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Papillary renal cell carcinoma and collecting duct carcinoma combination. A case report and review of synchronous renal cell carcinoma subtypes in the same kidney.

Arık D, Açıkalın MF, Can C - Arch Med Sci (2015)

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Faculty of Medicine, Eskisehir Osmangazi University, Eskişehir, Turkey.

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Collecting duct carcinoma (CDC), also known as Bellini duct carcinoma, is a rare neoplasm comprising less than 1% of renal epithelial tumors... Papillary renal cell carcinoma (PRCC) comprises 10% of renal cell carcinomas (RCC) and has distinct cytogenetic and molecular features... The solid component was diagnosed as CDC with nodal metastasis, renal capsular and pelvic invasion... The cystic component was diagnosed as type 2 PRCC... Synchronous tumors in the same kidney is a rare occurrence... The RCC cases associated with angiomyolipoma, oncocytoma and TCC were presented as a small series in the literature... Cho et al... reported a case with two different clonal expansions in one nodule, of unclassified RCC and CDC as nodule-in-nodule morphology with different karyotypic alterations and immunohistochemical results... Gong et al... reported that the CRCC component showed both CDC differentiation and sarcomatoid dedifferentiation, and concluded that the tumor was monoclonal because in metastatic focuses all three elements were seen... Our case is unique because this is the first case of synchronous PRCC and CDC seen as a single mass... Previously reported PRCC and CDC combinations were completely separate tumors at different locations in the same kidney... In our case, the CDC is expected to behave in an aggressive way... Infiltration and encircling of the PRCC by the CDC may form the morphology what we have described.

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Related in: MedlinePlus

Collecting duct carcinoma component is positive with low molecular weight keratin (A + E1, 100×)
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Figure 0004: Collecting duct carcinoma component is positive with low molecular weight keratin (A + E1, 100×)


Papillary renal cell carcinoma and collecting duct carcinoma combination. A case report and review of synchronous renal cell carcinoma subtypes in the same kidney.

Arık D, Açıkalın MF, Can C - Arch Med Sci (2015)

Collecting duct carcinoma component is positive with low molecular weight keratin (A + E1, 100×)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4495165&req=5

Figure 0004: Collecting duct carcinoma component is positive with low molecular weight keratin (A + E1, 100×)

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Faculty of Medicine, Eskisehir Osmangazi University, Eskişehir, Turkey.

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Collecting duct carcinoma (CDC), also known as Bellini duct carcinoma, is a rare neoplasm comprising less than 1% of renal epithelial tumors... Papillary renal cell carcinoma (PRCC) comprises 10% of renal cell carcinomas (RCC) and has distinct cytogenetic and molecular features... The solid component was diagnosed as CDC with nodal metastasis, renal capsular and pelvic invasion... The cystic component was diagnosed as type 2 PRCC... Synchronous tumors in the same kidney is a rare occurrence... The RCC cases associated with angiomyolipoma, oncocytoma and TCC were presented as a small series in the literature... Cho et al... reported a case with two different clonal expansions in one nodule, of unclassified RCC and CDC as nodule-in-nodule morphology with different karyotypic alterations and immunohistochemical results... Gong et al... reported that the CRCC component showed both CDC differentiation and sarcomatoid dedifferentiation, and concluded that the tumor was monoclonal because in metastatic focuses all three elements were seen... Our case is unique because this is the first case of synchronous PRCC and CDC seen as a single mass... Previously reported PRCC and CDC combinations were completely separate tumors at different locations in the same kidney... In our case, the CDC is expected to behave in an aggressive way... Infiltration and encircling of the PRCC by the CDC may form the morphology what we have described.

No MeSH data available.


Related in: MedlinePlus