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Dermatomyositis presenting as a paraneoplastic syndrome with resolution of symptoms following surgical management of underlying breast malignancy.

Luu X, Leonard S, Joseph KA - J Surg Case Rep (2015)

Bottom Line: Dermatomyositis (DM) is an uncommon idiopathic inflammatory myopathy that can manifest as a paraneoplastic syndrome of an underlying malignancy.The patient's rash and muscle weakness progressed during the workup of her breast cancer, while she was already started on medical treatment of these symptoms with oral prednisone.Our case report describes the rapid progression and regression of her symptoms emphasizing the benefit of early diagnosis and treatment of DM as well as the underlying breast cancer.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Surgery, Bellevue Medical Center, New York University School of Medicine, New York, NY, USA.

No MeSH data available.


Related in: MedlinePlus

Low power view of the left breast core biopsy (A). High power view of the left breast core biopsy (B).
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RJV075F4: Low power view of the left breast core biopsy (A). High power view of the left breast core biopsy (B).

Mentions: The patient is a 47-year-old Polish premenopausal female who presented with complaints of a non-tender palpable left breast mass for 4 months at an outside institution. She underwent a diagnostic mammogram and ultrasound that reported a 2-cm irregular, hypoechoic mass at 12 o'clock. The mass had indistinct borders on ultrasound (Figs. 1,2). Bilateral breast MRI revealed no disease in either axilla or the right breast. There was a 2.2-cm enhancing mass in the left breast at 12:00 that was consistent with the patient's biopsy-proven malignancy (Fig. 3). Upon examination in the Breast Surgery clinic, she underwent a core needle biopsy, which revealed a poorly differentiated triple-negative invasive ductal carcinoma (Fig. 4).Figure 1:


Dermatomyositis presenting as a paraneoplastic syndrome with resolution of symptoms following surgical management of underlying breast malignancy.

Luu X, Leonard S, Joseph KA - J Surg Case Rep (2015)

Low power view of the left breast core biopsy (A). High power view of the left breast core biopsy (B).
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4495251&req=5

RJV075F4: Low power view of the left breast core biopsy (A). High power view of the left breast core biopsy (B).
Mentions: The patient is a 47-year-old Polish premenopausal female who presented with complaints of a non-tender palpable left breast mass for 4 months at an outside institution. She underwent a diagnostic mammogram and ultrasound that reported a 2-cm irregular, hypoechoic mass at 12 o'clock. The mass had indistinct borders on ultrasound (Figs. 1,2). Bilateral breast MRI revealed no disease in either axilla or the right breast. There was a 2.2-cm enhancing mass in the left breast at 12:00 that was consistent with the patient's biopsy-proven malignancy (Fig. 3). Upon examination in the Breast Surgery clinic, she underwent a core needle biopsy, which revealed a poorly differentiated triple-negative invasive ductal carcinoma (Fig. 4).Figure 1:

Bottom Line: Dermatomyositis (DM) is an uncommon idiopathic inflammatory myopathy that can manifest as a paraneoplastic syndrome of an underlying malignancy.The patient's rash and muscle weakness progressed during the workup of her breast cancer, while she was already started on medical treatment of these symptoms with oral prednisone.Our case report describes the rapid progression and regression of her symptoms emphasizing the benefit of early diagnosis and treatment of DM as well as the underlying breast cancer.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Surgery, Bellevue Medical Center, New York University School of Medicine, New York, NY, USA.

No MeSH data available.


Related in: MedlinePlus