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Association between inflammatory biomarkers and thin-cap fibroatheroma detected by optical coherence tomography in patients with coronary heart disease.

Koyama K, Yoneyama K, Mitarai T, Ishibashi Y, Takahashi E, Kongoji K, Harada T, Akashi YJ - Arch Med Sci (2015)

Bottom Line: Receiver operating characteristic curve analysis confirmed that IL-6, compared to hs-CRP, has a higher area under the curve for predicting TCFA (0.783 vs. 0.715, respectively).Peripheral blood levels of both hs-CRP and IL-6 were associated with TCFAs, as detected by OCT.Moreover, IL-6 has a higher potential than hs-CRP for predicting TCFA.

View Article: PubMed Central - PubMed

Affiliation: Division of Cardiology, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan.

ABSTRACT

Introduction: The relationship between plaque morphology detected by optical coherence tomography (OCT) and inflammatory biomarkers is not well known.

Material and methods: This study included 47 patients with ischemic heart disease (22 patients with acute coronary syndrome and 25 patients with effort angina pectoris) who underwent percutaneous coronary intervention (PCI). Before PCI, peripheral blood levels of the inflammatory biomarkers high-sensitivity C-reactive protein (hs-CRP) and interleukin-6 (IL-6) were measured. The OCT can detect thin-cap fibroatheroma (TCFA), a lesion with high potential for adverse cardiac events. We investigated the relationships between TCFAs in culprit lesions detected by OCT and the peripheral blood levels of these biomarkers.

Results: We observed 12 lesions detected as TCFAs. The natural logs of hs-CRP and IL-6 levels in the TCFA group were higher than those in the non-TCFA group (hs-CRP 0.87 (-0.96 to 0.87) vs. -0.47 (-0.92 to 0.30) mg/l, p = 0.027; and IL-6 1.63 (0.63-3.23) vs. 0.53 (-0.21 to 1.05) pg/dl, p = 0.005, respectively). In multivariate logistic regression analysis, log IL-6 was an independent predictor for TCFA detected by OCT (log IL-6, 0.970 pg/dl, p = 0.023). Receiver operating characteristic curve analysis confirmed that IL-6, compared to hs-CRP, has a higher area under the curve for predicting TCFA (0.783 vs. 0.715, respectively).

Conclusions: Peripheral blood levels of both hs-CRP and IL-6 were associated with TCFAs, as detected by OCT. Moreover, IL-6 has a higher potential than hs-CRP for predicting TCFA.

No MeSH data available.


Related in: MedlinePlus

Box plots of natural log white blood count, hs-CRP and IL-6. Patients who had thin-capped fibroatheroma (TCFA) plaques in culprit lesion had higher concentrations of log hs-CRP and IL-6. There was no difference in log white blood count between patients who had TCFA and non-TCFA in the culprit lesion
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Figure 0003: Box plots of natural log white blood count, hs-CRP and IL-6. Patients who had thin-capped fibroatheroma (TCFA) plaques in culprit lesion had higher concentrations of log hs-CRP and IL-6. There was no difference in log white blood count between patients who had TCFA and non-TCFA in the culprit lesion

Mentions: Because 3 (2 ACS patients and 1 SAP patient) of the 50 CVD patients were excluded owing to poor OCT imaging quality, we finally investigated 47 patients. Baseline characteristics of the patients are shown in Table I. Mean age was 67 ±11 years, and most of the patients were men. There were no significant differences in medical history, use of medicines, or cholesterol and hemoglobin A1c levels between the TCFA and non-TCFA groups. The incidence of AMI was higher in the TCFA group than in the non-TCFA group. Peripheral blood levels of hs-CRP and IL-6 in the TCFA group were relatively higher than those in the non-TFCA group (hs-CRP 2.62 (0.55–11.40) vs. 0.63 (0.40–1.35) mg/dl, p = 0.027; IL-6 5.13 (1.92–26.18) vs. 1.70 (0.80–1.35) pg/dl, p = 0.004, respectively) (Table I, Figure 3).


