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A Surgically Resected Large Sarcomatoid Carcinoma of the Jejunum: A Case Report and Literature Review.

Lee HM, Cho MS, Kim YI - J Gastric Cancer (2015)

Bottom Line: Both lobes of the liver had multiple metastases.On immunohistochemical analysis, the tumor was positive for epithelial and mesenchymal markers.The patient died from rapid progression of the liver metastases 6 weeks after the surgery.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Ewha Womans University School of Medicine, Seoul, Korea.

ABSTRACT
Sarcomatoid carcinoma of the small intestine is rare, and only 30 cases have been reported to date. This disease generally exhibits a very poor prognosis. Here we report the case of a 67-year-old man with a sarcomatoid carcinoma in the jejunum, who was hospitalized for diarrhea, fever, nausea, and vomiting. The tumor was located at the jejunum and had a large round shape with geographic necrosis. It involved the entire wall of the small intestine and had directly invaded the neighboring sigmoid colon. Both lobes of the liver had multiple metastases. The patient underwent surgical resection of the jejunum. On immunohistochemical analysis, the tumor was positive for epithelial and mesenchymal markers. The patient died from rapid progression of the liver metastases 6 weeks after the surgery.

No MeSH data available.


Related in: MedlinePlus

The tumor cells were negative for DOG-1 on immunohistochemistry (×400).
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Figure 4: The tumor cells were negative for DOG-1 on immunohistochemistry (×400).

Mentions: Immunohistochemical staining revealed a diffuse and strong positive reaction for vimentin, a positive reaction for Pan-CK (Fig. 3), and a focal positive reaction for c-kit (CD117). By contrast, CK20, CDX2, CD3, CD30, CEA, desmin, myoD1, and S-100 all appeared to be negative. A negative reaction was noted for DOG-1 (Fig. 4), which is usually positive in GISTs. The pathological test results were indicative of SCA of the jejunum.


A Surgically Resected Large Sarcomatoid Carcinoma of the Jejunum: A Case Report and Literature Review.

Lee HM, Cho MS, Kim YI - J Gastric Cancer (2015)

The tumor cells were negative for DOG-1 on immunohistochemistry (×400).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4496442&req=5

Figure 4: The tumor cells were negative for DOG-1 on immunohistochemistry (×400).
Mentions: Immunohistochemical staining revealed a diffuse and strong positive reaction for vimentin, a positive reaction for Pan-CK (Fig. 3), and a focal positive reaction for c-kit (CD117). By contrast, CK20, CDX2, CD3, CD30, CEA, desmin, myoD1, and S-100 all appeared to be negative. A negative reaction was noted for DOG-1 (Fig. 4), which is usually positive in GISTs. The pathological test results were indicative of SCA of the jejunum.

Bottom Line: Both lobes of the liver had multiple metastases.On immunohistochemical analysis, the tumor was positive for epithelial and mesenchymal markers.The patient died from rapid progression of the liver metastases 6 weeks after the surgery.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Ewha Womans University School of Medicine, Seoul, Korea.

ABSTRACT
Sarcomatoid carcinoma of the small intestine is rare, and only 30 cases have been reported to date. This disease generally exhibits a very poor prognosis. Here we report the case of a 67-year-old man with a sarcomatoid carcinoma in the jejunum, who was hospitalized for diarrhea, fever, nausea, and vomiting. The tumor was located at the jejunum and had a large round shape with geographic necrosis. It involved the entire wall of the small intestine and had directly invaded the neighboring sigmoid colon. Both lobes of the liver had multiple metastases. The patient underwent surgical resection of the jejunum. On immunohistochemical analysis, the tumor was positive for epithelial and mesenchymal markers. The patient died from rapid progression of the liver metastases 6 weeks after the surgery.

No MeSH data available.


Related in: MedlinePlus