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Occult Breast Lobular Carcinoma with Numerous Circulating Tumor Cells in Peripheral Blood.

Ogura K, Amano M, Matsumoto T, Sakaguchi A, Kosaka T, Kitabatake T, Kojima K - Case Rep Pathol (2015)

Bottom Line: We experienced a very rare case of occult breast lobular carcinoma with numerous circulating tumor cells in peripheral blood.The diagnosis was very difficult because there were no symptoms of breast cancer and the preceding chief complaints such as general fatigue and weight loss or abnormality of peripheral blood findings were suggestive of a hematological disease.We could make a correct diagnosis of this case by checking the findings of complete blood count and bone marrow biopsy at the same time using immunohistochemistry.

View Article: PubMed Central - PubMed

Affiliation: Department of Diagnostic Pathology, Juntendo University Nerima Hospital, Tokyo 177-8521, Japan.

ABSTRACT
We experienced a very rare case of occult breast lobular carcinoma with numerous circulating tumor cells in peripheral blood. The diagnosis was very difficult because there were no symptoms of breast cancer and the preceding chief complaints such as general fatigue and weight loss or abnormality of peripheral blood findings were suggestive of a hematological disease. We could make a correct diagnosis of this case by checking the findings of complete blood count and bone marrow biopsy at the same time using immunohistochemistry.

No MeSH data available.


Related in: MedlinePlus

Tumor cells in peripheral blood smear. Noncohesive round tumor cells resembling lymphocytes were identified.
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fig1: Tumor cells in peripheral blood smear. Noncohesive round tumor cells resembling lymphocytes were identified.

Mentions: The patient was a 65-year-old woman, with chief complaints of general fatigue and weight loss. The findings of peripheral blood test are summarized in Table 1. The number of leukocytes was high (22,200/μL) and atypical unclassified cells were identified in her peripheral blood count. Those cells were counted as “other” at a level of 7.5%. The atypical cells were noncohesive and had round nuclei and cytoplasm with microvilli resembling lymphocytes or plasma cells in form (Figure 1). The serum calcium level was high (13.4 mg/dL). Such findings leaded her physician into the suspicion of hematological disease such as lymphoma or myeloma although the serum level of CEA was also high (621 ng/mL).


Occult Breast Lobular Carcinoma with Numerous Circulating Tumor Cells in Peripheral Blood.

Ogura K, Amano M, Matsumoto T, Sakaguchi A, Kosaka T, Kitabatake T, Kojima K - Case Rep Pathol (2015)

Tumor cells in peripheral blood smear. Noncohesive round tumor cells resembling lymphocytes were identified.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4496473&req=5

fig1: Tumor cells in peripheral blood smear. Noncohesive round tumor cells resembling lymphocytes were identified.
Mentions: The patient was a 65-year-old woman, with chief complaints of general fatigue and weight loss. The findings of peripheral blood test are summarized in Table 1. The number of leukocytes was high (22,200/μL) and atypical unclassified cells were identified in her peripheral blood count. Those cells were counted as “other” at a level of 7.5%. The atypical cells were noncohesive and had round nuclei and cytoplasm with microvilli resembling lymphocytes or plasma cells in form (Figure 1). The serum calcium level was high (13.4 mg/dL). Such findings leaded her physician into the suspicion of hematological disease such as lymphoma or myeloma although the serum level of CEA was also high (621 ng/mL).

Bottom Line: We experienced a very rare case of occult breast lobular carcinoma with numerous circulating tumor cells in peripheral blood.The diagnosis was very difficult because there were no symptoms of breast cancer and the preceding chief complaints such as general fatigue and weight loss or abnormality of peripheral blood findings were suggestive of a hematological disease.We could make a correct diagnosis of this case by checking the findings of complete blood count and bone marrow biopsy at the same time using immunohistochemistry.

View Article: PubMed Central - PubMed

Affiliation: Department of Diagnostic Pathology, Juntendo University Nerima Hospital, Tokyo 177-8521, Japan.

ABSTRACT
We experienced a very rare case of occult breast lobular carcinoma with numerous circulating tumor cells in peripheral blood. The diagnosis was very difficult because there were no symptoms of breast cancer and the preceding chief complaints such as general fatigue and weight loss or abnormality of peripheral blood findings were suggestive of a hematological disease. We could make a correct diagnosis of this case by checking the findings of complete blood count and bone marrow biopsy at the same time using immunohistochemistry.

No MeSH data available.


Related in: MedlinePlus