The effects of age and ganglioside composition on the rate of motor nerve terminal regeneration following antibody-mediated injury in mice.
Bottom Line: Gangliosides are glycosphingolipids highly enriched in neural plasma membranes, where they mediate a diverse range of functions and can act as targets for auto-antibodies present in human immune-mediated neuropathy sera.Both aging and ganglioside-deficiency have been linked to impaired axonal regeneration.Five days later, most NMJs, regardless of age and strain, had recovered their mNTs.
Affiliation: Neuroimmunology Group, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, G12 8TA, United Kingdom.Show MeSH
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Mentions: Gangliosides are glycosphingolipids found within microdomains on cell membranes throughout the body, but enriched in neural tissue (Hamberger and Svennerholm, 1971; Yu et al., 2011). Different gangliosides are distinguished from one another by the number and location of sialic acid residues attached to a neutral sugar backbone ((Svennerholm, 1963; Yu et al., 2011); Fig. 1). The function of gangliosides is very diverse, ranging from neural development, axonal growth, signal transduction, modulation of membrane proteins, node of Ranvier stability and receptor functions, to cell–cell interactions (Plomp and Willison, 2009; Susuki et al., 2007; Zeller and Marchase, 1992). In disease-related roles, they act as targets for toxins and autoantibodies (autoAbs).
Affiliation: Neuroimmunology Group, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, G12 8TA, United Kingdom.