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Neurofunctional Signature of Hyperfamiliarity for Unknown Faces.

Negro E, D'Agata F, Caroppo P, Coriasco M, Ferrio F, Celeghin A, Diano M, Rubino E, de Gelder B, Rainero I, Pinessi L, Tamietto M - PLoS ONE (2015)

Bottom Line: In one such patient we investigated with a multimodal neuroimaging design the hitherto undescribed neural signature associated with hyperfamiliarity feelings.At the neural level, while morphometric analysis and single-photon emission CT (SPECT) showed the atrophy and hypofunctioning of the left temporal regions, functional magnetic resonance imaging (fMRI) revealed that hyperfamiliarity feelings were selectively associated to enhanced activity in the right medial and inferior temporal cortices.We therefore characterize the neurofunctional signature of hyperfamiliarity for unknown faces as related to the loss of coordinated activity between the complementary face processing functions of the left and right temporal lobes.

View Article: PubMed Central - PubMed

Affiliation: Department of Neuroscience, University of Torino, Torino, Italy.

ABSTRACT
Hyperfamiliarity for unknown faces is a rare selective disorder that consists of the disturbing and abnormal feeling of familiarity for unknown faces, while recognition of known faces is normal. In one such patient we investigated with a multimodal neuroimaging design the hitherto undescribed neural signature associated with hyperfamiliarity feelings. Behaviorally, signal detection methods revealed that the patient's discrimination sensitivity between familiar and unfamiliar faces was significantly lower than that of matched controls, and her response criterion for familiarity decisions was significantly more liberal. At the neural level, while morphometric analysis and single-photon emission CT (SPECT) showed the atrophy and hypofunctioning of the left temporal regions, functional magnetic resonance imaging (fMRI) revealed that hyperfamiliarity feelings were selectively associated to enhanced activity in the right medial and inferior temporal cortices. We therefore characterize the neurofunctional signature of hyperfamiliarity for unknown faces as related to the loss of coordinated activity between the complementary face processing functions of the left and right temporal lobes.

No MeSH data available.


Related in: MedlinePlus

Sulcal Depth Values and Signal Detection Response Parameters.(A) Sulcal depth values for the lateral sulcus, STS and the anterior part of the ITS in the left (LH) and right hemisphere (RH) of patient GN and of the twelve age-, gender, and education-matched controls. (B) Signal detection parameters in patient GN (red lines) and averaged parameters in the twelve controls (black lines). High discrimination sensitivity between familiar and unfamiliar faces (da) is graphically represented by reduced overlapping between signal distributions (familiarity) (continuous lines) and noise distributions (unfamiliarity) (dashed lines). Response bias (ca) is represented by the vertical lines, with negative values indicating a loose response criterion (i.e., a tendency to favour familiarity responses).
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pone.0129970.g004: Sulcal Depth Values and Signal Detection Response Parameters.(A) Sulcal depth values for the lateral sulcus, STS and the anterior part of the ITS in the left (LH) and right hemisphere (RH) of patient GN and of the twelve age-, gender, and education-matched controls. (B) Signal detection parameters in patient GN (red lines) and averaged parameters in the twelve controls (black lines). High discrimination sensitivity between familiar and unfamiliar faces (da) is graphically represented by reduced overlapping between signal distributions (familiarity) (continuous lines) and noise distributions (unfamiliarity) (dashed lines). Response bias (ca) is represented by the vertical lines, with negative values indicating a loose response criterion (i.e., a tendency to favour familiarity responses).

Mentions: Morphometric quantification with sulcal depth analysis found that the posterior segment of the lateral sulcus, the superior temporal sulcus (STS) and the anterior part of the inferior temporal sulcus (ITS) in the left hemisphere of GN were significantly deeper and wider than the corresponding sulci of the twelve age-, gender-, and education-matched controls (t11 ≥ 2.025, p ≤ 0.034 one-tailed), whereas there was no significant difference for the other sulci in either hemispheres (t11 ≤ 0.521, p ≥ 0.3) (Figs 3 and 4A).


