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DOME/GALT type adenocarcimoma of the colon: a case report, literature review and a unified phenotypic categorization.

Kannuna H, Rubio CA, Silverio PC, Girardin M, Goossens N, Rubbia-Brandt L, Puppa G - Diagn Pathol (2015)

Bottom Line: Several types of colorectal cancers are associated with a prominent lymphoid component, which is considered a positive prognostic factor.The submucosal invasive component showed low-grade architectural features that included cystically dilated glands containing eosinohilic debris.After 3 years, the patient remains free of recurrence.

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical Pathology, Geneva University Hospital, 1 rue Michel-Servet, 1211, Geneva, Switzerland. Hala.Kannuna@hcuge.ch.

ABSTRACT
Several types of colorectal cancers are associated with a prominent lymphoid component, which is considered a positive prognostic factor. We report a case of a dome-type carcinoma of the cecum in a 57 year old female. The sessile, non-polypoid lesion histologically consisted of a tubulovillous adenoma with low-grade dysplasia. The submucosal invasive component showed low-grade architectural features that included cystically dilated glands containing eosinohilic debris. Immunohistochemical studies displayed retention of the four mistmach repair proteins, consistent with a stable phenotype. After 3 years, the patient remains free of recurrence. A literature review highlighted striking similarities between dome-type carcinoma and the gut-associated lymphoid tissue carcinoma, the two sharing an intimate association with the gut associated lymphoid tissue.The two variants might therefore be grouped into a unified category.

No MeSH data available.


Related in: MedlinePlus

The submucosal invasive component in association with GALT (H&E; ×10)
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Fig3: The submucosal invasive component in association with GALT (H&E; ×10)

Mentions: The cecal mass was a moderately differentiated adenocarcinoma evolving from a tubulovillous adenoma, invading the submucosa (Figs. 2 and 3).Fig. 2


DOME/GALT type adenocarcimoma of the colon: a case report, literature review and a unified phenotypic categorization.

Kannuna H, Rubio CA, Silverio PC, Girardin M, Goossens N, Rubbia-Brandt L, Puppa G - Diagn Pathol (2015)

The submucosal invasive component in association with GALT (H&E; ×10)
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4495708&req=5

Fig3: The submucosal invasive component in association with GALT (H&E; ×10)
Mentions: The cecal mass was a moderately differentiated adenocarcinoma evolving from a tubulovillous adenoma, invading the submucosa (Figs. 2 and 3).Fig. 2

Bottom Line: Several types of colorectal cancers are associated with a prominent lymphoid component, which is considered a positive prognostic factor.The submucosal invasive component showed low-grade architectural features that included cystically dilated glands containing eosinohilic debris.After 3 years, the patient remains free of recurrence.

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical Pathology, Geneva University Hospital, 1 rue Michel-Servet, 1211, Geneva, Switzerland. Hala.Kannuna@hcuge.ch.

ABSTRACT
Several types of colorectal cancers are associated with a prominent lymphoid component, which is considered a positive prognostic factor. We report a case of a dome-type carcinoma of the cecum in a 57 year old female. The sessile, non-polypoid lesion histologically consisted of a tubulovillous adenoma with low-grade dysplasia. The submucosal invasive component showed low-grade architectural features that included cystically dilated glands containing eosinohilic debris. Immunohistochemical studies displayed retention of the four mistmach repair proteins, consistent with a stable phenotype. After 3 years, the patient remains free of recurrence. A literature review highlighted striking similarities between dome-type carcinoma and the gut-associated lymphoid tissue carcinoma, the two sharing an intimate association with the gut associated lymphoid tissue.The two variants might therefore be grouped into a unified category.

No MeSH data available.


Related in: MedlinePlus