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Carbon nanotubes and graphene as emerging candidates in neuroregeneration and neurodrug delivery.

John AA, Subramanian AP, Vellayappan MV, Balaji A, Mohandas H, Jaganathan SK - Int J Nanomedicine (2015)

Bottom Line: In addition, nanomedical advances are leading to therapies that disrupt disarranged protein aggregation in the central nervous system, deliver functional neuroprotective growth factors, and change the oxidative stress and excitotoxicity of affected neural tissues to regenerate the damaged neurons.Carbon nanotubes and graphene are allotropes of carbon that have been exploited by researchers because of their excellent physical properties and their ability to interface with neurons and neuronal circuits.In the future, it is hoped that the benefits of nanotechnologies will outweigh their risks, and that the next decade will present huge scope for developing and delivering technologies in the field of neuroscience.

View Article: PubMed Central - PubMed

Affiliation: IJN-UTM Cardiovascular Engineering Centre, Faculty of Biosciences and Medical Engineering, Universiti Teknologi Malaysia, Johor Bahru, Malaysia.

ABSTRACT
Neuroregeneration is the regrowth or repair of nervous tissues, cells, or cell products involved in neurodegeneration and inflammatory diseases of the nervous system like Alzheimer's disease and Parkinson's disease. Nowadays, application of nanotechnology is commonly used in developing nanomedicines to advance pharmacokinetics and drug delivery exclusively for central nervous system pathologies. In addition, nanomedical advances are leading to therapies that disrupt disarranged protein aggregation in the central nervous system, deliver functional neuroprotective growth factors, and change the oxidative stress and excitotoxicity of affected neural tissues to regenerate the damaged neurons. Carbon nanotubes and graphene are allotropes of carbon that have been exploited by researchers because of their excellent physical properties and their ability to interface with neurons and neuronal circuits. This review describes the role of carbon nanotubes and graphene in neuroregeneration. In the future, it is hoped that the benefits of nanotechnologies will outweigh their risks, and that the next decade will present huge scope for developing and delivering technologies in the field of neuroscience.

No MeSH data available.


Related in: MedlinePlus

Common mechanisms involved in neurodegeneration.
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f2-ijn-10-4267: Common mechanisms involved in neurodegeneration.

Mentions: Neurological disorders result from functional abnormality or disturbance of the nervous system, are assessed by neurological examination, and are treated within the specialties of neurology and clinical neuropsychology. AD and PD are the most common types of neurodegenerative disease7 and are briefly outlined in this review. Common mechanisms of neurodegeneration include dysfunction of the mitochondria, increased oxidative stress levels, excitotoxicity, aggregation of proteins, accumulation of iron, and inflammatory changes (Figure 2).


Carbon nanotubes and graphene as emerging candidates in neuroregeneration and neurodrug delivery.

John AA, Subramanian AP, Vellayappan MV, Balaji A, Mohandas H, Jaganathan SK - Int J Nanomedicine (2015)

Common mechanisms involved in neurodegeneration.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4495782&req=5

f2-ijn-10-4267: Common mechanisms involved in neurodegeneration.
Mentions: Neurological disorders result from functional abnormality or disturbance of the nervous system, are assessed by neurological examination, and are treated within the specialties of neurology and clinical neuropsychology. AD and PD are the most common types of neurodegenerative disease7 and are briefly outlined in this review. Common mechanisms of neurodegeneration include dysfunction of the mitochondria, increased oxidative stress levels, excitotoxicity, aggregation of proteins, accumulation of iron, and inflammatory changes (Figure 2).

Bottom Line: In addition, nanomedical advances are leading to therapies that disrupt disarranged protein aggregation in the central nervous system, deliver functional neuroprotective growth factors, and change the oxidative stress and excitotoxicity of affected neural tissues to regenerate the damaged neurons.Carbon nanotubes and graphene are allotropes of carbon that have been exploited by researchers because of their excellent physical properties and their ability to interface with neurons and neuronal circuits.In the future, it is hoped that the benefits of nanotechnologies will outweigh their risks, and that the next decade will present huge scope for developing and delivering technologies in the field of neuroscience.

View Article: PubMed Central - PubMed

Affiliation: IJN-UTM Cardiovascular Engineering Centre, Faculty of Biosciences and Medical Engineering, Universiti Teknologi Malaysia, Johor Bahru, Malaysia.

ABSTRACT
Neuroregeneration is the regrowth or repair of nervous tissues, cells, or cell products involved in neurodegeneration and inflammatory diseases of the nervous system like Alzheimer's disease and Parkinson's disease. Nowadays, application of nanotechnology is commonly used in developing nanomedicines to advance pharmacokinetics and drug delivery exclusively for central nervous system pathologies. In addition, nanomedical advances are leading to therapies that disrupt disarranged protein aggregation in the central nervous system, deliver functional neuroprotective growth factors, and change the oxidative stress and excitotoxicity of affected neural tissues to regenerate the damaged neurons. Carbon nanotubes and graphene are allotropes of carbon that have been exploited by researchers because of their excellent physical properties and their ability to interface with neurons and neuronal circuits. This review describes the role of carbon nanotubes and graphene in neuroregeneration. In the future, it is hoped that the benefits of nanotechnologies will outweigh their risks, and that the next decade will present huge scope for developing and delivering technologies in the field of neuroscience.

No MeSH data available.


Related in: MedlinePlus