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Antioxidant vitamins status in children and young adults undergoing dialysis: A single center study.

Naseri M, Shahri HM, Horri M, Rasoli Z, Salemian F, Jahanshahi S, Moeenolroayaa G, Pourhasan M - Indian J Nephrol (2015 Jul-Aug)

Bottom Line: Six (13.9%) patients were switched from PD to HD or vice versa.The serum vitamin C levels were low in 5 (13.5%) and normal in 32 (86.5%) patients. vitamin C deficiency was more prevalent in HD versus continuous ambulatory peritoneal dialysis patients (P = 0.128).Vitamin E deficiency was a prevalent finding and supplementary vitamin C 30-60 mg/day was sufficient to prevent deficiency.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatric Nephrology, Dr. Sheikh Children Hospital, Mashhad, Iran.

ABSTRACT
Vitamin E and C are well-known antioxidant vitamins. Oxidative stress is common in chronic kidney diseases. We evaluated 43 dialysis subjects prospectively in a cross-sectional survey. Serum vitamin E concentration was checked in all subjects; 37 cases underwent blood sampling for measurement of serum vitamin C. The enrolled subjects consisted of 12 (27.9%) peritoneal dialysis (PD) and 25 (58.1%) hemodialysis (HD) patients. Six (13.9%) patients were switched from PD to HD or vice versa. Serum concentration of vitamin E was normal, low and high in 9 (20.9%), 31 (72%) and 3 (7.1%) patients, respectively. There were no significant differences regarding age, gender, modality and duration of dialysis, and characteristics of dialysis sessions, mean serum blood urea nitrogen, and albumin levels between vitamin E deficient cases with those with normal serum vitamin E concentration (P > 0.05 for all). The serum vitamin C levels were low in 5 (13.5%) and normal in 32 (86.5%) patients. vitamin C deficiency was more prevalent in HD versus continuous ambulatory peritoneal dialysis patients (P = 0.128). Mean serum vitamin C concentration was higher in patients who were supplemented by vitamin C compared with those who didn't receive the vitamin supplement (P = 0.043). Vitamin E deficiency was a prevalent finding and supplementary vitamin C 30-60 mg/day was sufficient to prevent deficiency. Regular assessments of serum vitamin E level may be needed in dialysis centers.

No MeSH data available.


Related in: MedlinePlus

Serum vitamin E concentration changes according to dialysis modalities
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Figure 2: Serum vitamin E concentration changes according to dialysis modalities

Mentions: In PD group, 7 cases were supplemented by vitamin C regularly, four had stopped the vitamin consumption and 1 patient was not sure about regular consumption. Vitamin C and E deficiencies were reported in 2 and 13 girls, respectively and 3 and 18 boys had low serum vitamin C and E concentration, respectively. Frequency of vitamin C and E deficiencies was as common in boys as in girls [Tables 1 and 2]. Combined vitamin E and C deficiencies were detected in 3 of 37 (8.3%) patients. All cases with combined vitamin E and C deficiencies were HD patients! Figures 1 and 2 present the ranges of serum vitamin E and C concentration changes according to dialysis modalities. Mean serum Hb levels (in recent 2 months) in patients with vitamin C deficiency (9.6 ± 2.96 mg/dl) were not significantly lower than those with normal serum vitamin C levels (10.62 ± 2.27 mg/dl) (P = 0.55).


Antioxidant vitamins status in children and young adults undergoing dialysis: A single center study.

Naseri M, Shahri HM, Horri M, Rasoli Z, Salemian F, Jahanshahi S, Moeenolroayaa G, Pourhasan M - Indian J Nephrol (2015 Jul-Aug)

Serum vitamin E concentration changes according to dialysis modalities
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4495474&req=5

Figure 2: Serum vitamin E concentration changes according to dialysis modalities
Mentions: In PD group, 7 cases were supplemented by vitamin C regularly, four had stopped the vitamin consumption and 1 patient was not sure about regular consumption. Vitamin C and E deficiencies were reported in 2 and 13 girls, respectively and 3 and 18 boys had low serum vitamin C and E concentration, respectively. Frequency of vitamin C and E deficiencies was as common in boys as in girls [Tables 1 and 2]. Combined vitamin E and C deficiencies were detected in 3 of 37 (8.3%) patients. All cases with combined vitamin E and C deficiencies were HD patients! Figures 1 and 2 present the ranges of serum vitamin E and C concentration changes according to dialysis modalities. Mean serum Hb levels (in recent 2 months) in patients with vitamin C deficiency (9.6 ± 2.96 mg/dl) were not significantly lower than those with normal serum vitamin C levels (10.62 ± 2.27 mg/dl) (P = 0.55).

Bottom Line: Six (13.9%) patients were switched from PD to HD or vice versa.The serum vitamin C levels were low in 5 (13.5%) and normal in 32 (86.5%) patients. vitamin C deficiency was more prevalent in HD versus continuous ambulatory peritoneal dialysis patients (P = 0.128).Vitamin E deficiency was a prevalent finding and supplementary vitamin C 30-60 mg/day was sufficient to prevent deficiency.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatric Nephrology, Dr. Sheikh Children Hospital, Mashhad, Iran.

ABSTRACT
Vitamin E and C are well-known antioxidant vitamins. Oxidative stress is common in chronic kidney diseases. We evaluated 43 dialysis subjects prospectively in a cross-sectional survey. Serum vitamin E concentration was checked in all subjects; 37 cases underwent blood sampling for measurement of serum vitamin C. The enrolled subjects consisted of 12 (27.9%) peritoneal dialysis (PD) and 25 (58.1%) hemodialysis (HD) patients. Six (13.9%) patients were switched from PD to HD or vice versa. Serum concentration of vitamin E was normal, low and high in 9 (20.9%), 31 (72%) and 3 (7.1%) patients, respectively. There were no significant differences regarding age, gender, modality and duration of dialysis, and characteristics of dialysis sessions, mean serum blood urea nitrogen, and albumin levels between vitamin E deficient cases with those with normal serum vitamin E concentration (P > 0.05 for all). The serum vitamin C levels were low in 5 (13.5%) and normal in 32 (86.5%) patients. vitamin C deficiency was more prevalent in HD versus continuous ambulatory peritoneal dialysis patients (P = 0.128). Mean serum vitamin C concentration was higher in patients who were supplemented by vitamin C compared with those who didn't receive the vitamin supplement (P = 0.043). Vitamin E deficiency was a prevalent finding and supplementary vitamin C 30-60 mg/day was sufficient to prevent deficiency. Regular assessments of serum vitamin E level may be needed in dialysis centers.

No MeSH data available.


Related in: MedlinePlus