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Acrokeratosis paraneoplastica in serous ovarian carcinoma: case report.

Hempen A, Samartzis EP, Kamarachev J, Fink D, Dedes KJ - BMC Cancer (2015)

Bottom Line: Acrokeratosis paraneoplastica is a rare paraneoplastic phenomenon associated with upper aerodigestive tract carcinomas, usually manifesting as psoriasiform keratosis over the acral sites.Clinical and histological examination, as well as the course of disease, confirmed the diagnosis of a paraneoplastic plantar keratosis.Under systemic chemotherapy with carboplatin and paclitaxel the lesion resolved gradually in concordance with tumour marker CA 125.

View Article: PubMed Central - PubMed

Affiliation: Department of Gynaecology, University Hospital Zurich, Frauenklinikstrasse, 8091, Zurich, Switzerland. aline.hempen@usz.ch.

ABSTRACT

Background: Acrokeratosis paraneoplastica is a rare paraneoplastic phenomenon associated with upper aerodigestive tract carcinomas, usually manifesting as psoriasiform keratosis over the acral sites. It is primarily seen in white males above the age of 40 years. Here we report a case of paraneoplastic acrokeratosis in a woman with serous ovarian cancer. To the best of our knowledge, no similar case has been reported previously.

Case presentation: We report the case of a 60-year-old woman diagnosed with a serous ovarian cancer and complaining of a thickening and peeling of the skin on her feet. Clinical and histological examination, as well as the course of disease, confirmed the diagnosis of a paraneoplastic plantar keratosis. Under systemic chemotherapy with carboplatin and paclitaxel the lesion resolved gradually in concordance with tumour marker CA 125.

Conclusions: We present the reported case of paraneoplastic acrokeratosis associated with advanced high-grade ovarian cancer.

No MeSH data available.


Related in: MedlinePlus

Laminar plantar hyperkeratosis on both feet with enhancement of areas under compressive stress (a) before treatment and (b) after three cycles of chemotherapy (punch marks on left sole)
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Fig2: Laminar plantar hyperkeratosis on both feet with enhancement of areas under compressive stress (a) before treatment and (b) after three cycles of chemotherapy (punch marks on left sole)

Mentions: Already prior to surgery, approximately when the ovarian cancer was diagnosed, the patient complained about a disturbing skin alteration on both her feet. Inspection revealed laminar hyperkeratosis and scaling of the plantar skin (enhanced in areas under compressive stress), which was unbeknownst to her. Dermatological examination as well as punch biopsy of the skin (Fig. 1a,b) suggested the presence of a paraneoplastic acrokeratosis. Histology of plantar skin revealed compact hyperkeratosis and irregular epidermal hyperplasia. Mycosis was excluded histologically. A regression of the cutaneous lesion together with the normalisation of the CA125 tumour marker (a drop to 9.3 U/mL) under first-line chemotherapy containing carboplatin and paclitaxel was observed, which further supported the suspected diagnosis of a paraneoplastic phenomenon (Fig. 2a,b). Cutaneous eruptions in other areas (eg. face, hands), as seen in some cases of paraneoplastic acrokeratosis, could not be found [4, 7].Fig. 1


Acrokeratosis paraneoplastica in serous ovarian carcinoma: case report.

Hempen A, Samartzis EP, Kamarachev J, Fink D, Dedes KJ - BMC Cancer (2015)

Laminar plantar hyperkeratosis on both feet with enhancement of areas under compressive stress (a) before treatment and (b) after three cycles of chemotherapy (punch marks on left sole)
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4495707&req=5

Fig2: Laminar plantar hyperkeratosis on both feet with enhancement of areas under compressive stress (a) before treatment and (b) after three cycles of chemotherapy (punch marks on left sole)
Mentions: Already prior to surgery, approximately when the ovarian cancer was diagnosed, the patient complained about a disturbing skin alteration on both her feet. Inspection revealed laminar hyperkeratosis and scaling of the plantar skin (enhanced in areas under compressive stress), which was unbeknownst to her. Dermatological examination as well as punch biopsy of the skin (Fig. 1a,b) suggested the presence of a paraneoplastic acrokeratosis. Histology of plantar skin revealed compact hyperkeratosis and irregular epidermal hyperplasia. Mycosis was excluded histologically. A regression of the cutaneous lesion together with the normalisation of the CA125 tumour marker (a drop to 9.3 U/mL) under first-line chemotherapy containing carboplatin and paclitaxel was observed, which further supported the suspected diagnosis of a paraneoplastic phenomenon (Fig. 2a,b). Cutaneous eruptions in other areas (eg. face, hands), as seen in some cases of paraneoplastic acrokeratosis, could not be found [4, 7].Fig. 1

Bottom Line: Acrokeratosis paraneoplastica is a rare paraneoplastic phenomenon associated with upper aerodigestive tract carcinomas, usually manifesting as psoriasiform keratosis over the acral sites.Clinical and histological examination, as well as the course of disease, confirmed the diagnosis of a paraneoplastic plantar keratosis.Under systemic chemotherapy with carboplatin and paclitaxel the lesion resolved gradually in concordance with tumour marker CA 125.

View Article: PubMed Central - PubMed

Affiliation: Department of Gynaecology, University Hospital Zurich, Frauenklinikstrasse, 8091, Zurich, Switzerland. aline.hempen@usz.ch.

ABSTRACT

Background: Acrokeratosis paraneoplastica is a rare paraneoplastic phenomenon associated with upper aerodigestive tract carcinomas, usually manifesting as psoriasiform keratosis over the acral sites. It is primarily seen in white males above the age of 40 years. Here we report a case of paraneoplastic acrokeratosis in a woman with serous ovarian cancer. To the best of our knowledge, no similar case has been reported previously.

Case presentation: We report the case of a 60-year-old woman diagnosed with a serous ovarian cancer and complaining of a thickening and peeling of the skin on her feet. Clinical and histological examination, as well as the course of disease, confirmed the diagnosis of a paraneoplastic plantar keratosis. Under systemic chemotherapy with carboplatin and paclitaxel the lesion resolved gradually in concordance with tumour marker CA 125.

Conclusions: We present the reported case of paraneoplastic acrokeratosis associated with advanced high-grade ovarian cancer.

No MeSH data available.


Related in: MedlinePlus