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Neurofunctional Signature of Hyperfamiliarity for Unknown Faces.

Negro E, D'Agata F, Caroppo P, Coriasco M, Ferrio F, Celeghin A, Diano M, Rubino E, de Gelder B, Rainero I, Pinessi L, Tamietto M - PLoS ONE (2015)

Bottom Line: In one such patient we investigated with a multimodal neuroimaging design the hitherto undescribed neural signature associated with hyperfamiliarity feelings.At the neural level, while morphometric analysis and single-photon emission CT (SPECT) showed the atrophy and hypofunctioning of the left temporal regions, functional magnetic resonance imaging (fMRI) revealed that hyperfamiliarity feelings were selectively associated to enhanced activity in the right medial and inferior temporal cortices.We therefore characterize the neurofunctional signature of hyperfamiliarity for unknown faces as related to the loss of coordinated activity between the complementary face processing functions of the left and right temporal lobes.

View Article: PubMed Central - PubMed

Affiliation: Department of Neuroscience, University of Torino, Torino, Italy.

ABSTRACT
Hyperfamiliarity for unknown faces is a rare selective disorder that consists of the disturbing and abnormal feeling of familiarity for unknown faces, while recognition of known faces is normal. In one such patient we investigated with a multimodal neuroimaging design the hitherto undescribed neural signature associated with hyperfamiliarity feelings. Behaviorally, signal detection methods revealed that the patient's discrimination sensitivity between familiar and unfamiliar faces was significantly lower than that of matched controls, and her response criterion for familiarity decisions was significantly more liberal. At the neural level, while morphometric analysis and single-photon emission CT (SPECT) showed the atrophy and hypofunctioning of the left temporal regions, functional magnetic resonance imaging (fMRI) revealed that hyperfamiliarity feelings were selectively associated to enhanced activity in the right medial and inferior temporal cortices. We therefore characterize the neurofunctional signature of hyperfamiliarity for unknown faces as related to the loss of coordinated activity between the complementary face processing functions of the left and right temporal lobes.

No MeSH data available.


Related in: MedlinePlus

Anatomical MRI and SPECT of Patient’s GN Brain.(A) T1-weighted MRI transversal and coronal images showing atrophy in the left temporal lobe (white circles). (B) SPECT transversal and coronal images showing hypoperfusion in the left tempo-parietal region (white circles).
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pone.0129970.g002: Anatomical MRI and SPECT of Patient’s GN Brain.(A) T1-weighted MRI transversal and coronal images showing atrophy in the left temporal lobe (white circles). (B) SPECT transversal and coronal images showing hypoperfusion in the left tempo-parietal region (white circles).

Mentions: A structural T1-weighted MRI showed left temporal lobe atrophy with deepening and widening of the temporal sulci (Fig 2A). Consistent with the anatomical findings, a 99mTc CERETEC single-photon emission CT (SPECT) scan showed a decreased uptake in the left temporo-parietal region indicative of hypoperfusion (Fig 2B).


Neurofunctional Signature of Hyperfamiliarity for Unknown Faces.

Negro E, D'Agata F, Caroppo P, Coriasco M, Ferrio F, Celeghin A, Diano M, Rubino E, de Gelder B, Rainero I, Pinessi L, Tamietto M - PLoS ONE (2015)

Anatomical MRI and SPECT of Patient’s GN Brain.(A) T1-weighted MRI transversal and coronal images showing atrophy in the left temporal lobe (white circles). (B) SPECT transversal and coronal images showing hypoperfusion in the left tempo-parietal region (white circles).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4495981&req=5

pone.0129970.g002: Anatomical MRI and SPECT of Patient’s GN Brain.(A) T1-weighted MRI transversal and coronal images showing atrophy in the left temporal lobe (white circles). (B) SPECT transversal and coronal images showing hypoperfusion in the left tempo-parietal region (white circles).
Mentions: A structural T1-weighted MRI showed left temporal lobe atrophy with deepening and widening of the temporal sulci (Fig 2A). Consistent with the anatomical findings, a 99mTc CERETEC single-photon emission CT (SPECT) scan showed a decreased uptake in the left temporo-parietal region indicative of hypoperfusion (Fig 2B).

Bottom Line: In one such patient we investigated with a multimodal neuroimaging design the hitherto undescribed neural signature associated with hyperfamiliarity feelings.At the neural level, while morphometric analysis and single-photon emission CT (SPECT) showed the atrophy and hypofunctioning of the left temporal regions, functional magnetic resonance imaging (fMRI) revealed that hyperfamiliarity feelings were selectively associated to enhanced activity in the right medial and inferior temporal cortices.We therefore characterize the neurofunctional signature of hyperfamiliarity for unknown faces as related to the loss of coordinated activity between the complementary face processing functions of the left and right temporal lobes.

View Article: PubMed Central - PubMed

Affiliation: Department of Neuroscience, University of Torino, Torino, Italy.

ABSTRACT
Hyperfamiliarity for unknown faces is a rare selective disorder that consists of the disturbing and abnormal feeling of familiarity for unknown faces, while recognition of known faces is normal. In one such patient we investigated with a multimodal neuroimaging design the hitherto undescribed neural signature associated with hyperfamiliarity feelings. Behaviorally, signal detection methods revealed that the patient's discrimination sensitivity between familiar and unfamiliar faces was significantly lower than that of matched controls, and her response criterion for familiarity decisions was significantly more liberal. At the neural level, while morphometric analysis and single-photon emission CT (SPECT) showed the atrophy and hypofunctioning of the left temporal regions, functional magnetic resonance imaging (fMRI) revealed that hyperfamiliarity feelings were selectively associated to enhanced activity in the right medial and inferior temporal cortices. We therefore characterize the neurofunctional signature of hyperfamiliarity for unknown faces as related to the loss of coordinated activity between the complementary face processing functions of the left and right temporal lobes.

No MeSH data available.


Related in: MedlinePlus