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Accurate quantitative measurements of brachial artery cross-sectional vascular area and vascular volume elastic modulus using automated oscillometric measurements: comparison with brachial artery ultrasound.

Tomiyama Y, Yoshinaga K, Fujii S, Ochi N, Inoue M, Nishida M, Aziki K, Horie T, Katoh C, Tamaki N - Hypertens. Res. (2015)

Bottom Line: Rest eA and VE measurement showed good reproducibility (eA: intraclass correlation coefficient (ICC)=0.88, V(E): ICC=0.78).V(E) was also decreased (0.81±0.16 vs. 0.65±0.11 mm Hg/%, P<0.001) after NTG.Therefore, this is a reliable approach and this modality may have practical application to automatically assess muscular artery diameter and elasticity in clinical or epidemiological settings.

View Article: PubMed Central - PubMed

Affiliation: Department of Nuclear Medicine, Hokkaido University Graduate School of Medicine, Hokkaido, Japan.

ABSTRACT
Increasing vascular diameter and attenuated vascular elasticity may be reliable markers for atherosclerotic risk assessment. However, previous measurements have been complex, operator-dependent or invasive. Recently, we developed a new automated oscillometric method to measure a brachial artery's estimated area (eA) and volume elastic modulus (V(E)). The aim of this study was to investigate the reliability of new automated oscillometric measurement of eA and V(E). Rest eA and V(E) were measured using the recently developed automated detector with the oscillometric method. eA was estimated using pressure/volume curves and V(E) was defined as follows (V(E)=Δ pressure/ (100 × Δ area/area) mm Hg/%). Sixteen volunteers (age 35.2±13.1 years) underwent the oscillometric measurements and brachial ultrasound at rest and under nitroglycerin (NTG) administration. Oscillometric measurement was performed twice on different days. The rest eA correlated with ultrasound-measured brachial artery area (r=0.77, P<0.001). Rest eA and VE measurement showed good reproducibility (eA: intraclass correlation coefficient (ICC)=0.88, V(E): ICC=0.78). Under NTG stress, eA was significantly increased (12.3±3.0 vs. 17.1±4.6 mm(2), P<0.001), and this was similar to the case with ultrasound evaluation (4.46±0.72 vs. 4.73±0.75 mm, P<0.001). V(E) was also decreased (0.81±0.16 vs. 0.65±0.11 mm Hg/%, P<0.001) after NTG. Cross-sectional vascular area calculated using this automated oscillometric measurement correlated with ultrasound measurement and showed good reproducibility. Therefore, this is a reliable approach and this modality may have practical application to automatically assess muscular artery diameter and elasticity in clinical or epidemiological settings.

No MeSH data available.


Correlation between age and other parameters. (a) Correlation between age and ultrasound measurements of brachial artery diameter. (b) Correlation between age and oscillometric measurement of estimated cross-sectional area (eA). (c) Correlation between age and oscillometric measurement of volume elastic modulus (VE).
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fig4: Correlation between age and other parameters. (a) Correlation between age and ultrasound measurements of brachial artery diameter. (b) Correlation between age and oscillometric measurement of estimated cross-sectional area (eA). (c) Correlation between age and oscillometric measurement of volume elastic modulus (VE).

Mentions: There was no significant correlation between ultrasound-measured brachial artery diameter and age (r=0.32, P=0.26, Figure 4a). In contrast, there was a significant correlation between eA and increasing age (r=0.56, P=0.026, Figure 4b). Rest VE also showed significant correlation with increasing age (r=0.81, P<0.001, Figure 4c).


Accurate quantitative measurements of brachial artery cross-sectional vascular area and vascular volume elastic modulus using automated oscillometric measurements: comparison with brachial artery ultrasound.

Tomiyama Y, Yoshinaga K, Fujii S, Ochi N, Inoue M, Nishida M, Aziki K, Horie T, Katoh C, Tamaki N - Hypertens. Res. (2015)

Correlation between age and other parameters. (a) Correlation between age and ultrasound measurements of brachial artery diameter. (b) Correlation between age and oscillometric measurement of estimated cross-sectional area (eA). (c) Correlation between age and oscillometric measurement of volume elastic modulus (VE).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4495642&req=5

fig4: Correlation between age and other parameters. (a) Correlation between age and ultrasound measurements of brachial artery diameter. (b) Correlation between age and oscillometric measurement of estimated cross-sectional area (eA). (c) Correlation between age and oscillometric measurement of volume elastic modulus (VE).
Mentions: There was no significant correlation between ultrasound-measured brachial artery diameter and age (r=0.32, P=0.26, Figure 4a). In contrast, there was a significant correlation between eA and increasing age (r=0.56, P=0.026, Figure 4b). Rest VE also showed significant correlation with increasing age (r=0.81, P<0.001, Figure 4c).

Bottom Line: Rest eA and VE measurement showed good reproducibility (eA: intraclass correlation coefficient (ICC)=0.88, V(E): ICC=0.78).V(E) was also decreased (0.81±0.16 vs. 0.65±0.11 mm Hg/%, P<0.001) after NTG.Therefore, this is a reliable approach and this modality may have practical application to automatically assess muscular artery diameter and elasticity in clinical or epidemiological settings.

View Article: PubMed Central - PubMed

Affiliation: Department of Nuclear Medicine, Hokkaido University Graduate School of Medicine, Hokkaido, Japan.

ABSTRACT
Increasing vascular diameter and attenuated vascular elasticity may be reliable markers for atherosclerotic risk assessment. However, previous measurements have been complex, operator-dependent or invasive. Recently, we developed a new automated oscillometric method to measure a brachial artery's estimated area (eA) and volume elastic modulus (V(E)). The aim of this study was to investigate the reliability of new automated oscillometric measurement of eA and V(E). Rest eA and V(E) were measured using the recently developed automated detector with the oscillometric method. eA was estimated using pressure/volume curves and V(E) was defined as follows (V(E)=Δ pressure/ (100 × Δ area/area) mm Hg/%). Sixteen volunteers (age 35.2±13.1 years) underwent the oscillometric measurements and brachial ultrasound at rest and under nitroglycerin (NTG) administration. Oscillometric measurement was performed twice on different days. The rest eA correlated with ultrasound-measured brachial artery area (r=0.77, P<0.001). Rest eA and VE measurement showed good reproducibility (eA: intraclass correlation coefficient (ICC)=0.88, V(E): ICC=0.78). Under NTG stress, eA was significantly increased (12.3±3.0 vs. 17.1±4.6 mm(2), P<0.001), and this was similar to the case with ultrasound evaluation (4.46±0.72 vs. 4.73±0.75 mm, P<0.001). V(E) was also decreased (0.81±0.16 vs. 0.65±0.11 mm Hg/%, P<0.001) after NTG. Cross-sectional vascular area calculated using this automated oscillometric measurement correlated with ultrasound measurement and showed good reproducibility. Therefore, this is a reliable approach and this modality may have practical application to automatically assess muscular artery diameter and elasticity in clinical or epidemiological settings.

No MeSH data available.