Association between inflammatory biomarkers and thin-cap fibroatheroma detected by optical coherence tomography in patients with coronary heart disease.

Koyama K, Yoneyama K, Mitarai T, Ishibashi Y, Takahashi E, Kongoji K, Harada T, Akashi YJ - Arch Med Sci (2015)

Box plots of natural log white blood count, hs-CRP and IL-6. Patients who had thin-capped fibroatheroma (TCFA) plaques in culprit lesion had higher concentrations of log hs-CRP and IL-6. There was no difference in log white blood count between patients who had TCFA and non-TCFA in the culprit lesion
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4495146&req=5

Figure 0003: Box plots of natural log white blood count, hs-CRP and IL-6. Patients who had thin-capped fibroatheroma (TCFA) plaques in culprit lesion had higher concentrations of log hs-CRP and IL-6. There was no difference in log white blood count between patients who had TCFA and non-TCFA in the culprit lesion
Mentions: Because 3 (2 ACS patients and 1 SAP patient) of the 50 CVD patients were excluded owing to poor OCT imaging quality, we finally investigated 47 patients. Baseline characteristics of the patients are shown in Table I. Mean age was 67 ±11 years, and most of the patients were men. There were no significant differences in medical history, use of medicines, or cholesterol and hemoglobin A1c levels between the TCFA and non-TCFA groups. The incidence of AMI was higher in the TCFA group than in the non-TCFA group. Peripheral blood levels of hs-CRP and IL-6 in the TCFA group were relatively higher than those in the non-TFCA group (hs-CRP 2.62 (0.55–11.40) vs. 0.63 (0.40–1.35) mg/dl, p = 0.027; IL-6 5.13 (1.92–26.18) vs. 1.70 (0.80–1.35) pg/dl, p = 0.004, respectively) (Table I, Figure 3).

Bottom Line: Receiver operating characteristic curve analysis confirmed that IL-6, compared to hs-CRP, has a higher area under the curve for predicting TCFA (0.783 vs. 0.715, respectively).Peripheral blood levels of both hs-CRP and IL-6 were associated with TCFAs, as detected by OCT.Moreover, IL-6 has a higher potential than hs-CRP for predicting TCFA.

View Article: PubMed Central - PubMed

Affiliation: Division of Cardiology, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan.

ABSTRACT

Introduction: The relationship between plaque morphology detected by optical coherence tomography (OCT) and inflammatory biomarkers is not well known.

Material and methods: This study included 47 patients with ischemic heart disease (22 patients with acute coronary syndrome and 25 patients with effort angina pectoris) who underwent percutaneous coronary intervention (PCI). Before PCI, peripheral blood levels of the inflammatory biomarkers high-sensitivity C-reactive protein (hs-CRP) and interleukin-6 (IL-6) were measured. The OCT can detect thin-cap fibroatheroma (TCFA), a lesion with high potential for adverse cardiac events. We investigated the relationships between TCFAs in culprit lesions detected by OCT and the peripheral blood levels of these biomarkers.

Results: We observed 12 lesions detected as TCFAs. The natural logs of hs-CRP and IL-6 levels in the TCFA group were higher than those in the non-TCFA group (hs-CRP 0.87 (-0.96 to 0.87) vs. -0.47 (-0.92 to 0.30) mg/l, p = 0.027; and IL-6 1.63 (0.63-3.23) vs. 0.53 (-0.21 to 1.05) pg/dl, p = 0.005, respectively). In multivariate logistic regression analysis, log IL-6 was an independent predictor for TCFA detected by OCT (log IL-6, 0.970 pg/dl, p = 0.023). Receiver operating characteristic curve analysis confirmed that IL-6, compared to hs-CRP, has a higher area under the curve for predicting TCFA (0.783 vs. 0.715, respectively).

Conclusions: Peripheral blood levels of both hs-CRP and IL-6 were associated with TCFAs, as detected by OCT. Moreover, IL-6 has a higher potential than hs-CRP for predicting TCFA.

No MeSH data available.


Related in: MedlinePlus