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Insight into the Spectrum of Coronary Atherosclerosis in Asymptomatic Urban Han Chinese Population by Coronary Computed Tomography Angiography.

Li J, Liu R, Ji X, Xue H, Zhang G, Wang C, Chen Q, Xue F, Cui L - PLoS ONE (2015)

Bottom Line: The most lesion segment emerged on proximal LAD, followed by proximal RCA, mid LAD, proximal LCX, and mid RCA with mixed plaque as dominant.The atherosclerosis plaque burden was about one in ten as high-risk individuals in this specific urban Han Chinese population.As potential surrogation of CTA, HDL-C was recognized as a significant predictor to atherosclerosis burden and revealed a good performance for identifying high-risk individuals.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China.

ABSTRACT

Objectives: Highlighted the spectrum of coronary atherosclerosis in asymptomatic population by Computed Tomography Angiography (CTA) and developed a surrogation of expensive CTA to early detect coronary atherosclerosis.

Methods: Three hundred and seven self-referred urban Han Chinese asymptomatic individuals underwent coronary CTA were consecutively enrolled. Total plaque score (TPS), Segment stenosis score (SSS) and Coronary Artery Disease severity (CADS) were used to measure and illustrate the spectrum of atherosclerosis burden by mapping their incidence and proportion onto coronary artery tree. Logistic regression model was further used to explore the association between lipid biomarkers and TPS (SSS) for developing a surrogation of CTA to early detect coronary atherosclerosis.

Results: We found that the incidence of TPS, SSS and CADS were up to 71.34%, 68.08%, and 71.34%; and high-risk individuals reached up to 11.07%, 15.31% and 16.29% respectively. All TPS, SSS and CADS were much higher in male than female, and have trend of increasing with age. The most lesion segment emerged on proximal LAD, followed by proximal RCA, mid LAD, proximal LCX, and mid RCA with mixed plaque as dominant. HDL-C was a predictor to both TPS [OR: 0.12 (0.02-0.82)] and SSS [OR: 0.15 (0.03-0.76)], and could identify the serious atherosclerosis subjects of TPS or SSS score >5 (AUC 0.73 and 0.70).

Conclusions: The atherosclerosis plaque burden was about one in ten as high-risk individuals in this specific urban Han Chinese population. As potential surrogation of CTA, HDL-C was recognized as a significant predictor to atherosclerosis burden and revealed a good performance for identifying high-risk individuals.

No MeSH data available.


Related in: MedlinePlus

The frequency distribution of TPS and SSS score.TPS and SSS score were left skewness distribution. SSS = segment-stenosis score. TPS = total plaque score.
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pone.0132188.g001: The frequency distribution of TPS and SSS score.TPS and SSS score were left skewness distribution. SSS = segment-stenosis score. TPS = total plaque score.

Mentions: Fig 1 showed the general frequency distribution of TPS and SSS score, suggesting that both of them were extreme skewness distribution with their right long tail (S1 Data). For TPS (Table 2 and S1 Data), the median score was 2 with IQR of 3.5 for male and 1 with IQR of 2 for female (corresponding their mean score with deviation of 2.42±2.58 for male and 1.55±2.00 for female). The incidence of atherosclerosis plaque (score ≥1) was up to 71.34% (219/307) but just 11.07% (34/307) for score >5, indicating that the atherosclerosis plaque burden was serious with about one tenth as high risk individuals in this specific urban Han Chinese population. Similar trend (Table 2 and S1 Data) was also observed for SSS (median±IQR:2±3 for male and 1±2 for female, corresponding mean±deviation of 2.53±3.11 for male and 1.82±2.98 for female), with the incidence of 68.08% (209/307) for score ≥1, and of 15.31% (47/307) for score >5. For CADS (Table 2), incidence of stenosis was up to 71.34% (219/307), while obstructive CAD (any coronary lumen lesions >50%) reached 16.29% (50/307).


