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Outbreak of febrile illness caused by coxsackievirus A4 in a nursery school in Beijing, China.

Li JS, Dong XG, Qin M, Xie ZP, Gao HC, Yang JY, Yang XX, Li DD, Li J, Duan ZJ - Virol. J. (2015)

Bottom Line: CV-A4, an etiological agent of hand, foot, and mouth disease, affects children worldwide and can circulate in closed environments such as schools and hospitals for long periods.An outbreak of febrile illness at a nursery school in Beijing, China, was confirmed to be caused by CV-A4.This outbreak was controlled by effective measures.

View Article: PubMed Central - PubMed

Affiliation: National Institute for Viral Disease Control and Prevention, China CDC, 100 Ying-Xin St., Xuan-Wu District, Beijing, 100052, China. lionalex@126.com.

ABSTRACT

Background: Coxsackievirus A4 (CV-A4) is classified as human enterovirus A according to its serotype. CV-A4, an etiological agent of hand, foot, and mouth disease, affects children worldwide and can circulate in closed environments such as schools and hospitals for long periods.

Findings: An outbreak of febrile illness at a nursery school in Beijing, China, was confirmed to be caused by CV-A4. Phylogenetic analysis of the complete genome of the isolated strain showed that the virus belongs to the same cluster as the predominant CV-A4 strain in China. This outbreak was controlled by effective measures.

Conclusions: The early identification of the pathogen and timely intervention may be the most critical factors in controlling an outbreak caused by CV-A4 in a preschool.

No MeSH data available.


Related in: MedlinePlus

Epidemiological data for the febrile illness outbreak caused by CV-A4. Graph showing the number of cases and their clinical symptoms. The trend line for the average number of cases indicates that the outbreak began on 24 May, peaked on 30 May (after intervention), and ended on 10 June
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Fig1: Epidemiological data for the febrile illness outbreak caused by CV-A4. Graph showing the number of cases and their clinical symptoms. The trend line for the average number of cases indicates that the outbreak began on 24 May, peaked on 30 May (after intervention), and ended on 10 June

Mentions: The most common symptoms in the affected children were fever (100 %; range, 37.9–41.0 °C) and pharyngeal inflammation or sore throat (21/23, 91.3 %). One boy had a cough and three had runny noses. No other symptoms were noted in any of the subjects. The mean duration of fever was 2.70 days (95 % confidence interval, 2.34–3.05). In seven cases, the peak body temperature was > 38.9 °C. Leukocytosis (white blood cell count > 15 × 109/L) was noted in four cases (Table 1). The peak incidence was between 27 May and 1 June, accounting for 78.3 % (18/23) of cases (Fig. 1).Table 1


Outbreak of febrile illness caused by coxsackievirus A4 in a nursery school in Beijing, China.

Li JS, Dong XG, Qin M, Xie ZP, Gao HC, Yang JY, Yang XX, Li DD, Li J, Duan ZJ - Virol. J. (2015)

Epidemiological data for the febrile illness outbreak caused by CV-A4. Graph showing the number of cases and their clinical symptoms. The trend line for the average number of cases indicates that the outbreak began on 24 May, peaked on 30 May (after intervention), and ended on 10 June
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4495935&req=5

Fig1: Epidemiological data for the febrile illness outbreak caused by CV-A4. Graph showing the number of cases and their clinical symptoms. The trend line for the average number of cases indicates that the outbreak began on 24 May, peaked on 30 May (after intervention), and ended on 10 June
Mentions: The most common symptoms in the affected children were fever (100 %; range, 37.9–41.0 °C) and pharyngeal inflammation or sore throat (21/23, 91.3 %). One boy had a cough and three had runny noses. No other symptoms were noted in any of the subjects. The mean duration of fever was 2.70 days (95 % confidence interval, 2.34–3.05). In seven cases, the peak body temperature was > 38.9 °C. Leukocytosis (white blood cell count > 15 × 109/L) was noted in four cases (Table 1). The peak incidence was between 27 May and 1 June, accounting for 78.3 % (18/23) of cases (Fig. 1).Table 1

Bottom Line: CV-A4, an etiological agent of hand, foot, and mouth disease, affects children worldwide and can circulate in closed environments such as schools and hospitals for long periods.An outbreak of febrile illness at a nursery school in Beijing, China, was confirmed to be caused by CV-A4.This outbreak was controlled by effective measures.

View Article: PubMed Central - PubMed

Affiliation: National Institute for Viral Disease Control and Prevention, China CDC, 100 Ying-Xin St., Xuan-Wu District, Beijing, 100052, China. lionalex@126.com.

ABSTRACT

Background: Coxsackievirus A4 (CV-A4) is classified as human enterovirus A according to its serotype. CV-A4, an etiological agent of hand, foot, and mouth disease, affects children worldwide and can circulate in closed environments such as schools and hospitals for long periods.

Findings: An outbreak of febrile illness at a nursery school in Beijing, China, was confirmed to be caused by CV-A4. Phylogenetic analysis of the complete genome of the isolated strain showed that the virus belongs to the same cluster as the predominant CV-A4 strain in China. This outbreak was controlled by effective measures.

Conclusions: The early identification of the pathogen and timely intervention may be the most critical factors in controlling an outbreak caused by CV-A4 in a preschool.

No MeSH data available.


Related in: MedlinePlus