Neurofunctional Signature of Hyperfamiliarity for Unknown Faces.

Negro E, D'Agata F, Caroppo P, Coriasco M, Ferrio F, Celeghin A, Diano M, Rubino E, de Gelder B, Rainero I, Pinessi L, Tamietto M - PLoS ONE (2015)

Sulcal Depth Values and Signal Detection Response Parameters.(A) Sulcal depth values for the lateral sulcus, STS and the anterior part of the ITS in the left (LH) and right hemisphere (RH) of patient GN and of the twelve age-, gender, and education-matched controls. (B) Signal detection parameters in patient GN (red lines) and averaged parameters in the twelve controls (black lines). High discrimination sensitivity between familiar and unfamiliar faces (da) is graphically represented by reduced overlapping between signal distributions (familiarity) (continuous lines) and noise distributions (unfamiliarity) (dashed lines). Response bias (ca) is represented by the vertical lines, with negative values indicating a loose response criterion (i.e., a tendency to favour familiarity responses).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4495981&req=5

pone.0129970.g004: Sulcal Depth Values and Signal Detection Response Parameters.(A) Sulcal depth values for the lateral sulcus, STS and the anterior part of the ITS in the left (LH) and right hemisphere (RH) of patient GN and of the twelve age-, gender, and education-matched controls. (B) Signal detection parameters in patient GN (red lines) and averaged parameters in the twelve controls (black lines). High discrimination sensitivity between familiar and unfamiliar faces (da) is graphically represented by reduced overlapping between signal distributions (familiarity) (continuous lines) and noise distributions (unfamiliarity) (dashed lines). Response bias (ca) is represented by the vertical lines, with negative values indicating a loose response criterion (i.e., a tendency to favour familiarity responses).
Mentions: Morphometric quantification with sulcal depth analysis found that the posterior segment of the lateral sulcus, the superior temporal sulcus (STS) and the anterior part of the inferior temporal sulcus (ITS) in the left hemisphere of GN were significantly deeper and wider than the corresponding sulci of the twelve age-, gender-, and education-matched controls (t11 ≥ 2.025, p ≤ 0.034 one-tailed), whereas there was no significant difference for the other sulci in either hemispheres (t11 ≤ 0.521, p ≥ 0.3) (Figs 3 and 4A).

Bottom Line: In one such patient we investigated with a multimodal neuroimaging design the hitherto undescribed neural signature associated with hyperfamiliarity feelings.At the neural level, while morphometric analysis and single-photon emission CT (SPECT) showed the atrophy and hypofunctioning of the left temporal regions, functional magnetic resonance imaging (fMRI) revealed that hyperfamiliarity feelings were selectively associated to enhanced activity in the right medial and inferior temporal cortices.We therefore characterize the neurofunctional signature of hyperfamiliarity for unknown faces as related to the loss of coordinated activity between the complementary face processing functions of the left and right temporal lobes.

View Article: PubMed Central - PubMed

Affiliation: Department of Neuroscience, University of Torino, Torino, Italy.

ABSTRACT
Hyperfamiliarity for unknown faces is a rare selective disorder that consists of the disturbing and abnormal feeling of familiarity for unknown faces, while recognition of known faces is normal. In one such patient we investigated with a multimodal neuroimaging design the hitherto undescribed neural signature associated with hyperfamiliarity feelings. Behaviorally, signal detection methods revealed that the patient's discrimination sensitivity between familiar and unfamiliar faces was significantly lower than that of matched controls, and her response criterion for familiarity decisions was significantly more liberal. At the neural level, while morphometric analysis and single-photon emission CT (SPECT) showed the atrophy and hypofunctioning of the left temporal regions, functional magnetic resonance imaging (fMRI) revealed that hyperfamiliarity feelings were selectively associated to enhanced activity in the right medial and inferior temporal cortices. We therefore characterize the neurofunctional signature of hyperfamiliarity for unknown faces as related to the loss of coordinated activity between the complementary face processing functions of the left and right temporal lobes.

No MeSH data available.


Related in: MedlinePlus