Insight into the Spectrum of Coronary Atherosclerosis in Asymptomatic Urban Han Chinese Population by Coronary Computed Tomography Angiography.

Li J, Liu R, Ji X, Xue H, Zhang G, Wang C, Chen Q, Xue F, Cui L - PLoS ONE (2015)

The frequency distribution of TPS and SSS score.TPS and SSS score were left skewness distribution. SSS = segment-stenosis score. TPS = total plaque score.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4495057&req=5

pone.0132188.g001: The frequency distribution of TPS and SSS score.TPS and SSS score were left skewness distribution. SSS = segment-stenosis score. TPS = total plaque score.
Mentions: Fig 1 showed the general frequency distribution of TPS and SSS score, suggesting that both of them were extreme skewness distribution with their right long tail (S1 Data). For TPS (Table 2 and S1 Data), the median score was 2 with IQR of 3.5 for male and 1 with IQR of 2 for female (corresponding their mean score with deviation of 2.42±2.58 for male and 1.55±2.00 for female). The incidence of atherosclerosis plaque (score ≥1) was up to 71.34% (219/307) but just 11.07% (34/307) for score >5, indicating that the atherosclerosis plaque burden was serious with about one tenth as high risk individuals in this specific urban Han Chinese population. Similar trend (Table 2 and S1 Data) was also observed for SSS (median±IQR:2±3 for male and 1±2 for female, corresponding mean±deviation of 2.53±3.11 for male and 1.82±2.98 for female), with the incidence of 68.08% (209/307) for score ≥1, and of 15.31% (47/307) for score >5. For CADS (Table 2), incidence of stenosis was up to 71.34% (219/307), while obstructive CAD (any coronary lumen lesions >50%) reached 16.29% (50/307).

Bottom Line: The most lesion segment emerged on proximal LAD, followed by proximal RCA, mid LAD, proximal LCX, and mid RCA with mixed plaque as dominant.The atherosclerosis plaque burden was about one in ten as high-risk individuals in this specific urban Han Chinese population.As potential surrogation of CTA, HDL-C was recognized as a significant predictor to atherosclerosis burden and revealed a good performance for identifying high-risk individuals.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China.

ABSTRACT

Objectives: Highlighted the spectrum of coronary atherosclerosis in asymptomatic population by Computed Tomography Angiography (CTA) and developed a surrogation of expensive CTA to early detect coronary atherosclerosis.

Methods: Three hundred and seven self-referred urban Han Chinese asymptomatic individuals underwent coronary CTA were consecutively enrolled. Total plaque score (TPS), Segment stenosis score (SSS) and Coronary Artery Disease severity (CADS) were used to measure and illustrate the spectrum of atherosclerosis burden by mapping their incidence and proportion onto coronary artery tree. Logistic regression model was further used to explore the association between lipid biomarkers and TPS (SSS) for developing a surrogation of CTA to early detect coronary atherosclerosis.

Results: We found that the incidence of TPS, SSS and CADS were up to 71.34%, 68.08%, and 71.34%; and high-risk individuals reached up to 11.07%, 15.31% and 16.29% respectively. All TPS, SSS and CADS were much higher in male than female, and have trend of increasing with age. The most lesion segment emerged on proximal LAD, followed by proximal RCA, mid LAD, proximal LCX, and mid RCA with mixed plaque as dominant. HDL-C was a predictor to both TPS [OR: 0.12 (0.02-0.82)] and SSS [OR: 0.15 (0.03-0.76)], and could identify the serious atherosclerosis subjects of TPS or SSS score >5 (AUC 0.73 and 0.70).

Conclusions: The atherosclerosis plaque burden was about one in ten as high-risk individuals in this specific urban Han Chinese population. As potential surrogation of CTA, HDL-C was recognized as a significant predictor to atherosclerosis burden and revealed a good performance for identifying high-risk individuals.

No MeSH data available.


Related in: MedlinePlus