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Vasoconstrictive effects of levobupivacaine on the basilar artery in the rabbit.

Ergil J, Kertmen H, Sayın M, Gürer B, Yılmaz ER, Özkan D, Arıkök AT, Kanat MA, Şekerci Z - Arch Med Sci (2015)

Bottom Line: Both 0.125% and 0.25% levobupivacaine infusion caused significant vasoconstriction.Vasoconstriction was more significant for the 0.125% concentration.The results of this study indicated that both 0.125% and 0.25% concentrations of levobupivacaine caused significant vasoconstriction of the basilar artery when administered into the subarachnoid space.

View Article: PubMed Central - PubMed

Affiliation: Anesthesiology Department, Diskapi Yildirim Beyazit Education and Research Hospital, Ministry of Health, Ankara, Turkey.

ABSTRACT

Introduction: Spinal anesthesia is a widely used technique of the modern practice of anesthesia. Spinal cord ischemia is a rare but catastrophic complication of spinal anesthesia which may be caused by a direct vasoconstrictive effect of the local anesthetic. Although the vasoconstrictive effects of levobupivacaine have been widely studied, the vasoconstrictive effects of this drug on the intradural arteries have never been studied. The aim of this study is to evaluate whether levobupivacaine has vasoconstrictive effects on the basilar artery in rabbits.

Material and methods: Thirty male New Zealand white rabbits were divided randomly into three groups of ten rabbits each: group 1 (control); group 2 (0.125% levobupivacaine); group 3 (0.25% levobupivacaine). The cisterna magna was punctured as described below, then 1 ml of saline or 0.125% or 0.25% levobupivacaine was injected into the cisterna magna in 10 min by an infusion pump in groups 1, 2 and 3 respectively. All animals were euthanized by perfusion-fixation 30 min after the procedure. The luminal area and the size of the cross-sectional area for each basilar artery were measured.

Results: Both 0.125% and 0.25% levobupivacaine infusion caused significant vasoconstriction. Vasoconstriction was more significant for the 0.125% concentration.

Conclusions: The results of this study indicated that both 0.125% and 0.25% concentrations of levobupivacaine caused significant vasoconstriction of the basilar artery when administered into the subarachnoid space. This may constitute proof that subarachnoid administration of levobupivacaine may diminish the spinal cord blood flow, causing ischemia.

No MeSH data available.


Related in: MedlinePlus

Mean basilar artery wall thicknesses of the study groupsValues are expressed as mean ± SD.
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Figure 0004: Mean basilar artery wall thicknesses of the study groupsValues are expressed as mean ± SD.

Mentions: The mean value of the basilar artery wall thickness was 25.4 ±3.4 μm in the control group. In the low-dose and the high-dose groups the mean value of the basilar artery wall thicknesses was 45.2 ±2.3 μm and 37.0 ±3.2 μm respectively. When compared with the control group, the increase in the mean basilar artery wall thickness was statistically significant in both low-dose and high-dose groups (p < 0.001 for both). When the low-dose and the high-dose groups were compared to each other, the difference was also statistically significant (p < 0.001) (Figure 4). The arterial wall thickness values are shown in Table IV.


Vasoconstrictive effects of levobupivacaine on the basilar artery in the rabbit.

Ergil J, Kertmen H, Sayın M, Gürer B, Yılmaz ER, Özkan D, Arıkök AT, Kanat MA, Şekerci Z - Arch Med Sci (2015)

Mean basilar artery wall thicknesses of the study groupsValues are expressed as mean ± SD.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4495161&req=5

Figure 0004: Mean basilar artery wall thicknesses of the study groupsValues are expressed as mean ± SD.
Mentions: The mean value of the basilar artery wall thickness was 25.4 ±3.4 μm in the control group. In the low-dose and the high-dose groups the mean value of the basilar artery wall thicknesses was 45.2 ±2.3 μm and 37.0 ±3.2 μm respectively. When compared with the control group, the increase in the mean basilar artery wall thickness was statistically significant in both low-dose and high-dose groups (p < 0.001 for both). When the low-dose and the high-dose groups were compared to each other, the difference was also statistically significant (p < 0.001) (Figure 4). The arterial wall thickness values are shown in Table IV.

Bottom Line: Both 0.125% and 0.25% levobupivacaine infusion caused significant vasoconstriction.Vasoconstriction was more significant for the 0.125% concentration.The results of this study indicated that both 0.125% and 0.25% concentrations of levobupivacaine caused significant vasoconstriction of the basilar artery when administered into the subarachnoid space.

View Article: PubMed Central - PubMed

Affiliation: Anesthesiology Department, Diskapi Yildirim Beyazit Education and Research Hospital, Ministry of Health, Ankara, Turkey.

ABSTRACT

Introduction: Spinal anesthesia is a widely used technique of the modern practice of anesthesia. Spinal cord ischemia is a rare but catastrophic complication of spinal anesthesia which may be caused by a direct vasoconstrictive effect of the local anesthetic. Although the vasoconstrictive effects of levobupivacaine have been widely studied, the vasoconstrictive effects of this drug on the intradural arteries have never been studied. The aim of this study is to evaluate whether levobupivacaine has vasoconstrictive effects on the basilar artery in rabbits.

Material and methods: Thirty male New Zealand white rabbits were divided randomly into three groups of ten rabbits each: group 1 (control); group 2 (0.125% levobupivacaine); group 3 (0.25% levobupivacaine). The cisterna magna was punctured as described below, then 1 ml of saline or 0.125% or 0.25% levobupivacaine was injected into the cisterna magna in 10 min by an infusion pump in groups 1, 2 and 3 respectively. All animals were euthanized by perfusion-fixation 30 min after the procedure. The luminal area and the size of the cross-sectional area for each basilar artery were measured.

Results: Both 0.125% and 0.25% levobupivacaine infusion caused significant vasoconstriction. Vasoconstriction was more significant for the 0.125% concentration.

Conclusions: The results of this study indicated that both 0.125% and 0.25% concentrations of levobupivacaine caused significant vasoconstriction of the basilar artery when administered into the subarachnoid space. This may constitute proof that subarachnoid administration of levobupivacaine may diminish the spinal cord blood flow, causing ischemia.

No MeSH data available.


Related in: MedlinePlus