis of viral infections. Some of the key unanswered questions and the gap in our current understanding of the role of STAT3 in viral pathogenesis are discussed.

No MeSH data available.


Related in: MedlinePlus

Structure of STAT3. The six domains of STAT3 are N-terminal domain (ND), coiled-coil domain (CCD), DNA-binding domain (DBD), linker domain, SH2 domain, and transcriptional activation domain (TAD). Between SH2 and TAD there is a tail segment that contains the phosphorylation site Y705.
© Copyright Policy - open-access
Related In: Results  -  Collection


getmorefigures.php?uid=PMC4496485&req=5

fig1: Structure of STAT3. The six domains of STAT3 are N-terminal domain (ND), coiled-coil domain (CCD), DNA-binding domain (DBD), linker domain, SH2 domain, and transcriptional activation domain (TAD). Between SH2 and TAD there is a tail segment that contains the phosphorylation site Y705.

Mentions: The structure of STAT3 is similar to the other STAT family members comprising six structural regions, namely, N-terminal domain (ND), coiled-coil domain (CCD), DNA-binding domain (DBD), linker domain, SH2 domain, and a C-terminal transcriptional activation domain (TAD) (Figure 1). The core fragment of STAT3 comprising CCD, DBD, linker, and SH2 domains is monomeric and the dimer interface observed in the unphosphorylated STAT1 core fragment structure is absent in the STAT3 structure [22].


The Complex Role of STAT3 in Viral Infections.

Kuchipudi SV - J Immunol Res (2015)

Structure of STAT3. The six domains of STAT3 are N-terminal domain (ND), coiled-coil domain (CCD), DNA-binding domain (DBD), linker domain, SH2 domain, and transcriptional activation domain (TAD). Between SH2 and TAD there is a tail segment that contains the phosphorylation site Y705.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4496485&req=5

fig1: Structure of STAT3. The six domains of STAT3 are N-terminal domain (ND), coiled-coil domain (CCD), DNA-binding domain (DBD), linker domain, SH2 domain, and transcriptional activation domain (TAD). Between SH2 and TAD there is a tail segment that contains the phosphorylation site Y705.
Mentions: The structure of STAT3 is similar to the other STAT family members comprising six structural regions, namely, N-terminal domain (ND), coiled-coil domain (CCD), DNA-binding domain (DBD), linker domain, SH2 domain, and a C-terminal transcriptional activation domain (TAD) (Figure 1). The core fragment of STAT3 comprising CCD, DBD, linker, and SH2 domains is monomeric and the dimer interface observed in the unphosphorylated STAT1 core fragment structure is absent in the STAT3 structure [22].

Bottom Line: Several studies reported differential regulation of STAT3 in a range of viral infections.Interestingly, STAT3 appears to direct seemingly contradictory responses and both pro- and antiviral roles of STAT3 have been described.Some of the key unanswered questions and the gap in our current understanding of the role of STAT3 in viral pathogenesis are discussed.

View Article: PubMed Central - PubMed

Affiliation: School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington LE12 5RD, UK.

ABSTRACT
Signal transducer and activators of transcription-3 (STAT3) regulates diverse biological functions including cell growth, differentiation, and apoptosis. In addition, STAT3 plays a key role in regulating host immune and inflammatory responses and in the pathogenesis of many cancers. Several studies reported differential regulation of STAT3 in a range of viral infections. Interestingly, STAT3 appears to direct seemingly contradictory responses and both pro- and antiviral roles of STAT3 have been described. This review summarized the currently known functions of STAT3 in the regulation of viral replication and pathogenesis of viral infections. Some of the key unanswered questions and the gap in our current understanding of the role of STAT3 in viral pathogenesis are discussed.

No MeSH data available.


Related in: MedlinePlus