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DOME/GALT type adenocarcimoma of the colon: a case report, literature review and a unified phenotypic categorization.

Kannuna H, Rubio CA, Silverio PC, Girardin M, Goossens N, Rubbia-Brandt L, Puppa G - Diagn Pathol (2015)

Bottom Line: Several types of colorectal cancers are associated with a prominent lymphoid component, which is considered a positive prognostic factor.The submucosal invasive component showed low-grade architectural features that included cystically dilated glands containing eosinohilic debris.After 3 years, the patient remains free of recurrence.

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical Pathology, Geneva University Hospital, 1 rue Michel-Servet, 1211, Geneva, Switzerland. Hala.Kannuna@hcuge.ch.

ABSTRACT
Several types of colorectal cancers are associated with a prominent lymphoid component, which is considered a positive prognostic factor. We report a case of a dome-type carcinoma of the cecum in a 57 year old female. The sessile, non-polypoid lesion histologically consisted of a tubulovillous adenoma with low-grade dysplasia. The submucosal invasive component showed low-grade architectural features that included cystically dilated glands containing eosinohilic debris. Immunohistochemical studies displayed retention of the four mistmach repair proteins, consistent with a stable phenotype. After 3 years, the patient remains free of recurrence. A literature review highlighted striking similarities between dome-type carcinoma and the gut-associated lymphoid tissue carcinoma, the two sharing an intimate association with the gut associated lymphoid tissue.The two variants might therefore be grouped into a unified category.

No MeSH data available.


Related in: MedlinePlus

Adenocarcinoma with low-grade architectural features including cystically dilated glands with eosinohilic debris. Tumor cell cytoplasmic eosinophilia is also evident (H&E; ×50)
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Fig4: Adenocarcinoma with low-grade architectural features including cystically dilated glands with eosinohilic debris. Tumor cell cytoplasmic eosinophilia is also evident (H&E; ×50)

Mentions: The submucosal tumour was surrounded by a prominent lymphoid tissue exhibiting reactive germinal centres (Figs. 3 and 4). The glands were cystically dilated with intraluminal eosinophilic debris (Fig. 4). A clear space was evident separating the glandular epithelium from the intraglandular material. Neoplastic cells lining the glands were single-layered, cuboidal to columnar, with cytoplasmic eosinophilia and moderate atypia. No desmoplasia, tumor infiltrating lymphocytes or goblet cells were observed. Eleven lymph nodes recovered, all of which were negatives for metastasis.Fig. 4


DOME/GALT type adenocarcimoma of the colon: a case report, literature review and a unified phenotypic categorization.

Kannuna H, Rubio CA, Silverio PC, Girardin M, Goossens N, Rubbia-Brandt L, Puppa G - Diagn Pathol (2015)

Adenocarcinoma with low-grade architectural features including cystically dilated glands with eosinohilic debris. Tumor cell cytoplasmic eosinophilia is also evident (H&E; ×50)
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4495708&req=5

Fig4: Adenocarcinoma with low-grade architectural features including cystically dilated glands with eosinohilic debris. Tumor cell cytoplasmic eosinophilia is also evident (H&E; ×50)
Mentions: The submucosal tumour was surrounded by a prominent lymphoid tissue exhibiting reactive germinal centres (Figs. 3 and 4). The glands were cystically dilated with intraluminal eosinophilic debris (Fig. 4). A clear space was evident separating the glandular epithelium from the intraglandular material. Neoplastic cells lining the glands were single-layered, cuboidal to columnar, with cytoplasmic eosinophilia and moderate atypia. No desmoplasia, tumor infiltrating lymphocytes or goblet cells were observed. Eleven lymph nodes recovered, all of which were negatives for metastasis.Fig. 4

Bottom Line: Several types of colorectal cancers are associated with a prominent lymphoid component, which is considered a positive prognostic factor.The submucosal invasive component showed low-grade architectural features that included cystically dilated glands containing eosinohilic debris.After 3 years, the patient remains free of recurrence.

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical Pathology, Geneva University Hospital, 1 rue Michel-Servet, 1211, Geneva, Switzerland. Hala.Kannuna@hcuge.ch.

ABSTRACT
Several types of colorectal cancers are associated with a prominent lymphoid component, which is considered a positive prognostic factor. We report a case of a dome-type carcinoma of the cecum in a 57 year old female. The sessile, non-polypoid lesion histologically consisted of a tubulovillous adenoma with low-grade dysplasia. The submucosal invasive component showed low-grade architectural features that included cystically dilated glands containing eosinohilic debris. Immunohistochemical studies displayed retention of the four mistmach repair proteins, consistent with a stable phenotype. After 3 years, the patient remains free of recurrence. A literature review highlighted striking similarities between dome-type carcinoma and the gut-associated lymphoid tissue carcinoma, the two sharing an intimate association with the gut associated lymphoid tissue.The two variants might therefore be grouped into a unified category.

No MeSH data available.


Related in: MedlinePlus