Limits...
Spectrum of renal involvement in hematolymphoid neoplasms: Renal biopsy findings of 12 cases.

Vankalakunti M, Rohan A, Vishwanath S, Rampure S, Bonu R, Babu K, Ballal HS - Indian J Nephrol (2015 Jul-Aug)

Bottom Line: We observed that renal dysfunction was predominantly a direct effect, that is, lymphomatous invasion.Paraneoplastic glomerulopathic changes occur in the form of MPGN.Proteinuria of >2 g/day correlated with glomerular disease.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Manipal Hospital, Bengaluru, Karnataka, India.

ABSTRACT
Spectrum of causes for renal dysfunction in patients with hematolymphoid malignancy (excluding plasma cell dyscrasia) is varied. A retrospective evaluation of "native" renal biopsies referred to our institute during the period from January 2010 to December 2013 revealed 12 cases. Age ranged between 7 and 69 (median 54.5) years. All patients were males. The neoplasms included non-Hodgkin lymphoma, chronic lymphocytic leukemia, acute lymphoblastic leukemia, Burkitt's lymphoma, intravascular lymphoma, Hodgkin lymphoma and chronic myeloid leukemia. Proteinuria was noted in 66% of the patients (nephrotic range in 5, subnephrotic range in 3). Renal insufficiency was noted in 100% patients. Malignancy-related kidney injury was noted in 75% of the cases. Renal histology showed lymphomatous infiltration (8), membranoproliferative glomerulonephritis (MPGN) (3), intracapillary monoclonal deposit disease (1) and intravascular lymphoma (1). Distribution of lymphomatous infiltration was diffuse in 50% and focal in 50%. We observed that renal dysfunction was predominantly a direct effect, that is, lymphomatous invasion. Paraneoplastic glomerulopathic changes occur in the form of MPGN. Proteinuria of >2 g/day correlated with glomerular disease.

No MeSH data available.


Related in: MedlinePlus

(a) Medium- to large-sized monotonous lymphoid cells filling peritubular capillaries. (b) Some of the lymphoid cells are plasmacytoid with coarse chromatin. Inset shows positive staining with CD20
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4495473&req=5

Figure 4: (a) Medium- to large-sized monotonous lymphoid cells filling peritubular capillaries. (b) Some of the lymphoid cells are plasmacytoid with coarse chromatin. Inset shows positive staining with CD20

Mentions: Large- to medium-sized immature lymphoid cells were seen predominantly in the lumen of peritubular capillaries. Cells were CD20+/CD3− with kappa light chain restriction [Figure 4]. CD34 highlighted the peritubular capillaries. There was no evidence of nodal enlargement either on clinical examination or computed tomography imaging of the whole body.


Spectrum of renal involvement in hematolymphoid neoplasms: Renal biopsy findings of 12 cases.

Vankalakunti M, Rohan A, Vishwanath S, Rampure S, Bonu R, Babu K, Ballal HS - Indian J Nephrol (2015 Jul-Aug)

(a) Medium- to large-sized monotonous lymphoid cells filling peritubular capillaries. (b) Some of the lymphoid cells are plasmacytoid with coarse chromatin. Inset shows positive staining with CD20
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4495473&req=5

Figure 4: (a) Medium- to large-sized monotonous lymphoid cells filling peritubular capillaries. (b) Some of the lymphoid cells are plasmacytoid with coarse chromatin. Inset shows positive staining with CD20
Mentions: Large- to medium-sized immature lymphoid cells were seen predominantly in the lumen of peritubular capillaries. Cells were CD20+/CD3− with kappa light chain restriction [Figure 4]. CD34 highlighted the peritubular capillaries. There was no evidence of nodal enlargement either on clinical examination or computed tomography imaging of the whole body.

Bottom Line: We observed that renal dysfunction was predominantly a direct effect, that is, lymphomatous invasion.Paraneoplastic glomerulopathic changes occur in the form of MPGN.Proteinuria of >2 g/day correlated with glomerular disease.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Manipal Hospital, Bengaluru, Karnataka, India.

ABSTRACT
Spectrum of causes for renal dysfunction in patients with hematolymphoid malignancy (excluding plasma cell dyscrasia) is varied. A retrospective evaluation of "native" renal biopsies referred to our institute during the period from January 2010 to December 2013 revealed 12 cases. Age ranged between 7 and 69 (median 54.5) years. All patients were males. The neoplasms included non-Hodgkin lymphoma, chronic lymphocytic leukemia, acute lymphoblastic leukemia, Burkitt's lymphoma, intravascular lymphoma, Hodgkin lymphoma and chronic myeloid leukemia. Proteinuria was noted in 66% of the patients (nephrotic range in 5, subnephrotic range in 3). Renal insufficiency was noted in 100% patients. Malignancy-related kidney injury was noted in 75% of the cases. Renal histology showed lymphomatous infiltration (8), membranoproliferative glomerulonephritis (MPGN) (3), intracapillary monoclonal deposit disease (1) and intravascular lymphoma (1). Distribution of lymphomatous infiltration was diffuse in 50% and focal in 50%. We observed that renal dysfunction was predominantly a direct effect, that is, lymphomatous invasion. Paraneoplastic glomerulopathic changes occur in the form of MPGN. Proteinuria of >2 g/day correlated with glomerular disease.

No MeSH data available.


Related in: MedlinePlus