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The effects of age and ganglioside composition on the rate of motor nerve terminal regeneration following antibody-mediated injury in mice.

Rupp A, Cunningham ME, Yao D, Furukawa K, Willison HJ - Synapse (2013)

Bottom Line: Gangliosides are glycosphingolipids highly enriched in neural plasma membranes, where they mediate a diverse range of functions and can act as targets for auto-antibodies present in human immune-mediated neuropathy sera.Both aging and ganglioside-deficiency have been linked to impaired axonal regeneration.Five days later, most NMJs, regardless of age and strain, had recovered their mNTs.

View Article: PubMed Central - PubMed

Affiliation: Neuroimmunology Group, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, G12 8TA, United Kingdom.

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Related in: MedlinePlus

Schematic overview of the synthesis and composition of gangliosides (adapted from Plomp and Willison, 2009). Mice lacking GD3-synthase (α-2,8-sialyltransferase) do not express any b- and c-series gangliosides (orange box), whereas mice lacking GM2-synthase (β1,4-N-acetylgalactosaminyltransferase) do not express any complex gangliosides (green box).
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fig01: Schematic overview of the synthesis and composition of gangliosides (adapted from Plomp and Willison, 2009). Mice lacking GD3-synthase (α-2,8-sialyltransferase) do not express any b- and c-series gangliosides (orange box), whereas mice lacking GM2-synthase (β1,4-N-acetylgalactosaminyltransferase) do not express any complex gangliosides (green box).

Mentions: Gangliosides are glycosphingolipids found within microdomains on cell membranes throughout the body, but enriched in neural tissue (Hamberger and Svennerholm, 1971; Yu et al., 2011). Different gangliosides are distinguished from one another by the number and location of sialic acid residues attached to a neutral sugar backbone ((Svennerholm, 1963; Yu et al., 2011); Fig. 1). The function of gangliosides is very diverse, ranging from neural development, axonal growth, signal transduction, modulation of membrane proteins, node of Ranvier stability and receptor functions, to cell–cell interactions (Plomp and Willison, 2009; Susuki et al., 2007; Zeller and Marchase, 1992). In disease-related roles, they act as targets for toxins and autoantibodies (autoAbs).


The effects of age and ganglioside composition on the rate of motor nerve terminal regeneration following antibody-mediated injury in mice.

Rupp A, Cunningham ME, Yao D, Furukawa K, Willison HJ - Synapse (2013)

Schematic overview of the synthesis and composition of gangliosides (adapted from Plomp and Willison, 2009). Mice lacking GD3-synthase (α-2,8-sialyltransferase) do not express any b- and c-series gangliosides (orange box), whereas mice lacking GM2-synthase (β1,4-N-acetylgalactosaminyltransferase) do not express any complex gangliosides (green box).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4495252&req=5

fig01: Schematic overview of the synthesis and composition of gangliosides (adapted from Plomp and Willison, 2009). Mice lacking GD3-synthase (α-2,8-sialyltransferase) do not express any b- and c-series gangliosides (orange box), whereas mice lacking GM2-synthase (β1,4-N-acetylgalactosaminyltransferase) do not express any complex gangliosides (green box).
Mentions: Gangliosides are glycosphingolipids found within microdomains on cell membranes throughout the body, but enriched in neural tissue (Hamberger and Svennerholm, 1971; Yu et al., 2011). Different gangliosides are distinguished from one another by the number and location of sialic acid residues attached to a neutral sugar backbone ((Svennerholm, 1963; Yu et al., 2011); Fig. 1). The function of gangliosides is very diverse, ranging from neural development, axonal growth, signal transduction, modulation of membrane proteins, node of Ranvier stability and receptor functions, to cell–cell interactions (Plomp and Willison, 2009; Susuki et al., 2007; Zeller and Marchase, 1992). In disease-related roles, they act as targets for toxins and autoantibodies (autoAbs).

Bottom Line: Gangliosides are glycosphingolipids highly enriched in neural plasma membranes, where they mediate a diverse range of functions and can act as targets for auto-antibodies present in human immune-mediated neuropathy sera.Both aging and ganglioside-deficiency have been linked to impaired axonal regeneration.Five days later, most NMJs, regardless of age and strain, had recovered their mNTs.

View Article: PubMed Central - PubMed

Affiliation: Neuroimmunology Group, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, G12 8TA, United Kingdom.

Show MeSH
Related in: MedlinePlus