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Characteristics of Small Bowel Polyps Detected in Cowden Syndrome by Capsule Endoscopy.

Saito K, Nomura E, Sasaki Y, Abe Y, Kanno N, Mizumoto N, Shibuya R, Sakuta K, Yagi M, Yoshizawa K, Iwano D, Sato T, Nishise S, Ueno Y - Case Rep Gastrointest Med (2015)

Bottom Line: Cowden syndrome is an uncommon, autosomal dominant disease characterized by multiple hamartomas and hyperplastic lesions in the skin, mucous membrane, brain, breast, thyroid, and gastrointestinal tract.Hamartomatous polyps occur throughout the gastrointestinal tract, the most common sites being the stomach, colon, esophagus, and duodenum.The small bowel polyps of Cowden syndrome frequently occur at the oral end of the small bowel, especially in the duodenum and jejunum, and their color is similar to that of the surrounding mucosa; additionally, the polyps are relatively small (2-5 mm).

View Article: PubMed Central - PubMed

Affiliation: Department of Gastroenterology, Faculty of Medicine, Yamagata University, 2-2-2 Iida-Nishi, Yamagata 990-9585, Japan.

ABSTRACT
Cowden syndrome is an uncommon, autosomal dominant disease characterized by multiple hamartomas and hyperplastic lesions in the skin, mucous membrane, brain, breast, thyroid, and gastrointestinal tract. About 30% of Cowden syndrome cases are reportedly complicated by malignant diseases. Hamartomatous polyps occur throughout the gastrointestinal tract, the most common sites being the stomach, colon, esophagus, and duodenum. Small bowel polyps can occur in Cowden syndrome; however, they are difficult to detect by conventional examination, including double-contrast X-ray study. Here, we report three cases of Cowden syndrome with small bowel polyps, which were detected by capsule endoscopy. The small bowel polyps of Cowden syndrome frequently occur at the oral end of the small bowel, especially in the duodenum and jejunum, and their color is similar to that of the surrounding mucosa; additionally, the polyps are relatively small (2-5 mm). Capsule endoscopy is useful for detecting small bowel polyps in Cowden syndrome.

No MeSH data available.


Related in: MedlinePlus

Capsule endoscopy revealed polyps of normal color in the jejunum.
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fig2: Capsule endoscopy revealed polyps of normal color in the jejunum.

Mentions: A 60-year-old woman was referred to our hospital for further examination of multiple gastric polyps. She had a past history of breast fibroadenoma and thyroid goiter. She had oral papilloma, esophageal glycogenic acanthosis, and polyposis in the stomach, duodenum, and colon as observed by endoscopic examination. Histological assessment of the biopsy specimens revealed that the gastric and colonic polyps were hamartomatous, and she was diagnosed with Cowden syndrome. CE revealed many polyps of normal color that ranged from 2 to 5 mm in size in the small bowel (Figure 2). These polyps were sparse but were more frequently observed in the jejunum.


Characteristics of Small Bowel Polyps Detected in Cowden Syndrome by Capsule Endoscopy.

Saito K, Nomura E, Sasaki Y, Abe Y, Kanno N, Mizumoto N, Shibuya R, Sakuta K, Yagi M, Yoshizawa K, Iwano D, Sato T, Nishise S, Ueno Y - Case Rep Gastrointest Med (2015)

Capsule endoscopy revealed polyps of normal color in the jejunum.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4495180&req=5

fig2: Capsule endoscopy revealed polyps of normal color in the jejunum.
Mentions: A 60-year-old woman was referred to our hospital for further examination of multiple gastric polyps. She had a past history of breast fibroadenoma and thyroid goiter. She had oral papilloma, esophageal glycogenic acanthosis, and polyposis in the stomach, duodenum, and colon as observed by endoscopic examination. Histological assessment of the biopsy specimens revealed that the gastric and colonic polyps were hamartomatous, and she was diagnosed with Cowden syndrome. CE revealed many polyps of normal color that ranged from 2 to 5 mm in size in the small bowel (Figure 2). These polyps were sparse but were more frequently observed in the jejunum.

Bottom Line: Cowden syndrome is an uncommon, autosomal dominant disease characterized by multiple hamartomas and hyperplastic lesions in the skin, mucous membrane, brain, breast, thyroid, and gastrointestinal tract.Hamartomatous polyps occur throughout the gastrointestinal tract, the most common sites being the stomach, colon, esophagus, and duodenum.The small bowel polyps of Cowden syndrome frequently occur at the oral end of the small bowel, especially in the duodenum and jejunum, and their color is similar to that of the surrounding mucosa; additionally, the polyps are relatively small (2-5 mm).

View Article: PubMed Central - PubMed

Affiliation: Department of Gastroenterology, Faculty of Medicine, Yamagata University, 2-2-2 Iida-Nishi, Yamagata 990-9585, Japan.

ABSTRACT
Cowden syndrome is an uncommon, autosomal dominant disease characterized by multiple hamartomas and hyperplastic lesions in the skin, mucous membrane, brain, breast, thyroid, and gastrointestinal tract. About 30% of Cowden syndrome cases are reportedly complicated by malignant diseases. Hamartomatous polyps occur throughout the gastrointestinal tract, the most common sites being the stomach, colon, esophagus, and duodenum. Small bowel polyps can occur in Cowden syndrome; however, they are difficult to detect by conventional examination, including double-contrast X-ray study. Here, we report three cases of Cowden syndrome with small bowel polyps, which were detected by capsule endoscopy. The small bowel polyps of Cowden syndrome frequently occur at the oral end of the small bowel, especially in the duodenum and jejunum, and their color is similar to that of the surrounding mucosa; additionally, the polyps are relatively small (2-5 mm). Capsule endoscopy is useful for detecting small bowel polyps in Cowden syndrome.

No MeSH data available.


Related in: MedlinePlus