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Synthesis of a new series of biologically interesting 6'-chloro-1',1'-dioxospiro[4H-benzo[d][1,3,7]oxadiazocine-4,3'(2'H)-[1,4,2]benzodithiazine]-2,6(1H,5H)dione derivatives.

Brzozowski Z, Żołnowska B, Sławiński J - Monatsh. Chem. (2013)

Bottom Line: A series of 6'-chloro-1',1'-dioxospiro[4H-benzo[d][1,3,7]oxadiazocine-4,3'(2'H)-[1,4,2]benzodithiazine]-2,6(1H,5H)dione derivatives have been synthesized from isatoic anhydride and 3-(R(2)-amino)-1,4,2-benzodithiazine 1,1-dioxides.Some synthetic limitations are discussed on the basis of quantum chemical calculations performed by use of the Hartree-Fock method.

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Affiliation: Department of Organic Chemistry, Medical University of Gdańsk, Gen. J. Hallera Str. 107, 80416 Gdańsk, Poland.

ABSTRACT

Abstract: A series of 6'-chloro-1',1'-dioxospiro[4H-benzo[d][1,3,7]oxadiazocine-4,3'(2'H)-[1,4,2]benzodithiazine]-2,6(1H,5H)dione derivatives have been synthesized from isatoic anhydride and 3-(R(2)-amino)-1,4,2-benzodithiazine 1,1-dioxides. Some synthetic limitations are discussed on the basis of quantum chemical calculations performed by use of the Hartree-Fock method.

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Mentions: Previously described methods were used for synthesis of 3-amino-6-chloro-1,4,2-benzodithiazine derivatives 1a-1e [3], 1f, 1g [27], 1h [39], 1l–1p [9], 1r [40], 1s, and 1t [41]. Similar methods were used to prepare the new starting benzodithiazines 1i, 1j, and 1k (Scheme 1).


Synthesis of a new series of biologically interesting 6'-chloro-1',1'-dioxospiro[4H-benzo[d][1,3,7]oxadiazocine-4,3'(2'H)-[1,4,2]benzodithiazine]-2,6(1H,5H)dione derivatives.

Brzozowski Z, Żołnowska B, Sławiński J - Monatsh. Chem. (2013)

·
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4495064&req=5

Sch1: ·
Mentions: Previously described methods were used for synthesis of 3-amino-6-chloro-1,4,2-benzodithiazine derivatives 1a-1e [3], 1f, 1g [27], 1h [39], 1l–1p [9], 1r [40], 1s, and 1t [41]. Similar methods were used to prepare the new starting benzodithiazines 1i, 1j, and 1k (Scheme 1).

Bottom Line: A series of 6'-chloro-1',1'-dioxospiro[4H-benzo[d][1,3,7]oxadiazocine-4,3'(2'H)-[1,4,2]benzodithiazine]-2,6(1H,5H)dione derivatives have been synthesized from isatoic anhydride and 3-(R(2)-amino)-1,4,2-benzodithiazine 1,1-dioxides.Some synthetic limitations are discussed on the basis of quantum chemical calculations performed by use of the Hartree-Fock method.

View Article: PubMed Central - PubMed

Affiliation: Department of Organic Chemistry, Medical University of Gdańsk, Gen. J. Hallera Str. 107, 80416 Gdańsk, Poland.

ABSTRACT

Abstract: A series of 6'-chloro-1',1'-dioxospiro[4H-benzo[d][1,3,7]oxadiazocine-4,3'(2'H)-[1,4,2]benzodithiazine]-2,6(1H,5H)dione derivatives have been synthesized from isatoic anhydride and 3-(R(2)-amino)-1,4,2-benzodithiazine 1,1-dioxides. Some synthetic limitations are discussed on the basis of quantum chemical calculations performed by use of the Hartree-Fock method.

No MeSH data available.