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Serological profile of foot-and-mouth disease in wildlife populations of West and Central Africa with special reference to Syncerus caffer subspecies.

Di Nardo A, Libeau G, Chardonnet B, Chardonnet P, Kock RA, Parekh K, Hamblin P, Li Y, Parida S, Sumption KJ - Vet. Res. (2015)

Bottom Line: Different levels of exposure to the FMDV resulted for each of the buffalo subspecies sampled (p = 0.031): 68.4%, 50.0% and 0% for Nile Buffalo, West African Buffalo and African Forest Buffalo, respectively.The characterisation of the FMDV serotypes tested for buffalo found presence of antibodies against all the six FMDV serotypes tested, although high estimates for type O and SAT 3 were reported for Central Africa.The results confirmed that FMDV circulates in wild ruminants populating both West and Central Africa rangelands and in particular in buffalo, also suggesting that multiple FMDV serotypes might be involved with type O, SAT 2 and SAT 1 being dominant.

View Article: PubMed Central - PubMed

Affiliation: Institute of Biodiversity, Animal Health and Comparative Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom. a.di-nardo.1@research.gla.ac.uk.

ABSTRACT
The role which West and Central African wildlife populations might play in the transmission dynamics of FMD is not known nor have studies been performed in order to assess the distribution and prevalence of FMD in wild animal species inhabiting those specific regions of Africa. This study reports the FMD serological profile extracted from samples (n = 696) collected from wildlife of West and Central Africa between 1999 and 2003. An overall prevalence of FMDV NSP reactive sera of 31.0% (216/696) was estimated, where a significant difference in seropositivity (p = 0.000) was reported for buffalo (64.8%) as opposed to other wild animal species tested (17.8%). Different levels of exposure to the FMDV resulted for each of the buffalo subspecies sampled (p = 0.031): 68.4%, 50.0% and 0% for Nile Buffalo, West African Buffalo and African Forest Buffalo, respectively. The characterisation of the FMDV serotypes tested for buffalo found presence of antibodies against all the six FMDV serotypes tested, although high estimates for type O and SAT 3 were reported for Central Africa. Different patterns of reaction to the six FMDV serotypes tested were recorded, from sera only positive for a single serotype to multiple reactivities. The results confirmed that FMDV circulates in wild ruminants populating both West and Central Africa rangelands and in particular in buffalo, also suggesting that multiple FMDV serotypes might be involved with type O, SAT 2 and SAT 1 being dominant. Differences in serotype and spill-over risk between wildlife and livestock likely reflect regional geography, historical circulation and differing trade and livestock systems.

No MeSH data available.


Related in: MedlinePlus

Histogram and kernel density plots of the NS ELISA percentage of inhibition values estimated for the complete dataset (A) and for buffalo only (B). Red dash-dot line sets the cut-off point (PI = 50).
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Fig2: Histogram and kernel density plots of the NS ELISA percentage of inhibition values estimated for the complete dataset (A) and for buffalo only (B). Red dash-dot line sets the cut-off point (PI = 50).

Mentions: The distributions of PI values resulted from the NS ELISA test for all the wildlife species (A) and for the buffalo samples only (B) are plotted in Figure 2. The 50th percentile for all species was reported as 34.2 PI (95%CI 32.0 – 36.3), different from the buffalo distribution that returned a value of 62.0 PI (95%CI 55.1 – 66.8). This figure would reflect a defined distinction between the seronegative (mainly non-buffalo species) and the seropositive (mainly buffalo) populations, confirmed by the bimodal distribution found for all species and the left-skewed distribution for the buffalo only. In addition, a total of 39 out of 89 (43.8%) positive samples for the non-buffalo species were found having a PI value of ≥70 in contrast with the 61.4% (78/127) estimated for the buffalo population. Thirteen out of 19 samples (68.4%) tested positive for cattle, confirming potential previous exposure of domestic livestock to the FMD; 84.6% (11/13) of those were returning PI values of ≥70.Figure 2


Serological profile of foot-and-mouth disease in wildlife populations of West and Central Africa with special reference to Syncerus caffer subspecies.

