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Impact of an Antimicrobial Stewardship Program on Unnecessary Double Anaerobic Coverage Prescription.

Song YJ, Kim M, Huh S, Lee J, Lee E, Song KH, Kim ES, Kim HB - Infect Chemother (2015)

Bottom Line: To estimate the overall effect of the intervention, we compared the monthly number of patients receiving unnecessary DAC for more than 3 days and the proportion of patients receiving unnecessary DAC for more than 3 days among all patients receiving DAC.The proportion of patients receiving unnecessary DAC for more than 3 days after screening among all patients identified as receiving necessary or unnecessary DAC also decreased by 67.8% in the intervention period from 42.3% to 13.6% (P < 0.001).The multidisciplinary antimicrobial stewardship program with combined methods reduced unnecessary DAC prescription successfully.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacy, Seoul National University Bundang Hospital, Seongnam, Korea.

ABSTRACT

Background: Co-administration of two or more antimicrobials with anti-anaerobic activity is not recommended except in certain circumstances. We therefore conducted an intervention to reduce unnecessary double anaerobic coverage (DAC) prescription.

Materials and methods: The intervention consisted of education using an institutional intranet and prospective audits and feedback provided through collaboration between a pharmacist and an infectious diseases physician in Seoul National University Bundang Hospital, a tertiary hospital in Seongnam, Republic of Korea, in 2013. The study period was 1 year which contained 6 months of pre-intervention period and 6 months of intervention period. To estimate the overall effect of the intervention, we compared the monthly number of patients receiving unnecessary DAC for more than 3 days and the proportion of patients receiving unnecessary DAC for more than 3 days among all patients receiving DAC.

Results: The average monthly number of patients receiving unnecessary DAC for more than 3 days after screening decreased by 73.9% in the intervention period from 26.8 to 7.0. Wilcoxon rank sum test revealed there was a significant statistical difference in the monthly number of patients receiving unnecessary DAC for more than 3 days (P = 0.005). The proportion of patients receiving unnecessary DAC for more than 3 days after screening among all patients identified as receiving necessary or unnecessary DAC also decreased by 67.8% in the intervention period from 42.3% to 13.6% (P < 0.001).

Conclusion: The multidisciplinary antimicrobial stewardship program with combined methods reduced unnecessary DAC prescription successfully.

No MeSH data available.


Related in: MedlinePlus

Patients receiving unnecessary DAC for more than 3 days.DAC, double anaerobic coverage.aThe number of patients receiving unnecessary DAC at screening.bThe proportion of patients receiving unnecessary DAC for more than 3 days among all patients receiving DAC.cThe proportion of patients receiving unnecessary DAC for more than 3 days among patients receiving unnecessary DAC at screening.
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Figure 4: Patients receiving unnecessary DAC for more than 3 days.DAC, double anaerobic coverage.aThe number of patients receiving unnecessary DAC at screening.bThe proportion of patients receiving unnecessary DAC for more than 3 days among all patients receiving DAC.cThe proportion of patients receiving unnecessary DAC for more than 3 days among patients receiving unnecessary DAC at screening.

Mentions: The number of patients receiving unnecessary DAC for more than 3 days was 161 in the pre-intervention period and 42 in the intervention period. The proportion of patients receiving unnecessary DAC for more than 3 days among the patients identified as receiving unnecessary DAC at screening decreased by 48.3% from 77.4% in the pre-intervention period to 40.0% in the intervention period (P = 0.002) (Fig. 4). In other words, changes from day 1 to day 3 increased in the intervention period by 165.5%.


Impact of an Antimicrobial Stewardship Program on Unnecessary Double Anaerobic Coverage Prescription.

Song YJ, Kim M, Huh S, Lee J, Lee E, Song KH, Kim ES, Kim HB - Infect Chemother (2015)

Patients receiving unnecessary DAC for more than 3 days.DAC, double anaerobic coverage.aThe number of patients receiving unnecessary DAC at screening.bThe proportion of patients receiving unnecessary DAC for more than 3 days among all patients receiving DAC.cThe proportion of patients receiving unnecessary DAC for more than 3 days among patients receiving unnecessary DAC at screening.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4495269&req=5

Figure 4: Patients receiving unnecessary DAC for more than 3 days.DAC, double anaerobic coverage.aThe number of patients receiving unnecessary DAC at screening.bThe proportion of patients receiving unnecessary DAC for more than 3 days among all patients receiving DAC.cThe proportion of patients receiving unnecessary DAC for more than 3 days among patients receiving unnecessary DAC at screening.
Mentions: The number of patients receiving unnecessary DAC for more than 3 days was 161 in the pre-intervention period and 42 in the intervention period. The proportion of patients receiving unnecessary DAC for more than 3 days among the patients identified as receiving unnecessary DAC at screening decreased by 48.3% from 77.4% in the pre-intervention period to 40.0% in the intervention period (P = 0.002) (Fig. 4). In other words, changes from day 1 to day 3 increased in the intervention period by 165.5%.

Bottom Line: To estimate the overall effect of the intervention, we compared the monthly number of patients receiving unnecessary DAC for more than 3 days and the proportion of patients receiving unnecessary DAC for more than 3 days among all patients receiving DAC.The proportion of patients receiving unnecessary DAC for more than 3 days after screening among all patients identified as receiving necessary or unnecessary DAC also decreased by 67.8% in the intervention period from 42.3% to 13.6% (P < 0.001).The multidisciplinary antimicrobial stewardship program with combined methods reduced unnecessary DAC prescription successfully.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacy, Seoul National University Bundang Hospital, Seongnam, Korea.

ABSTRACT

Background: Co-administration of two or more antimicrobials with anti-anaerobic activity is not recommended except in certain circumstances. We therefore conducted an intervention to reduce unnecessary double anaerobic coverage (DAC) prescription.

Materials and methods: The intervention consisted of education using an institutional intranet and prospective audits and feedback provided through collaboration between a pharmacist and an infectious diseases physician in Seoul National University Bundang Hospital, a tertiary hospital in Seongnam, Republic of Korea, in 2013. The study period was 1 year which contained 6 months of pre-intervention period and 6 months of intervention period. To estimate the overall effect of the intervention, we compared the monthly number of patients receiving unnecessary DAC for more than 3 days and the proportion of patients receiving unnecessary DAC for more than 3 days among all patients receiving DAC.

Results: The average monthly number of patients receiving unnecessary DAC for more than 3 days after screening decreased by 73.9% in the intervention period from 26.8 to 7.0. Wilcoxon rank sum test revealed there was a significant statistical difference in the monthly number of patients receiving unnecessary DAC for more than 3 days (P = 0.005). The proportion of patients receiving unnecessary DAC for more than 3 days after screening among all patients identified as receiving necessary or unnecessary DAC also decreased by 67.8% in the intervention period from 42.3% to 13.6% (P < 0.001).

Conclusion: The multidisciplinary antimicrobial stewardship program with combined methods reduced unnecessary DAC prescription successfully.

No MeSH data available.


Related in: MedlinePlus