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High-resolution functional MRI at 3 T: 3D/2D echo-planar imaging with optimized physiological noise correction.

Lutti A, Thomas DL, Hutton C, Weiskopf N - Magn Reson Med (2012)

Bottom Line: We extended image-based physiological noise correction from two-dimensional EPI to multishot three-dimensional EPI.The physiological noise correction increased the sensitivity significantly, can be easily applied, and requires simple recordings of pulse and respiration only.The combination of three-dimensional EPI with physiological noise correction provides exceptional sensitivity for 1.5 mm high-resolution fMRI at 3 T, increasing the temporal signal-to-noise ratio by more than 25% compared to two-dimensional EPI.

View Article: PubMed Central - PubMed

Affiliation: Wellcome Trust Centre for Neuroimaging, Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, University College London, London, United Kingdom. a.lutti@ucl.ac.uk

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tSNR maps after physiological correction for the (a) 2D and (b) 3D EPI sequences averaged across subjects. Increase in tSNR due to physiological noise correction for the (c) 2D and (d) 3D EPI acquisition. Increase of tSNR of the 3D EPI sequence over the 2D EPI sequence (e) without and (f) with physiological noise correction. The 3D EPI acquisition resulted in higher tSNR values and also benefited more from physiological noise correction, in particular, in cortical areas (note that green color in figures e and f indicate ∼25% higher tSNR values).
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fig03: tSNR maps after physiological correction for the (a) 2D and (b) 3D EPI sequences averaged across subjects. Increase in tSNR due to physiological noise correction for the (c) 2D and (d) 3D EPI acquisition. Increase of tSNR of the 3D EPI sequence over the 2D EPI sequence (e) without and (f) with physiological noise correction. The 3D EPI acquisition resulted in higher tSNR values and also benefited more from physiological noise correction, in particular, in cortical areas (note that green color in figures e and f indicate ∼25% higher tSNR values).

Mentions: Figure 3a and b shows subject-averaged tSNR maps in Montreal Neurological Institute (MNI) space for the 2D and 3D EPI acquisitions following physiological correction. Higher tSNR values were found for 3D EPI over most brain regions and tissue types. Figure 3c and d shows the increase in tSNR due to physiological correction for 2D and 3D EPI. Figure 3e and f shows comparisons of the tSNR obtained from the 2D and 3D EPI acquisitions before and after physiological correction.


High-resolution functional MRI at 3 T: 3D/2D echo-planar imaging with optimized physiological noise correction.

Lutti A, Thomas DL, Hutton C, Weiskopf N - Magn Reson Med (2012)

tSNR maps after physiological correction for the (a) 2D and (b) 3D EPI sequences averaged across subjects. Increase in tSNR due to physiological noise correction for the (c) 2D and (d) 3D EPI acquisition. Increase of tSNR of the 3D EPI sequence over the 2D EPI sequence (e) without and (f) with physiological noise correction. The 3D EPI acquisition resulted in higher tSNR values and also benefited more from physiological noise correction, in particular, in cortical areas (note that green color in figures e and f indicate ∼25% higher tSNR values).
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Related In: Results  -  Collection

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getmorefigures.php?uid=PMC4495253&req=5

fig03: tSNR maps after physiological correction for the (a) 2D and (b) 3D EPI sequences averaged across subjects. Increase in tSNR due to physiological noise correction for the (c) 2D and (d) 3D EPI acquisition. Increase of tSNR of the 3D EPI sequence over the 2D EPI sequence (e) without and (f) with physiological noise correction. The 3D EPI acquisition resulted in higher tSNR values and also benefited more from physiological noise correction, in particular, in cortical areas (note that green color in figures e and f indicate ∼25% higher tSNR values).
Mentions: Figure 3a and b shows subject-averaged tSNR maps in Montreal Neurological Institute (MNI) space for the 2D and 3D EPI acquisitions following physiological correction. Higher tSNR values were found for 3D EPI over most brain regions and tissue types. Figure 3c and d shows the increase in tSNR due to physiological correction for 2D and 3D EPI. Figure 3e and f shows comparisons of the tSNR obtained from the 2D and 3D EPI acquisitions before and after physiological correction.

Bottom Line: We extended image-based physiological noise correction from two-dimensional EPI to multishot three-dimensional EPI.The physiological noise correction increased the sensitivity significantly, can be easily applied, and requires simple recordings of pulse and respiration only.The combination of three-dimensional EPI with physiological noise correction provides exceptional sensitivity for 1.5 mm high-resolution fMRI at 3 T, increasing the temporal signal-to-noise ratio by more than 25% compared to two-dimensional EPI.

View Article: PubMed Central - PubMed

Affiliation: Wellcome Trust Centre for Neuroimaging, Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, University College London, London, United Kingdom. a.lutti@ucl.ac.uk

Show MeSH
Related in: MedlinePlus