Di Nardo A, Libeau G, Chardonnet B, Chardonnet P, Kock RA, Parekh K, Hamblin P, Li Y, Parida S, Sumption KJ - Vet. Res. (2015)

Histogram and kernel density plots of the NS ELISA percentage of inhibition values estimated for the complete dataset (A) and for buffalo only (B). Red dash-dot line sets the cut-off point (PI = 50).
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4495843&req=5

Fig2: Histogram and kernel density plots of the NS ELISA percentage of inhibition values estimated for the complete dataset (A) and for buffalo only (B). Red dash-dot line sets the cut-off point (PI = 50).
Mentions: The distributions of PI values resulted from the NS ELISA test for all the wildlife species (A) and for the buffalo samples only (B) are plotted in Figure 2. The 50th percentile for all species was reported as 34.2 PI (95%CI 32.0 – 36.3), different from the buffalo distribution that returned a value of 62.0 PI (95%CI 55.1 – 66.8). This figure would reflect a defined distinction between the seronegative (mainly non-buffalo species) and the seropositive (mainly buffalo) populations, confirmed by the bimodal distribution found for all species and the left-skewed distribution for the buffalo only. In addition, a total of 39 out of 89 (43.8%) positive samples for the non-buffalo species were found having a PI value of ≥70 in contrast with the 61.4% (78/127) estimated for the buffalo population. Thirteen out of 19 samples (68.4%) tested positive for cattle, confirming potential previous exposure of domestic livestock to the FMD; 84.6% (11/13) of those were returning PI values of ≥70.Figure 2

Bottom Line: Different levels of exposure to the FMDV resulted for each of the buffalo subspecies sampled (p = 0.031): 68.4%, 50.0% and 0% for Nile Buffalo, West African Buffalo and African Forest Buffalo, respectively.The characterisation of the FMDV serotypes tested for buffalo found presence of antibodies against all the six FMDV serotypes tested, although high estimates for type O and SAT 3 were reported for Central Africa.The results confirmed that FMDV circulates in wild ruminants populating both West and Central Africa rangelands and in particular in buffalo, also suggesting that multiple FMDV serotypes might be involved with type O, SAT 2 and SAT 1 being dominant.

View Article: PubMed Central - PubMed

Affiliation: Institute of Biodiversity, Animal Health and Comparative Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom. a.di-nardo.1@research.gla.ac.uk.

ABSTRACT
The role which West and Central African wildlife populations might play in the transmission dynamics of FMD is not known nor have studies been performed in order to assess the distribution and prevalence of FMD in wild animal species inhabiting those specific regions of Africa. This study reports the FMD serological profile extracted from samples (n = 696) collected from wildlife of West and Central Africa between 1999 and 2003. An overall prevalence of FMDV NSP reactive sera of 31.0% (216/696) was estimated, where a significant difference in seropositivity (p = 0.000) was reported for buffalo (64.8%) as opposed to other wild animal species tested (17.8%). Different levels of exposure to the FMDV resulted for each of the buffalo subspecies sampled (p = 0.031): 68.4%, 50.0% and 0% for Nile Buffalo, West African Buffalo and African Forest Buffalo, respectively. The characterisation of the FMDV serotypes tested for buffalo found presence of antibodies against all the six FMDV serotypes tested, although high estimates for type O and SAT 3 were reported for Central Africa. Different patterns of reaction to the six FMDV serotypes tested were recorded, from sera only positive for a single serotype to multiple reactivities. The results confirmed that FMDV circulates in wild ruminants populating both West and Central Africa rangelands and in particular in buffalo, also suggesting that multiple FMDV serotypes might be involved with type O, SAT 2 and SAT 1 being dominant. Differences in serotype and spill-over risk between wildlife and livestock likely reflect regional geography, historical circulation and differing trade and livestock systems.

No MeSH data available.


Related in: MedlinePlus