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Mucoepidermoid carcinoma in Warthin tumor of the parotid gland.

Smółka W, Markowski J, Piotrowska-Seweryn A, Paleń P, Dobrosz Z, Dziubdziela W - Arch Med Sci (2015)

View Article: PubMed Central - PubMed

Affiliation: Department of Laryngology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland.

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Neoplasms of salivary glands are responsible for ca. 3–5% of head and neck tumors, and they usually occur in the parotid gland (80%) as benign tumors (80%)... A lot of similarities in negative immunohistochemical findings, mainly concerning CK20, p16, MUC-2, HER-2, lysozyme, racemase, S-100, SMA and actin, were reported... No metastases in the lymph nodes were found... Mucoepidermoid carcinoma in WT of the parotid gland seems to be a rare entity, and it is mentioned by several authors... In our study Warthin tumor with MEC of the left parotid gland was diagnosed 1 year after the patient underwent superficial parotidectomy due to WT of the contralateral parotid gland... According to Mohapatra et al., epithelial neoplastic tissue can appear in WT under the following types: 1) co-existing separate neoplasm, e.g. pleomorphic adenoma – the most common type; 2) metastatic tissue of another head and neck carcinoma; 3) primary carcinoma arising in the epithelial component... The most common metastases to the parotid gland originate from head and neck squamous cell carcinomas, lung, breast and colon cancer... The only differences were observed when analyzing p63 and Ki-67... However, these antibodies are often used to differentiate between benign and malignant tissues, as can be found in our results (Figure 4)... Finally, molecular analysis of MEC, especially those with synchronous Warthin tumor, is a matter of many recent studies... Namely, it has been found that MEC can be associated with recurring chromosomal translocation t(11;19) (q21;p13), which results in the fusion transcript MECT1-MAML2... Nevertheless, the authors hope to present a complementary explanation soon... In conclusion, mucoepidermoid carcinoma in WT is a rare entity... However, thanks to rapidly developing molecular studies, there is a hope for establishment of a definite explanation of its origin, which might result in easy diagnosis of similar cases in the future.

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p63 nuclear staining in abluminal cells of WT. No staining in carcinoma cells
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Figure 0004: p63 nuclear staining in abluminal cells of WT. No staining in carcinoma cells

Mentions: Morphological examination of the material showed carcinomatous infiltration in the adjacent lipomatous tissue and a WT with a malignant transformation into MEC (Figure 1). The epithelial component formed of double-layered oxyphilic tubules in close association with high-grade invasive carcinoma with partially solid, partially tubular appearance was observed (Figure 2). Immunohistochemical profile of the WT and MEC arising within it was revealed thanks to 26 immunohistochemical examinations (Table I). A great similarity among cytokeratin antibodies, especially CK7 and CK19, was found (Figure 3). p63 nuclear staining acted as a differentiating examination between carcinoma cells and WT cells (Figure 4). Positive reactions in both tissues were found when analyzing E-cadherin, MUC-1 and calponin. A lot of similarities in negative immunohistochemical findings, mainly concerning CK20, p16, MUC-2, HER-2, lysozyme, racemase, S-100, SMA and actin, were reported.


Mucoepidermoid carcinoma in Warthin tumor of the parotid gland.

Smółka W, Markowski J, Piotrowska-Seweryn A, Paleń P, Dobrosz Z, Dziubdziela W - Arch Med Sci (2015)

p63 nuclear staining in abluminal cells of WT. No staining in carcinoma cells
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4495166&req=5

Figure 0004: p63 nuclear staining in abluminal cells of WT. No staining in carcinoma cells
Mentions: Morphological examination of the material showed carcinomatous infiltration in the adjacent lipomatous tissue and a WT with a malignant transformation into MEC (Figure 1). The epithelial component formed of double-layered oxyphilic tubules in close association with high-grade invasive carcinoma with partially solid, partially tubular appearance was observed (Figure 2). Immunohistochemical profile of the WT and MEC arising within it was revealed thanks to 26 immunohistochemical examinations (Table I). A great similarity among cytokeratin antibodies, especially CK7 and CK19, was found (Figure 3). p63 nuclear staining acted as a differentiating examination between carcinoma cells and WT cells (Figure 4). Positive reactions in both tissues were found when analyzing E-cadherin, MUC-1 and calponin. A lot of similarities in negative immunohistochemical findings, mainly concerning CK20, p16, MUC-2, HER-2, lysozyme, racemase, S-100, SMA and actin, were reported.

View Article: PubMed Central - PubMed

Affiliation: Department of Laryngology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland.

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Neoplasms of salivary glands are responsible for ca. 3–5% of head and neck tumors, and they usually occur in the parotid gland (80%) as benign tumors (80%)... A lot of similarities in negative immunohistochemical findings, mainly concerning CK20, p16, MUC-2, HER-2, lysozyme, racemase, S-100, SMA and actin, were reported... No metastases in the lymph nodes were found... Mucoepidermoid carcinoma in WT of the parotid gland seems to be a rare entity, and it is mentioned by several authors... In our study Warthin tumor with MEC of the left parotid gland was diagnosed 1 year after the patient underwent superficial parotidectomy due to WT of the contralateral parotid gland... According to Mohapatra et al., epithelial neoplastic tissue can appear in WT under the following types: 1) co-existing separate neoplasm, e.g. pleomorphic adenoma – the most common type; 2) metastatic tissue of another head and neck carcinoma; 3) primary carcinoma arising in the epithelial component... The most common metastases to the parotid gland originate from head and neck squamous cell carcinomas, lung, breast and colon cancer... The only differences were observed when analyzing p63 and Ki-67... However, these antibodies are often used to differentiate between benign and malignant tissues, as can be found in our results (Figure 4)... Finally, molecular analysis of MEC, especially those with synchronous Warthin tumor, is a matter of many recent studies... Namely, it has been found that MEC can be associated with recurring chromosomal translocation t(11;19) (q21;p13), which results in the fusion transcript MECT1-MAML2... Nevertheless, the authors hope to present a complementary explanation soon... In conclusion, mucoepidermoid carcinoma in WT is a rare entity... However, thanks to rapidly developing molecular studies, there is a hope for establishment of a definite explanation of its origin, which might result in easy diagnosis of similar cases in the future.

No MeSH data available.