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Factors influencing serum progesterone level on triggering day in stimulated in vitro fertilization cycles.

Park JH, Jee BC, Kim SH - Clin Exp Reprod Med (2015)

Bottom Line: The woman's age, body mass index, antral follicle count, and basal serum follicle stimulating hormone and estradiol levels were not associated with serum P level on triggering day.The serum P level on triggering day did not show significant variation depending on the type or cause of infertility, pituitary suppression protocol, or the type of gonadotropins used.The serum P level on triggering day was closely related to the response to ovarian stimulation.

View Article: PubMed Central - PubMed

Affiliation: M Fertility Center, Seoul, Korea.

ABSTRACT

Objective: Elevated serum progesterone (P) levels on triggering day have been known to affect the pregnancy rate of in vitro fertilization (IVF). This study aimed to identify the possible factors influencing serum P levels on triggering day in stimulated IVF cycles.

Methods: Three hundred and thirty consecutive fresh IVF cycles were included in the study. All cycles were first attempts and were performed in a single infertility center. The indications for IVF were male factor infertility (n=114), ovulatory infertility (n=84), endometriosis (n=61), tubal infertility (n=59), unexplained infertility (n=41), and uterine factor infertility (n=39). A luteal long protocol of a gonadotropin-releasing hormone (GnRH) agonist (n=184) or a GnRH antagonist protocol (n=146) was used for pituitary suppression. Ovarian sensitivity was defined as the serum estradiol level on triggering day per 500 IU of administered gonadotropins (OS[a]) or the retrieved oocyte number per 500 IU of administered gonadotropins (OS[b]).

Results: Univariate analysis revealed that the serum P level on triggering day was associated with the serum estradiol level on triggering day (r=0.379, p<0.001), the number of follicles ≥14 mm (r=0.247, p<0.001), the number of retrieved oocytes (r=0.384, p<0.001), and ovarian sensitivity (OS[a]: r=0.245, p<0.001; OS[b]: r=0.170, p=0.002). The woman's age, body mass index, antral follicle count, and basal serum follicle stimulating hormone and estradiol levels were not associated with serum P level on triggering day. The serum P level on triggering day did not show significant variation depending on the type or cause of infertility, pituitary suppression protocol, or the type of gonadotropins used.

Conclusion: The serum P level on triggering day was closely related to the response to ovarian stimulation.

No MeSH data available.


Related in: MedlinePlus

Histogram of serum progesterone levels on triggering day. The mean serum progesterone level was 0.56 ng/mL (standard deviation [SD], 0.45 ng/mL; range, 0.1-4.4 ng/mL).
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Figure 1: Histogram of serum progesterone levels on triggering day. The mean serum progesterone level was 0.56 ng/mL (standard deviation [SD], 0.45 ng/mL; range, 0.1-4.4 ng/mL).

Mentions: The distribution of serum P levels on triggering day is depicted in Figure 1. The mean serum P level was 0.56 ng/mL (standard deviation, 0.45 ng/mL; range, 0.1-4.4 ng/mL). A serum P level on triggering day ≥1.5 ng/mL (considered an elevated serum P level according to the standard criteria) was observed in 4.2% of the population of the study (14/330).


Factors influencing serum progesterone level on triggering day in stimulated in vitro fertilization cycles.

Park JH, Jee BC, Kim SH - Clin Exp Reprod Med (2015)

Histogram of serum progesterone levels on triggering day. The mean serum progesterone level was 0.56 ng/mL (standard deviation [SD], 0.45 ng/mL; range, 0.1-4.4 ng/mL).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4496434&req=5

Figure 1: Histogram of serum progesterone levels on triggering day. The mean serum progesterone level was 0.56 ng/mL (standard deviation [SD], 0.45 ng/mL; range, 0.1-4.4 ng/mL).
Mentions: The distribution of serum P levels on triggering day is depicted in Figure 1. The mean serum P level was 0.56 ng/mL (standard deviation, 0.45 ng/mL; range, 0.1-4.4 ng/mL). A serum P level on triggering day ≥1.5 ng/mL (considered an elevated serum P level according to the standard criteria) was observed in 4.2% of the population of the study (14/330).

Bottom Line: The woman's age, body mass index, antral follicle count, and basal serum follicle stimulating hormone and estradiol levels were not associated with serum P level on triggering day.The serum P level on triggering day did not show significant variation depending on the type or cause of infertility, pituitary suppression protocol, or the type of gonadotropins used.The serum P level on triggering day was closely related to the response to ovarian stimulation.

View Article: PubMed Central - PubMed

Affiliation: M Fertility Center, Seoul, Korea.

ABSTRACT

Objective: Elevated serum progesterone (P) levels on triggering day have been known to affect the pregnancy rate of in vitro fertilization (IVF). This study aimed to identify the possible factors influencing serum P levels on triggering day in stimulated IVF cycles.

Methods: Three hundred and thirty consecutive fresh IVF cycles were included in the study. All cycles were first attempts and were performed in a single infertility center. The indications for IVF were male factor infertility (n=114), ovulatory infertility (n=84), endometriosis (n=61), tubal infertility (n=59), unexplained infertility (n=41), and uterine factor infertility (n=39). A luteal long protocol of a gonadotropin-releasing hormone (GnRH) agonist (n=184) or a GnRH antagonist protocol (n=146) was used for pituitary suppression. Ovarian sensitivity was defined as the serum estradiol level on triggering day per 500 IU of administered gonadotropins (OS[a]) or the retrieved oocyte number per 500 IU of administered gonadotropins (OS[b]).

Results: Univariate analysis revealed that the serum P level on triggering day was associated with the serum estradiol level on triggering day (r=0.379, p<0.001), the number of follicles ≥14 mm (r=0.247, p<0.001), the number of retrieved oocytes (r=0.384, p<0.001), and ovarian sensitivity (OS[a]: r=0.245, p<0.001; OS[b]: r=0.170, p=0.002). The woman's age, body mass index, antral follicle count, and basal serum follicle stimulating hormone and estradiol levels were not associated with serum P level on triggering day. The serum P level on triggering day did not show significant variation depending on the type or cause of infertility, pituitary suppression protocol, or the type of gonadotropins used.

Conclusion: The serum P level on triggering day was closely related to the response to ovarian stimulation.

No MeSH data available.


Related in: MedlinePlus