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Grave's disease associated with immunoglobulin A nephropathy: A rare association.

Khan I, Bhat RA, Khan I, Hameed I - Indian J Nephrol (2015 Jul-Aug)

Bottom Line: We report a case of 20-year-old female with Grave's disease who presented with edema, facial puffiness, and decreased urine output.She was found to be hypertensive with renal failure and nephrotic range proteinuria.The patient was treated with oral corticosteroids (1 mg/kg/day).

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Sher-i-Kashmir Institute of Medical Sciences, Jammu, Jammu and Kashmir, India.

ABSTRACT
Immunoglobulin A (Ig A) nephropathy is the most common form of primary glomerulonephritis. The association of Ig A nephropathy with Grave's disease has not been reported so far. We report a case of 20-year-old female with Grave's disease who presented with edema, facial puffiness, and decreased urine output. She was found to be hypertensive with renal failure and nephrotic range proteinuria. Renal biopsy revealed features of Ig A nephropathy. The patient was treated with oral corticosteroids (1 mg/kg/day). To our knowledge, this is the first case showing association of Grave's disease with Ig A nephropathy.

No MeSH data available.


Related in: MedlinePlus

Microphotograph showing histopathological examination showing globally sclerosed glomeruli tuft sclerosis with segmental endocapillary cellularity. Tubular atrophy with loss of brush borders is evident
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Figure 1: Microphotograph showing histopathological examination showing globally sclerosed glomeruli tuft sclerosis with segmental endocapillary cellularity. Tubular atrophy with loss of brush borders is evident

Mentions: Renal biopsy revealed 23 glomeruli, 12 (52.1%) of which were globally sclerosed. Among the remaining glomeruli, 7 (30.4%) revealed segmental tuft sclerosis and three glomeruli (13%) revealed segmental endocapillary cellularity. Extracapillary proliferation and partial fibrocellular crescents were seen in 2 (8.69%) glomeruli. Tubular atrophy and interstitial fibrosis involved 40–45% of the sample. Viable tubules showed prominent cytoplasmic vacuolar changes and evidence of patchy acute injury with epithelial simplification and loss of brush borders. Arteries showed medial thickening and fibrointimal sclerosis with duplication of internal elastic lamina and focal mucoid degeneration while arterioles revealed variably thickened walls with subendothelial transmural hyalinosis 1 [Figure 1].


Grave's disease associated with immunoglobulin A nephropathy: A rare association.

Khan I, Bhat RA, Khan I, Hameed I - Indian J Nephrol (2015 Jul-Aug)

Microphotograph showing histopathological examination showing globally sclerosed glomeruli tuft sclerosis with segmental endocapillary cellularity. Tubular atrophy with loss of brush borders is evident
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4495482&req=5

Figure 1: Microphotograph showing histopathological examination showing globally sclerosed glomeruli tuft sclerosis with segmental endocapillary cellularity. Tubular atrophy with loss of brush borders is evident
Mentions: Renal biopsy revealed 23 glomeruli, 12 (52.1%) of which were globally sclerosed. Among the remaining glomeruli, 7 (30.4%) revealed segmental tuft sclerosis and three glomeruli (13%) revealed segmental endocapillary cellularity. Extracapillary proliferation and partial fibrocellular crescents were seen in 2 (8.69%) glomeruli. Tubular atrophy and interstitial fibrosis involved 40–45% of the sample. Viable tubules showed prominent cytoplasmic vacuolar changes and evidence of patchy acute injury with epithelial simplification and loss of brush borders. Arteries showed medial thickening and fibrointimal sclerosis with duplication of internal elastic lamina and focal mucoid degeneration while arterioles revealed variably thickened walls with subendothelial transmural hyalinosis 1 [Figure 1].

Bottom Line: We report a case of 20-year-old female with Grave's disease who presented with edema, facial puffiness, and decreased urine output.She was found to be hypertensive with renal failure and nephrotic range proteinuria.The patient was treated with oral corticosteroids (1 mg/kg/day).

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Sher-i-Kashmir Institute of Medical Sciences, Jammu, Jammu and Kashmir, India.

ABSTRACT
Immunoglobulin A (Ig A) nephropathy is the most common form of primary glomerulonephritis. The association of Ig A nephropathy with Grave's disease has not been reported so far. We report a case of 20-year-old female with Grave's disease who presented with edema, facial puffiness, and decreased urine output. She was found to be hypertensive with renal failure and nephrotic range proteinuria. Renal biopsy revealed features of Ig A nephropathy. The patient was treated with oral corticosteroids (1 mg/kg/day). To our knowledge, this is the first case showing association of Grave's disease with Ig A nephropathy.

No MeSH data available.


Related in: MedlinePlus